An oleuropein rich-olive (Olea europaea L.) leaf extract reduces β-amyloid and tau proteotoxicity through regulation of oxidative- and heat shock-stress responses in Caenorhabditis elegans

The endophytic fungus Penicillium oxalicum isolated from Ligusticum chuanxiong Hort possesses DNA damage-protecting potential and increases stress resistance properties in Caenorhabditis elegans

“…Thus, the enhanced antistress ability of worms treated with POE found in the present study is not in line with lifespan extension, consistent with the observations of Duangjan et al (2021) working. Moreover, lifespan analysis was used to evaluate the long-term toxicity of extracts ( Romero-Márquez et al, 2022 ). Thus, the results also showed that POE has no long-term toxicity to worms.…”

Amyloid β-but not Tau-induced neurotoxicity is suppressed by Manuka honeyviaHSP-16.2 and SKN-1/Nrf2 pathways in anin vivomodel of Alzheimer's disease

“…It would be interesting, for future research, to assess whether MH, in addition to reducing the aggregation of the Aβ peptide, is capable of reducing Aβ oligomers, since it is well known that they are more toxic than Aβ monomers and have been related to memory loss and severity of dementia 13,52 Aβ oligomers may damage neurons by interfering with neuron-to-neuron communication at synapses. 5 Many other natural compounds, such as betaine, 49 Ginkgo biloba extract, 7 gennianchun, 7 Sideritis scardica extracts, 53 fucoidan, 54 ergothioneine, 55 frondoside A, 56 spermidine, 57 essential Oil of Acorus tatarinowii Schott, 58 allophycocyanin, 50 caffeic acid, 4 strawberry extract, 15 carnosic acid, 3 scutellarein, 59 oleuropein, 17 hydroxytyrosol, 16,59 and red-beet betalain pigments, 60 also protect C. elegans nematodes against Aβ-induced toxicity.…”

“…7,62–64 Moreover, the response against oxidative stress is also mediated by the joint action of other factors such as SKN-1, SMK-1 (a regulatory subunit of the PP4 protein phosphatase complex) and HSF-1. 62 Up to the present, it has been reported that several compounds extend lifespan and reduce Aβ-induced toxicity in C. elegans via DAF-16, as for example royal jelly, 65 monascin, 66 dianxianning, 52 gengnianchun, 7 phosphatidylcholine, 64 Zijuan Pu'er tea extract, 67 Hibiscus sabdariffa L. extract, 68 strawberry extract, 15 oleuropein, 17 Moringa oleífera extract, 69 and hydroxytyrosol. 16 However, under our experimental conditions, DAF-16 and SOD-3 RNAi failed to delay the Aβ-induced paralysis, indicating that MH attenuation of neurotoxicity is not mediated by these pathways.…”

“…TAC of MH was evaluated by ferric reducing antioxidant power (FRAP), trolox equivalent antioxidant capacity (TEAC) and 2,4-DNP; 2,2-diphenyl-1-picrylhydrazyl (DPPH) methods, as previously reported by our group. [15][16][17] In all cases, the absorbance was measured in a Neo2 microplate reader (Biotek, Winooski, Vermont, U.S.A.) and the results were expressed as μM of Trolox equivalents (TE) per gram (g) of honey.…”

Flavonoids from Lycium barbarum Leaves Exhibit Anti-Aging Effects through the Redox-Modulation

“…The control group received 0.2% ( v/v ) DMSO and 5% ( v / v ) H 2 O, respectively. C. elegans dragged out of the plate or with extruded internal organs were considered as checked [ 15 ].…”