Gene polymorphisms in odontogenic keratocysts and ameloblastomas: A systematic review

Abstract

Objectives:The aim of this systematic review was to critically analyze available data on gene polymorphisms in odontogenic keratocysts (OKC) and ameloblastomas, including their possible relationship with clinical and histological features of these lesions. Materials and Methods: A comprehensive search of Web of Science Scopus, PubMed, Cochrane Central Register of Controlled Trials and EMBASE was conducted using relevant key terms and supplemented by a gray literature search. Quality assessment of included studies was performed using criteria from the Strengthening the Reporting of Genetic Association (STREGA) statement. Results: Ten studies were included in the final review. Survivin -31G/C, interleukin IL-1α -889 C/T, p53 codon 72 G/C, tumor necrosis factor TNFα (−308G>A) and itsreceptor TNF-R1 (36A>G), glioma-associated oncogene homolog 1 rs2228224 and matrix metalloproteinase 2 rs243865 gene polymorphisms were reported to be associated with OKC. For ameloblastomas, p53 codon 72 G/C, X-ray repair crosscomplementing protein 1-codons 194 and 399 and matrix metalloproteinase 9 rs3918242 gene polymorphisms were identified as risk factors. It was not possible to establish a relationship between specific polymorphisms and clinical and histological features of investigated lesions. Conclusions:Several gene polymorphisms might be considered as a risk factor for the development of these lesions. Future studies should investigate whether these polymorphisms might be used to identify patients with increased risk of recurrence or aggressive disease.

Polymorphisms in VDR, CYP27B1, CYP2R1, GC and CYP24A1 Genes as Biomarkers of Survival in Non-Small Cell Lung Cancer: A Systematic Review

“…The score obtained was expressed as a percentage ([points obtained/maximum points] × 100). Finally, the percentage was taken as a reference to classify the studies as high (>80%), moderate (50–80%), or low (<50%) quality, as reported in previous studies [ 40 , 41 , 42 ].…”

Associations of FOXP3 gene polymorphisms with susceptibility and severity of preeclampsia: A meta‐analysis

“…The STREGA checklist for case‐control studies includes 49 items, five of which are related to both cases and controls information. The STREGA score for each study was expressed as the percentage of the number of questions adequately reported in the study divided by the number of applicable questions 34 . According to the STREGA score, studies were categorized into high (>80% of the STREGA criteria achieved), moderate (50%‐80% of the STREGA criteria fulfilled), or low (<50% of the STREGA criteria met) quality level.…”

“…The quality of each study was assessed by Newcastle-Ottawa quality assessment scales (NOS), 32 adequately reported in the study divided by the number of applicable questions. 34 According to the STREGA score, studies were categorized into high (>80% of the STREGA criteria achieved), moderate (50%-80% of the STREGA criteria fulfilled), or low (<50% of the STREGA criteria met) quality level.…”

Expression of Matrix Metalloproteinases 7 and 9, Desmin, Alpha-Smooth Muscle Actin and Caldesmon, in Odontogenic Keratocyst Associated with NBCCS, Recurrent and Sporadic Keratocysts

“…The participation of metalloproteinases (MMPs, as MMP-1, MMP-7, MMP-9, MMP-13, and MMP-26) in the biological behavior and invasion mechanisms of OKCs lesions has been demonstrated in many articles [ 6 , 7 , 8 , 9 , 10 ]. They can modify the structural and functional components of the extracellular matrix (ECM).…”