Suppression of the HPA Axis in Pediatric Patients With Atopic Dermatitis

Ishay, Avraham

doi:10.1001/archderm.143.11.1449-b

Cited by 4 publications

(3 citation statements)

References 5 publications

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“…12–14 Chronic stress has also been found to be associated with impairment of HPA response and low cortisol levels. 15 Chronic stress in atopic dermatitis, of which pruritus is a major factor, can perpetuate the neuroendocrine dysfunction initiated by allergic inflammation and lead to aggravation of disease, forming a vicious cycle.…”

Section: Psychophysiology Of Pruritusmentioning

confidence: 99%

Psychosomatic factors in pruritus

Tey

Wallengren

Yosipovitch

2013

Clinics in Dermatology

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Pruritus and psyche are intricately and reciprocally related, with psychophysiological evidence and psychopathological explanations helping us to understand their complex association. Their interaction may be conceptualized and classified into 3 groups: pruritic diseases with psychiatric sequelae, pruritic diseases aggravated by psychosocial factors, and psychiatric disorders causing pruritus. Management of chronic pruritus is directed at treating the underlying causes and adopting a multidisciplinary approach to address the dermatologic, somatosensory, cognitive, and emotional aspects. Pharmcotherapeutic agents that are useful for chronic pruritus with comorbid depression and/or anxiety comprise selective serotonin reuptake inhibitors, mirtazapine, tricyclic antidepressants (amitriptyline and doxepin), and anticonvulsants (gabapentin, pregabalin); the role of neurokinin receptor-1 antagonists awaits verification. Antipsychotics are required for treating itch and formication associated with schizophrenia and delusion of parasitosis (including Morgellons disease).

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Section: Psychophysiology Of Pruritusmentioning

confidence: 99%

Psychosomatic factors in pruritus

Tey

Wallengren

Yosipovitch

2013

Clinics in Dermatology

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“… 30 ; Ishay et al. 31 ). There is also a need to examine the manner in which sensory hypersensitivity is expressed in daily living situations.…”

Section: Discussionmentioning

confidence: 99%

“…However, previous studies of sensory sensitivity used mainly neurophysiological tools (e.g. Seike et al 30 ; Ishay et al 31 ). There is also a need to examine the manner in which sensory hypersensitivity is expressed in daily living situations.…”

Section: Discussionmentioning

confidence: 99%

Sensory processing patterns of adults with atopic dermatitis

Engel‐Yeger

Mimouni

Rozenman

et al. 2011

Acad Dermatol Venereol

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Predictors and Correlates of Pediatric Postburn Pruritus in Preschool Children of Ages 0 to 4

Stewart

Caradec

Ziegfeld

et al. 2019

Journal of Burn Care &Amp; Research

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Pruritus is a common problem following burn injuries; however, the literature to date has focused on adult survivors and/or pediatric survivors of large burns. The current study examines acute postburn pruritus in children under the age of 4 years (N = 256) with smaller burns (mean TBSA = 3.99%), which represents the most common type of patient typically treated in pediatric burn centers. Parents rated their child for pruritus, irritability, and sleep disturbances; additionally, parents completed a self-report of distress. Nearly half (47.3%) were rated by parents as displayed some level of pruritus, with the greatest proportion rated as mild. Regression analysis indicated that child minority status, greater burn TBSA, and more days elapsed since burn predicted higher levels of pruritus. In turn, pruritus was positively correlated with child irritability, delayed sleep onset, sleep disturbance, and parent distress. Thus, our results indicate that parent-rated pruritus in young pediatric burn patients is important to evaluate, as itch is significantly associated with other important clinical outcomes as early as the first month of the burn for pediatric patients and their parents.

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Suppression of the HPA Axis in Pediatric Patients With Atopic Dermatitis

Cited by 4 publications

References 5 publications

Psychosomatic factors in pruritus

Psychosomatic factors in pruritus

Sensory processing patterns of adults with atopic dermatitis

Predictors and Correlates of Pediatric Postburn Pruritus in Preschool Children of Ages 0 to 4

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