An iodinated liposomal computed tomographic contrast agent prepared from a diiodophosphatidylcholine lipid

Elrod, Don B.; Partha, Ranga; Danila, Delia; Casscells, S. Ward; Conyers, Jodie L.

doi:10.1016/j.nano.2008.06.007

Cited by 59 publications

(44 citation statements)

References 10 publications

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“…18 The conjugation of iodine to lipid results in low iodine:liposome ratio compared to our formulation, wherein the iodinated molecules are encapsulated within the core interior. Although not used in this study, liposomes with an even higher concentration of iodine (eg, 100 mg/ml) have been successfully used.…”

Section: Dovepressmentioning

confidence: 94%

Micro-CT imaging of breast tumors in rodents using a liposomal, nanoparticle contrast agent

Samei¹

2009

IJN

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A long circulating liposomal, nanoscale blood pool agent encapsulating traditional iodinated contrast agent (65 mg I/mL) was used for micro-computed tomography (CT) imaging of rats implanted with R3230AC mammary carcinoma. Three-dimensional vascular architecture of tumors was imaged at 100-micron isotropic resolution. The image data showed good qualitative correlation with pathologic findings. The approach holds promise for studying tumor angiogenesis and for evaluating anti-angiogenesis therapies.

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Section: Dovepressmentioning

confidence: 94%

Micro-CT imaging of breast tumors in rodents using a liposomal, nanoparticle contrast agent

Samei¹

2009

IJN

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“…Research essentially focuses [213,214] on the incorporation of iodinated organic compounds into NPs, with designs ranging from emulsions, [215][216][217][218] liposomes, [214,[219][220][221][222][223] and lipoproteins, [224,225] to insoluble nano objects, [214,[226][227][228] and polymeric NPs, [215,[229][230][231][232][233]; many of them have been successfully applied in vivo [28,56]. The purpose of these nanomaterials is to locally increase iodine concentrations, Some multimodal nanoparticles were doped with an iodinated compound and used to enhance X-ray contrast [216,224,234,235] as discussed in later on in the review.…”

Section: Iodinated Nanoparticlesmentioning

confidence: 99%

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

Trequesser¹,

Seznec²,

Delville³

2016

Nano Online

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The successful development of nanomaterials illustrates the considerable interest in the development of new molecular probes for medical diagnosis and imaging. Substantial progress was made in synthesis protocol and characterization of these materials whereas toxicological issues are sometimes incomplete. Nanoparticle-based contrast agents tend to become efficient tools for enhancing medical diagnostics and surgery for a wide range of 2 imaging modalities. Multimodal nanoparticles (NPs) are much more efficient than conventional molecular-scale contrast agents. They provide new abilities for in vivo detection and enhanced targeting efficiencies through longer circulation times, designed clearance pathways, and multiple binding capacities. Properly protected, they can safely be used for the fabrication of various functional systems with targeting properties, reduced toxicity and proper removal from the body. This review mainly describes the advances in the development of mono-to multimodal NPs and their in vitro and in vivo relevant biomedical applications ranging from imaging and tracking to cancer treatment. Besides specific applications for classical imaging, (MRI, PET, CT, US, PAI) are also mentioned less common imaging techniques such as terahertz molecular imaging (THMI) or ion beam analysis (IBA).Perspectives on multimodal theranostic NPs and their potential for clinical advances are also mentioned.

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“…Other CT molecular imaging agents contain bismuth sulfide, as well as composite ceramics containing iron oxide and lanthanide materials. Most CT molecular contrast agents are designed to incorporate a maximum number of x-ray-absorbing atoms into a nanoparticle, with designs ranging from emulsions (71)(72)(73) (Fig 6), liposomes (74), and lipoproteins (42) to polymeric nanoparticles (75,76). A key feature of many of these nanoparticle designs is their pharmacokinetics, which are often markedly different than those of small iodinated molecules in clinical use.…”

Section: Principles Of Molecular Ct Contrast Agentsmentioning

confidence: 99%

Molecular Body Imaging: MR Imaging, CT, and US. Part I. Principles

Kircher¹,

Willmann²

2012

Radiology

192

154

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An iodinated liposomal computed tomographic contrast agent prepared from a diiodophosphatidylcholine lipid

Cited by 59 publications

References 10 publications

Micro-CT imaging of breast tumors in rodents using a liposomal, nanoparticle contrast agent

Micro-CT imaging of breast tumors in rodents using a liposomal, nanoparticle contrast agent

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

Molecular Body Imaging: MR Imaging, CT, and US. Part I. Principles

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