An NBD-based colorimetric and fluorescent chemosensor for Zn2+ and its use for detection of intracellular zinc ions

Fluorescence signaling of Zn2+ levels in synthetic urine by dipicolylamine-armed hydroxynaphthalimide

“…Tel. : +82 2 820 5199; fax: +82 2 825 4736. small-molecule-based sensors have been devised using the fluorophores of fluorescein [13,14], coumarin [15,16], 7-nitrobenz-2-oxa-1,3-diazole (NBD) [17,18], quinoline [19], and naphthalimide [20]. The most frequently used ligating sites for the recognition of Zn 2+ ions are dipicolylamine (DPA), macrocyclic aza-crown-ethers, and iminodiacetate moieties [21].…”

Phosphorescent Sensor for Biological Mobile Zinc

“…31 Various zinc-specific receptors have been developed in order to tune the p K a 32–38 and zinc dissociation constant ( K d ) of the sensor, 39–43 representative examples of which include DPA (di(2-picolyl)amine), DPEN ( N , N -di(2-picolyl)ethylenediamine), TRPEN ( N , N , N′ -tris(2-picolyl)ethylenediamine), quinoline, 2,2′-bipyridine, polyalkylamine, and iminodiacetate. 44 Conjugating these zinc-specific receptors onto fluorescent chromophores such as fluorescein, 32–35,41,42,45–55 coumarin, 56,57 quinoline, 31,58–63 and 4-nitrobenzo-oxadiazole 64–66 has produced a variety of fluorescence turn-on 31,32,47,49,52,63,65–85 and ratiometric sensors. 49,56,61,86–110 Despite their attractive features, fluorescent zinc sensors have some significant drawbacks, especially intrinsic signal contamination by autofluorescence and scattered light, which increases background and diminishes signal fidelity.…”

Influence of multidentate N-donor ligands on highly electrophilic zinc initiator for the ring-opening polymerization of epoxides

“…Benzene-d 6 , toluene-d 8 , and chloroform-d (99.96% atom% D) were obtained from Aldrich, dried over sodium or CaH 2 , vacuum transferred, degassed and filtered prior to use. [69] and complexes 1aec [41] were synthesized according to the literature. Cyclohexene oxide (CHO) and propylene oxide (PO) were purchased from Aldrich and were distilled from CaH 2 under vacuum following three freezeepumpethaw cycles and stored at À37 C in a glovebox.…”