An iodinated vasopressin (V1) antagonist blocks flank marking and selectively labels neural binding sites in golden hamsters

Ferris, Craig F.; Delville, Yvon; Grzonka, Zbigniew; Luber-Narod, Judith; Insel, Thomas R.

doi:10.1016/0031-9384(93)90085-t

Cited by 63 publications

(30 citation statements)

References 29 publications

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“…The initial, seminal finding that Avp microinjected into the medial preoptic-anterior hypothalamic area (MPOA-AH) results in a dose dependent increase in flank marking behavior (Ferris et al, 1984) set the framework for future studies in this species and was one of the first to induce a complex behavior by microinjection of a single neuropeptide. These effects of Avp on flank marking are attributed specifically to Avp's action via the Avpr1a since Avpr1a antagonists administered orally or injected into the MPOA-AH block Avp-facilitated flank marking behavior Ferris et al, 1993;Caldwell and Albers, 2003;Ferris et al, 2006). Similarly, aggression can be facilitated when Avp is microinjected into the AH Caldwell and Albers, 2004b) and inhibited when Avpr1a antagonists are microinjected there (Ferris and Potegal, 1988).…”

Section: Pharmacological and Behavioral Manipulationsmentioning

confidence: 99%

Vasopressin: Behavioral roles of an “original” neuropeptide

Caldwell

Lee

Macbeth

et al. 2008

Progress in Neurobiology

421

416

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Vasopressin (Avp) is mainly synthesized in the magnocellular cells of the hypothalamic supraoptic (SON) and paraventricular nuclei (PVN) whose axons project to the posterior pituitary. Avp is then released into the blood stream upon appropriate stimulation (e.g., hemorrhage or dehydration) to act at the kidneys and blood vessels. The brain also contains several populations of smaller, parvocellular neurons whose projections remain within the brain. These populations are located within the PVN, bed nucleus of the stria terminalis (BNST), medial amygdala (MeA) and suprachiasmatic nucleus (SCN).Since the 1950's, research examining the roles of Avp in the brain and periphery has intensified. The development of specific agonists and antagonists for Avp receptors has allowed for a better elucidation of its contributions to physiology and behavior. Anatomical, pharmacological and transgenic, including "knockout," animal studies, have implicated Avp in the regulation of various social behaviors across species.Avp plays a prominent role in the regulation of aggression, generally of facilitating or promoting it. Affiliation and certain aspects of pair-bonding are also influenced by Avp. Memory, one of the first brain functions of Avp that was investigated, has been implicated especially strongly in social recognition. The roles of Avp in stress, anxiety, and depressive states are areas of active exploration. In this review, we concentrate on the scientific progress that has been made on understanding the role of Avp in regulating of these and other behaviors across species, as well as discuss the implications for human behavior.

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Section: Pharmacological and Behavioral Manipulationsmentioning

confidence: 99%

Vasopressin: Behavioral roles of an “original” neuropeptide

Caldwell

Lee

Macbeth

et al. 2008

Progress in Neurobiology

421

416

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“…Syrian hamsters stand apart in that no trace of vasopressin-ir projections of the BNST and MeA can be found (Dubois-Dauphin et al 1989;Albers et al 1991). Ironically, the lateral septum of Syrian hamsters has vaso pressin binding sites (Ferris et al 1993) and is sensitive to behavioral effects of vasopressin (Irvin et al 1990). These variations in vasopressin/vasotocin pro jections may be exploited to reveal the processes underlying their sexual differen tiation and their functional significance.…”

Section: Homologous Sex Differences In Other Vertebratesmentioning

confidence: 99%

Studying neurotransmitter systems to understand the development and function of sex differences in the brain: the case of vasopressin

Vries¹,

Geert²

1995

Neurobiological Effects of Sex Steroid Hormones

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“…AVP binding sites in the AH were labeled as described previously (Ferris et al, 1993) and modified slightly for these studies. Animals (n ϭ 3) were killed by decapitation, and the brains were removed, frozen on dry ice, and stored at Ϫ80°C.…”

Section: Avp and 5-ht Receptor Binding Autoradiographymentioning

confidence: 99%

Vasopressin/Serotonin Interactions in the Anterior Hypothalamus Control Aggressive Behavior in Golden Hamsters

et al. 1997

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Studies in several species of rodents show that arginine vasopressin (AVP) acting through a V 1A receptor facilitates offensive aggression, i.e., the initiation of attacks and bites, whereas serotonin (5-HT) acting through a 5-HT 1B receptor inhibits aggressive responding. One area of the CNS that seems critical for the organization of aggressive behavior is the basolateral hypothalamus, particularly the anterior hypothalamic region. The present studies examine the neuroanatomical and neurochemical interaction between AVP and 5-HT at the level of the anterior hypothalamus (AH) in the control of offensive aggression in Syrian golden hamsters. First, specific V 1A and 5-HT 1B binding sites in the AH are shown by in vitro receptor autoradiography. The binding for each neurotransmitter colocalizes with a dense field of immunoreactive AVP and 5-HT fibers and putative terminals. Putative 5-HT synapses on AVP neurons in the area of the AH are identified by double-staining immunocytochemistry and laser scanning confocal microscopy. These morphological data predispose a functional interaction between AVP and 5-HT at the level of the AH. When tested for offensive aggression in a resident /intruder paradigm, resident hamsters treated with fluoxetine, a selective 5-HT reuptake inhibitor, have significantly longer latencies to bite and bite fewer times than vehicle-treated controls. Conversely, AVP microinjections into the AH significantly shorten the latency to bite and increase biting attacks. The action of microinjected AVP to increase offensive aggression is blocked by the pretreatment of hamsters with fluoxetine. These data suggest that 5-HT inhibits fighting, in part, by antagonizing the aggressionpromoting action of the AVP system. Two neurotransmitter systems implicated in the control of aggressive behavior are arginine vasopressin (AVP) and serotonin (5-HT). AVP is a neurochemical signal affecting numerous brain functions (DeWied, 1971;Cooper et al., 1979;Pittman et al., 1982;Fehm-Wolfsdorf et al., 1988;Dantzer and Bluthe, 1992), including aggression (Ferris and Potegal, 1988, Koolhaas et al., 1990Potegal and Ferris, 1990;Winslow et al., 1993; Delville et al., 1996a,b). For example, microinjection of AVP V 1A -receptor antagonist into the anterior hypothalamus (AH) of a hamster causes a dose-dependent inhibition of offensive aggression, i.e., initiated attacks and bites toward a conspecific placed into their home cage (Ferris and Potegal, 1988). Similarly, AVP receptor blockade in the AH significantly reduces aggression between hamsters paired together in a neutral arena .Although AVP facilitates offensive aggression, 5-HT is reported to have the opposite effect and diminishes aggressive behavior (for review, see Olivier and Mos, 1990). For example, rats show an increase in offensive aggression after treatment with neurotoxins that deplete 5-HT levels in the hypothalamus (Vergnes et al., 1988). Conversely, rats treated with eltoprazine, a 5-HT 1 receptor agonist, show a dose-dependent decrease in offensive aggressi...

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An iodinated vasopressin (V1) antagonist blocks flank marking and selectively labels neural binding sites in golden hamsters

Cited by 63 publications

References 29 publications

Vasopressin: Behavioral roles of an “original” neuropeptide

Vasopressin: Behavioral roles of an “original” neuropeptide

Studying neurotransmitter systems to understand the development and function of sex differences in the brain: the case of vasopressin

Vasopressin/Serotonin Interactions in the Anterior Hypothalamus Control Aggressive Behavior in Golden Hamsters

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