BSA-coated β-FeOOH nanoparticles efficiently deliver the photosensitizer chlorin e6 for synergistic anticancer PDT/CDT

Hu, Han; Li, Ruiqi; Huang, Pinbo; Mo, Zhimin; Xu, Qi; Hu, Tao; Yao, Shijie; Dai, Xin; Xu, Zushun

doi:10.1016/j.colsurfb.2022.113117

Cited by 8 publications

(4 citation statements)

References 50 publications

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“…Although CDT has provided a new direction for treating tumors, the CDT alone is not sufficient to tackle tumor growth and inhibit tumor metastasis in most cases. In order to improve the cancer treatment efficacy, CDT has been combined with different therapeutic modalities such as PTT, [ 35 ] PDT, [ 36 ] and chemotherapy. [ 37 ] Some combinations have even demonstrated excellent “1 + 1 > 2” therapeutic effect as reported by Wu et al [ 38 ] The highly branched structure, unique internal cavity, and abundant periphery functional groups of dendrimers make them very suitable for carrying various therapeutic agents for combined tumor treatment.…”

Section: Pamam Dendrimer‐based Nanodrugs For Cdt and Combination Ther...mentioning

confidence: 99%

Dendrimer‐Based Nanodrugs for Chemodynamic Therapy of Tumors

Zhang,

Guo,

Shen

et al. 2024

Advanced NanoBiomed Research

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To realize precise tumor treatment, chemodynamic therapy (CDT) that utilizes metal element to trigger Fenton or Fenton‐like reaction to generate cytotoxic hydroxyl radicals in tumor region has been widely investigated. Recently, the dendrimers featured with abundant surface functional groups and excellent biocompatibility are regarded as promising carriers of metal elements for tumor delivery. Much effort has been devoted to design dendrimer‐based nanodrugs for CDT and CDT‐involved synergistic therapy of tumors. Herein, the recent advances in the construction of dendrimer‐based nanodrugs (in most cases, poly(amidoamine) dendrimers) for CDT, CDT/chemotherapy, CDT/phototherapy, CDT/gene therapy, or CDT‐involved multimodal therapy are reviewed. Furthermore, the future perspectives with regard to the development of dendrimer‐based nanodrugs for CDT‐involved tumor treatment are also briefly discussed.

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Section: Pamam Dendrimer‐based Nanodrugs For Cdt and Combination Ther...mentioning

confidence: 99%

Dendrimer‐Based Nanodrugs for Chemodynamic Therapy of Tumors

Zhang,

Guo,

Shen

et al. 2024

Advanced NanoBiomed Research

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“…Therefore, PDT could be an enhancer for ROS generation, complementing chemodynamic therapy (CDT). 22,23 The therapeutic mechanisms of both CDT and PDT are based on ROS production. In CDT, the unstable ROS ( • OH, O 2…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, PDT provides an opportunity to selectively induce programmed cell death by precisely targeting specific sites for irradiation. Therefore, PDT could be an enhancer for ROS generation, complementing chemodynamic therapy (CDT). , The therapeutic mechanisms of both CDT and PDT are based on ROS production. In CDT, the unstable ROS ( • OH, O 2 •– ) are typically produced by the redox system involving oxiGSH or reducible metal ions, depleting H 2 O 2 in the presence of oxygen. − This process is called Fenton-type chemistry, and it depends on the H 2 O 2 level in the target area .…”

Section: Introductionmentioning

confidence: 99%

In Situ Activatable Nitrobenzene–Cysteine–Copper(II) Nano-complexes for Programmed Photodynamic Cancer Therapy

Kang,

Jeong,

Jeong

et al. 2023

J. Am. Chem. Soc.

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“…For example, Hu et al synthesized Ce6/FeOOH@BSA for PDT and CDT treatment with Ce6 as the photosensitizer and FeOOH as the catalyst. [21] The combination of materials with individual functions requires a complex synthesis process and abundant operational steps. Therefore, it is challenging to prepare nanostructures for two therapeutic modalities and real-time MR imaging ability in one step.…”

Section: Introductionmentioning

confidence: 99%

Manganese Amplifies Photoinduced ROS in Toluidine Blue Carbon Dots to Boost MRI Guided Chemo/Photodynamic Therapy

Chu,

Qu,

Huang

et al. 2023

Small

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The contrast agents and tumor treatments currently used in clinical practice are far from satisfactory, due to the specificity of the tumor microenvironment (TME). Identification of diagnostic and therapeutic reagents with strong contrast and therapeutic effect remains a great challenge. Herein, a novel carbon dot nanozyme (Mn‐CD) is synthesized for the first time using toluidine blue (TB) and manganese as raw materials. As expected, the enhanced magnetic resonance (MR) imaging capability of Mn‐CDs is realized in response to the TME (acidity and glutathione), and r1 and r2 relaxation rates are enhanced by 224% and 249%, respectively. In addition, the photostability of Mn‐CDs is also improved, and show an efficient singlet oxygen (1O2) yield of 1.68. Moreover, Mn‐CDs can also perform high‐efficiency peroxidase (POD)‐like activity and catalyze hydrogen peroxide to hydroxyl radicals, which is greatly improved under the light condition. The results both in vitro and in vivo demonstrate that the Mn‐CDs are able to achieve real‐time MR imaging of TME responsiveness through aggregation of the enhanced permeability and retention effect at tumor sites and facilitate light‐enhanced chemodynamic and photodynamic combination therapies. This work opens a new perspective in terms of the role of carbon nanomaterials in integrated diagnosis and treatment of diseases.

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BSA-coated β-FeOOH nanoparticles efficiently deliver the photosensitizer chlorin e6 for synergistic anticancer PDT/CDT

Cited by 8 publications

References 50 publications

Dendrimer‐Based Nanodrugs for Chemodynamic Therapy of Tumors

Dendrimer‐Based Nanodrugs for Chemodynamic Therapy of Tumors

In Situ Activatable Nitrobenzene–Cysteine–Copper(II) Nano-complexes for Programmed Photodynamic Cancer Therapy

Manganese Amplifies Photoinduced ROS in Toluidine Blue Carbon Dots to Boost MRI Guided Chemo/Photodynamic Therapy

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