An observational retrospective study of odontogenic cyst´s and tumours over an 18-year period in a Portuguese population according to the new WHO Head and Neck Tumour classification

Abstract

Background Odontogenic cysts and tumours of the jaws represent one of the most prevalent groups of oral-maxillofacial lesions. We aimed to evaluate the clinical and pathological characteristics of a cohort of odontogenic cysts (OC) and odontogenic tumours (OT) of the jaws in a Portuguese population. Material and Methods This observational retrospective study analysed patients diagnosed with either an OC or OT of the jaws at a central hospital of Oporto, Portugal, between 1988 and 2006. Data collected from patients’ files included demographic, clinical, radiological and histopathological information. Recurrence was evaluated using univariate and multivariate analysis. Results The sample consisted of 397 patients, 231 males (58.2%) and 166 females (41.8%), with a mean-age of 36.7±17 years. Twenty-seven patients (6.8%) presented with more than one lesion providing a total of 433 lesions. There were 396 (91.5%) OC, mostly represented by radicular cysts (n=257;59.4%), dentigerous cysts (n=79;18.2%), or odontogenic keratocysts (n=50;11.5%). There were 37 (8.5%) OT, mostly represented by ameloblastomas (n=16;3.7%), and odontomas (n=9;2.1%). The most common initial clinical manifestation was swelling (n=224;51.7%). Recurrence was observed in 30 cases (6.9%), mostly in ameloblastomas (n=6;37.5%) and odontogenic keratocysts (n=12;24%). In the multivariate analysis the diagnosis classification of the lesion was the only independent and significant variable related with the recurrence ( P =0.04). Conclusions Radicular cysts were the most commonly occurring type of OC and ameloblastomas the most commonly occurring OT. Amelobastomas and odontogenic keratocysts were the lesions with the highest rates of recurrence. This large sample provides useful information about the frequency profile and characteristics of OC and OT over a period of 18 years, allowing valuable comparison with data from other countries. Key words: Odontogenic cysts and tumours, radicular cyst, dentigerous cyst, odontogenic keratocyst, ameloblastoma, recurrence.

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“…Furthermore, of the 368 odontogenic cyst patients, 222 (60.33%) were males and 146 (39.67%) were females. With a male-to-female ratio of about 1.52:1 (Tables 2 and 3), which was consistent with research performed in other countries, including Portugal, Brazil, Mexico, Italy, India, Kenya, Greece, Turkey, Italy, and Iran (ranging between 50.9 % and 64.4 %) [9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25]. In contrast, female predominance was significant in the Brazilian population [26] and among Indonesians [24].…”

“…Therefore, the most common type of odontogenic cyst in this study was radicular cysts. Similar results were found in most of the previous studies of different countries [18][19][20][21][22][23][24][25][26], while odontogenic keratocyst was the most predominant in the Brazil study [12]. Furthermore, Butt et al reported that dentigerous cysts (31%) were the most common type of odontogenic cysts, followed by radicular cysts (22%) in Kenya [17] with slight differences.…”

Unraveled roles of Cav1.2 in proliferation and stemness of ameloblastoma

“…Classification remains controversial due to the hallmarks of cysts and tumors both exist in OKC. Although AM and OKC are believed to originate from dental epithelial cells and share similar sites of presentation in the jawbone, they have distinct histopathological features and transcriptomic expression [ 2 , 3 ].…”

Gene polymorphisms in odontogenic keratocysts and ameloblastomas: A systematic review

“…Odontogenic keratocysts (OKC) and ameloblastomas are among the most common odontogenic lesions of the jaws (Monteiro et al., 2020). Although these two entities share a common embryogenic origin and some clinical features, there are substantial differences in terms of etiopathogenesis, treatment, and prognosis.…”

“…Odontogenic keratocysts (OKC) and ameloblastomas are among the most common odontogenic lesions of the jaws (Monteiro et al, 2020).…”