An on–off biosensor based on multistimuli-responsive polymer films with a binary architecture and bioelectrocatalysis

Zhang, Kaina; Liang, Yan; Liú, Dan; Liu, Hongyun

doi:10.1016/j.snb.2012.07.016

Cited by 26 publications

(21 citation statements)

References 46 publications

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“…Moreover, most of the available potentiometric sensors are essentially based on poorly resolved signals of polymers such as polypyrrole, polyaniline and poly(4-vinylpyridine) used for the detection of environmental and biological analytes. [17][18][19] In this work the design of a new kind of potentiometric-responsive immunosensor formed by anti-human IgG (aHIgG Ab) conjugated to FcD/AuNP aggregates with a well-dened signal of ferrocene is reported. The FcD/AuNP aggregations acted as a sensitive peak potential shiing transducer.…”

Section: Introductionmentioning

confidence: 99%

Gold nanoparticles decorated with a ferrocene derivative as a potential shift-based transducing system of interest for sensitive immunosensing

Mars

Parolo²,

Raouafi

et al. 2013

J. Mater. Chem. B

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Section: Introductionmentioning

confidence: 99%

Gold nanoparticles decorated with a ferrocene derivative as a potential shift-based transducing system of interest for sensitive immunosensing

Mars

Parolo²,

Raouafi

et al. 2013

J. Mater. Chem. B

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“…It should be noticed that the ΔpH between the ON and OFF states for this system was only 1.2 pH units (Figures 4 and S6 of the Supporting Information), much less than that reported in the literature. 10,[16][17][18][19]36 The CV response of Fc(COOH) 2 at P(DEA-co-MAA)-GOD film electrodes was also sensitive to the concentration of CO 2 in the testing solution. After CO 2 was bubbled for 10 min in pH 7.4 buffers at 37 °C, the CV peak currents of the probe decreased remarkably in comparison with the original ones, and the films were at the OFF state (Figure 5, curves a and b).…”

Section: ■ Resultsmentioning

confidence: 99%

“…This should be attributed to the thermosensitive property of the PDEA component in the films instead of the PMAA constituent, since no temperatureresponsive behavior was observed for PMAA polymers. 39 Moreover, the CVs of Fc(COOH) 2 at bare PG electrodes showed no temperature-dependent property, 17,18 indicating that the probe itself is not thermosensitive.…”

Section: ■ Discussionmentioning

confidence: 99%

Multiple Stimuli-Switchable Bioelectrocatalysis under Physiological Conditions Based on Copolymer Films with Entrapped Enzyme

Wang

Liu

2014

J. Phys. Chem. B

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In the present work, N,N-diethylacrylamide (DEA) and methyl acrylic acid (MAA) monomers were copolymerized into P(DEA-co-MAA) thin films on the electrode surface with a simple one-step polymerization method at ambient temperature and pressure, and the enzyme glucose oxidase (GOD) was entrapped in the films, designed as P(DEA-co-MAA)-GOD. The cyclic voltammetric (CV) response of ferrocene dicarboxylic acid (Fc(COOH)2) at the film electrodes was very sensitive to environmental stimuli, such as temperature, pH, the identity and concentration of anions, and the concentration of CO2 in solution. This multiresponsive CV behavior of the system could be further employed to switch the electrochemical oxidation of glucose catalyzed by GOD entrapped in the films with Fc(COOH)2 as the mediator in solution, demonstrating the amplification effect. The SEM and stereomicroscopy results showed that the multisensitive behaviors of the system were attributed to the structure change of the copolymer films with the stimuli. Specifically, the synergistic effect of temperature and pH was observed, and the hydrogen bonding between PDEA and PMAA components in the copolymer played a key role for this. The present system could be performed under physiological conditions at 37 °C and pH 7.4, which may offer numerous possibilities not only to design new multiswitchable biosensors based on bioelectrocatalysis but also to establish foundations for controlled drug delivery and other medical applications.

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“…It was found that reversibly switchable electrochemical reduction of H 2 O 2 catalyzed by HRP could be simultaneously triggered and modulated by pH, temperature, and sulfate concentration in solution 233. Liu et al designed multi‐stimuli‐responsive films with the binary architecture composed of poly(4‐vinylpyridine) as the inner layers and poly( N , N ′ ‐ diethylacrylamide) hydrogels containing GOD as the outer layers on the electrode surface, which exhibited reversible pH, thermo‐,

{ClO}_{4}^{-}

‐, and

{SO}_{4}^{2 -}

‐responsive CV on/off behavior toward ferrocenedicarboxylic acid (Fc(COOH) 2 ) 234. The group also developed multi‐stimuli‐responsive P(DEA‐ co ‐MAA) thin films on the electrode surface with a simple one‐step polymerization method at ambient temperature and pressure.…”

Section: Multi‐stimuli‐responsive Filmsmentioning

confidence: 99%

Multi-Stimuli-Responsive Polymer Materials: Particles, Films, and Bulk Gels

Cao

Wang

2016

The Chemical Record

171

109

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Stimuli-responsive polymers have received tremendous attention from scientists and engineers for several decades due to the wide applications of these smart materials in biotechnology and nanotechnology. Driven by the complex functions of living systems, multi-stimuli-responsive polymer materials have been designed and developed in recent years. Compared with conventional single- or dual-stimuli-based polymer materials, multi-stimuli-responsive polymer materials would be more intriguing since more functions and finer modulations can be achieved through more parameters. This critical review highlights the recent advances in this area and focuses on three types of multi-stimuli-responsive polymer materials, namely, multi-stimuli-responsive particles (micelles, micro/nanogels, vesicles, and hybrid particles), multi-stimuli-responsive films (polymer brushes, layer-by-layer polymer films, and porous membranes), and multi-stimuli-responsive bulk gels (hydrogels, organogels, and metallogels) from recent publications. Various stimuli, such as light, temperature, pH, reduction/oxidation, enzymes, ions, glucose, ultrasound, magnetic fields, mechanical stress, solvent, voltage, and electrochemistry, have been combined to switch the functions of polymers. The polymer design, preparation, and function of multi-stimuli-responsive particles, films, and bulk gels are comprehensively discussed here.

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An on–off biosensor based on multistimuli-responsive polymer films with a binary architecture and bioelectrocatalysis

Cited by 26 publications

References 46 publications

Gold nanoparticles decorated with a ferrocene derivative as a potential shift-based transducing system of interest for sensitive immunosensing

Gold nanoparticles decorated with a ferrocene derivative as a potential shift-based transducing system of interest for sensitive immunosensing

Multiple Stimuli-Switchable Bioelectrocatalysis under Physiological Conditions Based on Copolymer Films with Entrapped Enzyme

Multi-Stimuli-Responsive Polymer Materials: Particles, Films, and Bulk Gels

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