An isoflavone compound daidzein elicits myoblast differentiation and myotube growth

Lee, Sang-Jin; Vuong, Tuan Anh; Go, Ga-Yeon; Song, Yoojin; Lee, Seulah; Lee, Sooyeon; Kim, Shin-Woong; Lee, Jaecheol; Kim, Yong Kee; Seo, Dong Wan; Kim, Ki‐Hyun; Kang, Jong‐Sun; Bae, Gyu‐Un

doi:10.1016/j.jff.2017.09.016

Cited by 15 publications

(12 citation statements)

References 29 publications

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“…The promyogenic activity was mediated by two kinases, Akt and P38MAPK, which in turn activated the key myogenic transcription factor MyoD. Moreover, daidzein encouraged myotube growth via the activation of the Akt/mTOR/S6K pathway [ 92 ]. In high-fat diet-induced rats, chronic soy protein consumption resulted in improved muscle function, regardless of muscle mass or fiber cross-section area improvement [ 93 ].…”

Section: Polyphenols In Managing Muscle Atrophy and Muscle Healthmentioning

confidence: 99%

Polyphenols and Their Effects on Muscle Atrophy and Muscle Health

2021

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Skeletal muscle atrophy is the decrease in muscle mass and strength caused by reduced protein synthesis/accelerated protein degradation. Various conditions, such as denervation, disuse, aging, chronic diseases, heart disease, obstructive lung disease, diabetes, renal failure, AIDS, sepsis, cancer, and steroidal medications, can cause muscle atrophy. Mechanistically, inflammation, oxidative stress, and mitochondrial dysfunction are among the major contributors to muscle atrophy, by modulating signaling pathways that regulate muscle homeostasis. To prevent muscle catabolism and enhance muscle anabolism, several natural and synthetic compounds have been investigated. Recently, polyphenols (i.e., natural phytochemicals) have received extensive attention regarding their effect on muscle atrophy because of their potent antioxidant and anti-inflammatory properties. Numerous in vitro and in vivo studies have reported polyphenols as strongly effective bioactive molecules that attenuate muscle atrophy and enhance muscle health. This review describes polyphenols as promising bioactive molecules that impede muscle atrophy induced by various proatrophic factors. The effects of each class/subclass of polyphenolic compounds regarding protection against the muscle disorders induced by various pathological/physiological factors are summarized in tabular form and discussed. Although considerable variations in antiatrophic potencies and mechanisms were observed among structurally diverse polyphenolic compounds, they are vital factors to be considered in muscle atrophy prevention strategies.

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Section: Polyphenols In Managing Muscle Atrophy and Muscle Healthmentioning

confidence: 99%

Polyphenols and Their Effects on Muscle Atrophy and Muscle Health

2021

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“…This effect was demonstrated by increases in the number of C2C12 myotubes and the upregulation of MHC expression. Another study also showed the stimulatory effect of daidzein on myogenesis through MyoD, myogenin, and MHC, as well as its hypertrophic impact on muscle via the mTOR/p70S6K pathway (Lee et al, 2017b). Akt and p38 proteins were the primary mediators of these hypertrophic and myogenic effects of daidzein.…”

Section: Daidzeinmentioning

confidence: 90%

“…In TNF-astimulated C2C12 myotubes, the suppression of the promoter activity of MuRF1 in response to daidzein was primarily mediated by SIRT1 activation. Daidzein significantly increased the diameters of dexamethasonetreated C2C12 myotubes by upregulating the myogenic transcriptional factors, MyoD, myogenin, and MHC (Lee et al, 2017b). Furthermore, daidzein reduced LPS-induced expression of atrogin-1 in C2C12 myotubes (Shiota et al, 2015).…”

Section: Daidzeinmentioning

confidence: 93%

Flavonoids: nutraceutical potential for counteracting muscle atrophy

Kim

Hwang

2020

Food Sci Biotechnol

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Skeletal muscle plays a vital role in the conversion of chemical energy into physical force. Muscle atrophy, characterized by a reduction in muscle mass, is a symptom of chronic disease (cachexia), aging (sarcopenia), and muscle disuse (inactivity). To date, several trials have been conducted to prevent and inhibit muscle atrophy development; however, few interventions are currently available for muscle atrophy. Recently, food ingredients, plant extracts, and phytochemicals have received attention as treatment sources to prevent muscle wasting. Flavonoids are bioactive polyphenol compounds found in foods and plants. They possess diverse biological activities, including anti-obesity, anti-diabetes, anti-cancer, anti-oxidation, and anti-inflammation. The effects of flavonoids on muscle atrophy have been investigated by monitoring molecular mechanisms involved in protein turnover, mitochondrial activity, and myogenesis. This review summarizes the reported effects of flavonoids on sarcopenia, cachexia, and disuse muscle atrophy, thus, providing an insight into the understanding of the associated molecular mechanisms.

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“…Penicillium canescens, two species of Fusarium, and Paraphoma radicina produced daidzein, a natural isoflavone known from the Leguminosae plant family. This metabolite has been shown to elicit myoblast differentiation and myotube growth (Lee et al, 2017). Daidzein was previously found in Trichoderma sp., an endophytic fungus of Azadirachta indica (Xuan et al, 2014).…”

Section: Discussionmentioning

confidence: 92%

Endophytic Fungi of Native Salvia abrotanoides Plants Reveal High Taxonomic Diversity and Unique Profiles of Secondary Metabolites

et al. 2020

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Endophytic fungi are often embedded in their host's metabolic networks, which can result in alterations of metabolite production and higher amounts of active compounds in medicinal plants. This study reports the occurrence, diversity, and secondary metabolite profiles of endophytic fungi isolated from Salvia abrotanoides plants obtained from three geographically distinct sites in Iran. A total of 56 endophytic fungi were isolated from roots and leaves of S. abrotanoides; site-specificity and root-dominated colonization was found to be a general characteristic of the endophytes. Based on molecular identification, the endophytic fungi were classified into 15 genera. Mycelial extracts of these isolates were subjected to high-resolution mass spectrometry analyses and revealed a broad spectrum of secondary metabolites. Our results demonstrated that Penicillium canescens, P. murcianum, Paraphoma radicina, and Coniolariella hispanica are producers of cryptotanshinone, which is a main bioactive compound of S. abrotanoides. Moreover, it was shown that it can be produced independent of the host plant. The effect of exogenous gibberellin on S. abrotanoides and endophytic fungi was shown to have a positive effect on increasing the cryptotanshinone production in the plant as well as in endophytic fungi cultivated under axenic conditions. Our findings provide further evidence that endophytic fungi play an important role in the production plant bioactive metabolites. Moreover, they provide an exploitable basis to increase cryptotanshinone production in S. abrotanoides.

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An isoflavone compound daidzein elicits myoblast differentiation and myotube growth

Cited by 15 publications

References 29 publications

Polyphenols and Their Effects on Muscle Atrophy and Muscle Health

Polyphenols and Their Effects on Muscle Atrophy and Muscle Health

Flavonoids: nutraceutical potential for counteracting muscle atrophy

Endophytic Fungi of Native Salvia abrotanoides Plants Reveal High Taxonomic Diversity and Unique Profiles of Secondary Metabolites

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