An Open Label Parallel Group Study to Assess the Effects of Amlodipine and Cilnidipine on Pulse Wave Velocity and Augmentation Pressures in Mild to Moderate Essential Hypertensive Patients

Pathapati, Rama Mohan; Rajashekar, Sujith Tumkur; Buchineni, Madhavulu; Meriga, Rajesh Kumar; Reddy, Chirra Bhakthavasthala; Kumar, K. Praveen

doi:10.7860/jcdr/2015/12702.6754

Cited by 5 publications

(3 citation statements)

References 25 publications

(15 reference statements)

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“…It was reported that 8 wk of antihypertensive therapy with amlodipine decreased arterial stiffness in mild to moderate hypertensive patients, but the reduction was smaller than other calcium channel blockers (30). Although we added amlodipine to aliskiren and hydrochlorothiazide to eliminate the difference in blood pressure reduction influence on arterial stiffness, the number of patients taking amlodipine was very small and similar between groups, and moreover, the dose used did not differ between groups.…”

Section: Arterial Stiffnessmentioning

confidence: 88%

Long-term effects of a renin inhibitor versus a thiazide diuretic on arterial stiffness and left ventricular diastolic function in elderly hypertensive patients

Okada

Shibata

Fujimoto

et al. 2017

American Journal of Physiology-Regulatory, Integrative and Comp

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Arterial stiffness and cardiac function are important predictors of cardiovascular events in patients with hypertension, even with adequate blood pressure (BP) control. We evaluated whether a direct renin inhibitor, aliskiren, reduces arterial stiffness and modulates left ventricular function compared with a diuretic, hydrochlorothiazide, in elderly hypertensive patients. Twenty-one hypertensive patients [67 ± 14 (SD) yr] were randomly assigned to receive 6-mo aliskiren ( = 11) or hydrochlorothiazide ( = 10)-based therapy. We assessed β-stiffness of the local arteries, arterial elastance (), and echocardiographic variables, including early () and late () mitral inflow velocity, deceleration time of E, early (') and late (') diastolic mitral annular velocity, and left ventricular end-systolic elastance () before and after treatment. BP decreased similarly ( < 0.001) after both therapies. β-Stiffness of the carotid artery decreased after aliskiren but increased after hydrochlorothiazide treatment (aliskiren: 6.42 ± 2.34 pre vs. 5.07 ± 1.29 post; hydrochlorothiazide: 5.05 ± 1.78 vs. 7.25 ± 2.68, = 0.001 for interaction). β-Stiffness of the femoral and radial arteries were not different after either treatment. Different from aliskiren, decreased (73 ± 16 vs. 67 ± 14 cm/s, = 0.026), and the deceleration time was prolonged (218 ± 40 vs. 236 ± 35 ms, = 0.032) after hydrochlorothiazide therapy, whereas the /, and ' remained unchanged after both treatments. and decreased after aliskiren therapy (both < 0.05), whereas the / (ventricular-arterial coupling) was maintained after both treatments. Thus, aliskiren decreased the stiffness of carotid artery and left ventricular end-systolic elastance with maintenance of ventricular-arterial coupling without any effects on diastolic filling, while hydrochlorothiazide increased carotid arterial stiffness and slowed early diastolic filling in elderly hypertensive patients.

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Section: Arterial Stiffnessmentioning

confidence: 88%

Long-term effects of a renin inhibitor versus a thiazide diuretic on arterial stiffness and left ventricular diastolic function in elderly hypertensive patients

Okada

Shibata

Fujimoto

et al. 2017

American Journal of Physiology-Regulatory, Integrative and Comp

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“… Minami et al [ 17 ]; Sakata et al [ 18 ]; Takeda et al [ 19 ]; Rose et al [ 20 ]; Kojima et al [ 21 ]; Tsuchihashi et al [ 22 ]; Morimoto et al [ 23 ]; Fujita et al [ 24 ]; Hong et al [ 25 ]; Konoshita et al [ 26 ]; Abe et al [ 27 ]; Miwa et al [ 28 ]; Abe et al [ 29 ]; Kanoaka et al [ 30 ]; Adake et al [ 11 ]; Singh et al [ 31 ]; Pathapati et al [ 32 ]; Masaki et al [ 33 ]; Das et al [ 34 ]; Singal et al [ 35 ]; Hwang et al [ 36 ]; Oh et al [ 37 ]; Kawabata et al [ 38 ]; Fujiwara et al [ 39 ] …”

Section: Reviewmentioning

confidence: 99%

“…FIGURE 2: Forest plot for change in SBP (K=24) SBP: systolic blood pressure; REML: random-effects model; SD: standard deviation; CI: confidence intervals Minami et al [17]; Sakata et al [18]; Takeda et al [19]; Rose et al [20]; Kojima et al [21]; Tsuchihashi et al [22]; Morimoto et al [23]; Fujita et al [24]; Hong et al [25]; Konoshita et al [26]; Abe et al [27]; Miwa et al [28]; Abe et al[29]; Kanoaka et al[30]; Adake et al[11]; Singh et al[31]; Pathapati et al[32]; Masaki et al[33]; Das et al[34]; Singal et al[35]; Hwang et al[36]; Oh et al[37]; Kawabata et al[38]; Fujiwara et al[39] …”

mentioning

confidence: 99%

Efficacy of Cilnidipine (L/N-type Calcium Channel Blocker) in Treatment of Hypertension: A Meta-Analysis of Randomized and Non-randomized Controlled Trials

Chakraborty¹,

Langade²,

More³

et al. 2021

Cureus

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Introduction: Hypertension is one of the most common cardiovascular diseases, and the prevalence of hypertension continues to rise across the globe. National and international guidelines recommend angiotensin-converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARBs), calcium channel blockers (CCBs), diuretics, and beta-blockers for the management of hypertension. CCBs are among the most used antihypertensive medications and Cilnidipine is a newer dihydropyridine CCB shown to have a prolonged antihypertensive property. Objective: This meta-analysis of comparative randomized and non-randomized clinical trials evaluated the effect of Cilnidipine monotherapy or combination therapy on systolic blood pressure (SBP), diastolic blood pressure (DBP), and pulse rate (PR) over 48 weeks of therapy. Study design: PubMed (MEDLINE) and Google scholar databases were searched to identify studies designed to evaluate the effects of Cilnidipine in the treatment of hypertensive patients. The study criteria for inclusion into the meta-analysis were all prospective, randomized, and non-randomized clinical studies published till March 2021, studies published in a peer-reviewed journal, the inclusion of patients with hypertension, assessment of blood pressure and heart rate, and a follow-up of four weeks or longer. The initial search identified 82 potential articles; of these, 24 met the inclusion criteria. Studies with <4 weeks treatment period and those not having a CCB were excluded. Outcomes: Change in SBP, DBP, and PR from baseline at the end of therapy compared between the Cilnidipine and other CCB's. Results: Cilnidipine caused a significant reduction (p<0.05) in SBP, DBP, and PR at end of therapy, whereas the reduction in SBP, DBP, and PR with Cilnidipine was similar to other CCB's (p>0.05). The results of this meta-analysis revealed that there were no significant differences in the efficacy in the treatment of hypertensive patients with Cilnidipine and the other therapies. Conclusion: Cilnidipine has similar anti-hypertensive effects compared with other first-line antihypertensive drugs commonly used in practice. We recommend Cilnidipine as a novel first-line CCB for the management of hypertension either as a monotherapy or as a combination therapy.

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Differential impact of antihypertensive drugs on cardiovascular remodeling: a review of findings and perspectives for HFpEF prevention

Takami¹,

Hoshide

Kario

2021

Hypertens Res

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An Open Label Parallel Group Study to Assess the Effects of Amlodipine and Cilnidipine on Pulse Wave Velocity and Augmentation Pressures in Mild to Moderate Essential Hypertensive Patients

Cited by 5 publications

References 25 publications

Long-term effects of a renin inhibitor versus a thiazide diuretic on arterial stiffness and left ventricular diastolic function in elderly hypertensive patients

Long-term effects of a renin inhibitor versus a thiazide diuretic on arterial stiffness and left ventricular diastolic function in elderly hypertensive patients

Efficacy of Cilnidipine (L/N-type Calcium Channel Blocker) in Treatment of Hypertension: A Meta-Analysis of Randomized and Non-randomized Controlled Trials

Differential impact of antihypertensive drugs on cardiovascular remodeling: a review of findings and perspectives for HFpEF prevention

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