2006
DOI: 10.1001/archderm.142.12.1568
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An Open-label Adrenal Suppression Study of 0.1% Fluocinonide Cream in Pediatric Patients With Atopic Dermatitis

Abstract: To assess the potential of a superhighpotency 0.1% fluocinonide cream to suppress the hypothalamic-pituitary-adrenal (HPA) axis in pediatric patients with atopic dermatitis.Design: A multicenter, multiple-dose, open-label safety study in 4 age cohorts with 0.1% fluocinonide cream applied once or twice daily for 2 weeks.Setting: Clinical outpatient setting.Patients: Patients with moderate to severe atopic dermatitis with 20% or more of the body surface area involved were included in the study. Each cohort began… Show more

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Cited by 32 publications
(21 citation statements)
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“…A total of 12 trials [112][113][114][115][116][117][118][119][120][121][122] were reported from 2000 onwards, with two trials reported together in one report. 113 Ten of these trials compared novel topical corticosteroids with standard topical corticosteroids and one trial 118 compared a topical corticosteroid with and without the addition of a penetration-enhancing drug.…”
Section: Studiesmentioning
confidence: 99%
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“…A total of 12 trials [112][113][114][115][116][117][118][119][120][121][122] were reported from 2000 onwards, with two trials reported together in one report. 113 Ten of these trials compared novel topical corticosteroids with standard topical corticosteroids and one trial 118 compared a topical corticosteroid with and without the addition of a penetration-enhancing drug.…”
Section: Studiesmentioning
confidence: 99%
“…This trial report was very short and there were very few details provided about the trial. Nine of these trials [112][113][114][115][116][117]122 compared treatments exclusively in children and three trials [118][119][120] did not report the age of the participants. Six of the trials 113,[116][117][118]121 had > 100 participants and six 112,114,115,119,120,122 had ≤ 50 participants.…”
Section: Studiesmentioning
confidence: 99%
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“…In a separate study of two-week fluocinonide 0.1% cream treatment in pediatric subjects with atopic dermatitis, there was no evidence of HPA axis suppression on CST testing in any subject with QD application, even in children <2 years of age. 22 In addition to lower drug exposure, once-daily application may improve adherence and enhance therapeutic efficacy in patients of all ages. A meta-analysis of 11 studies of patients with skin disorders found that mean adherence to the prescribed treatment was 77 percent.…”
Section: Discussionmentioning
confidence: 99%