An investigation of the antimicrobial and anti-inflammatory activities of crocodile oil

Buthelezi, S.B.N.; Southway, C.; Govinden, Usha; Bodenstein, Johannes; Toit, Karen du

doi:10.1016/j.jep.2012.06.040

Cited by 36 publications

(28 citation statements)

References 30 publications

(27 reference statements)

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“…[23], and Duarte and Araujo [24]. Moreover, no sign of inflammatory reactions (hemorrhage and edema) was seen in serum-treated group, which suggests the presence of activities of serum antibacterial agents and immunoglobulin [8,25,26]. The fibrin deposit was the marked inflammatory exudate in serum-treated group, which is similar to the results recorded by Al-Falahi et al .…”

Section: Resultssupporting

confidence: 83%

Histological assessment of the efficiency of rabbit serum in healing skin wounds

Majeed

Abood

2019

Vet World

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Aim:This study aimed to investigate the impact of rabbit serum on skin wound healing with the help of histological examination.Materials and Methods:A total of ten indigenous rabbits were used in this study. The animals were divided into two groups: control and serum- treated. The histological assessment was done with a paraffin embedding technique and the histological sections were stained with H&E stain.Results:Severe infiltration of polymorphonuclear leukocytes with severe fibrin deposits were seen in serum treated group at 2 days post-injury; at 7 days post-injury the changes revealed moderate fibroplasia, fibrin deposit and severe infiltration of both mononuclear and polymorphonuclear leukocytes; at 14 days post-injury, there were marked epithelization and dermal deposition of collagen fibers; and at 21 days post-injury, the epidermis completed epithelization and the dermis showed neither fibroplasia nor infiltration of mononuclear and polymorphonuclear leukocytes.Conclusion:The results indicated that rabbit’s serum can prevent wound infection, accelerate epithelialization and cutaneous regeneration with less granulation.

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Section: Resultssupporting

confidence: 83%

Histological assessment of the efficiency of rabbit serum in healing skin wounds

Majeed

Abood

2019

Vet World

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“…The use of crocodile oil though, has been documented in traditional healing in various ethnic groups in Africa, including South Africa, Madagascar and even China [ 5 ]. Antimicrobial effects and anti-inflammatory effects of crocodile oil has also been reported [ 5 ], but there is paucity of information in literature on the use of crocodile fats. Blood extracts of Crocodylus siamensis has also been reported to show considerable anti-inflammatory activities [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

Histomorphology, ultrastructure and fatty acid composition of the adipose tissue in pansteatitis, the potentials in understanding the underlying mechanism and diagnosis of pansteatitis in the Nile crocodile

et al. 2017

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BackgroundIn an effort to characterize the fat body and other adipose tissue in the Nile crocodile and the effects of pansteatitis on the structure and composition of the adipose tissue, we evaluated the regional variation in structure and fatty acid composition of healthy farmed crocodiles and those affected by pansteatitis.MethodsAdipose tissue samples were collected from the subcutaneous, visceral and intramuscular fat and the abdominal fat body of ten 4-year old juvenile crocodiles from Izinthaba Crocodile Farm, Pretoria, South Africa while pansteatitis samples were collected from visceral and intramuscular fat of crocodiles that had died of pansteatitis at the Olifant River, Mpumalanga, also in South Africa. Histomorphology, ultrastrustucture and fatty acid composition by fatty acid methyl ester (FAME) analysis were conducted.ResultsHistological examination showed regional variations in the adipose tissue especially in the collagen content of the ECM, tissue perfusion and division into lobes and lobules by fibrous capsule. Considerable fibrosis, mononuclear cell infiltration especially by macrophages and lymphocytes and toxic changes in the nucleus were observed in the pansteatitis samples.Regional variation in lipid composition especially in Myristoleic (C14:1), Erucic acid (C22:1n9), and Docosadienoic acid (C22:2n6) was observed. Most of the saturated and trans fatty acids were found in significant quantities in the pansteatitis samples, but had very low levels of the cis fatty acid and the essential fatty acids with C18 backbone.ConclusionThis study demonstrates that there exists some regional variation in histomorphology and fatty acid composition in the healthy adipose tissue of the Nile crocodile. It also showed that pansteatitis in the Nile crocodile might have been triggered by sudden change in energy balance from consumption of dead fish; and probable exposure to toxic environmental conditions with the evidence of up scaled monounsaturated long chain fatty acids composition and toxic changes in the leucocytes observed in pansteatitis in the present study.

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“…Crocodiles are wild animals with scientific research value, ecological value, and high economic value [56][57][58]. The fragmented skin on the crocodile head provides an appropriate example of skin debris research, similar to the scales of snakes, lizards and fishes that can protect themselves (Fig.…”

Section: Reptilesmentioning

confidence: 99%

Recent biomedical applications of bio-sourced materials

Elbaz

Gao

et al. 2018

Bio-des. Manuf.

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Natural anisotropic nanostructures occurring in several organisms have gained more and more attention because of their obvious advantages in sensitivity, stability, security, miniaturization, portability, online use, and remote monitoring. Due to the development of research on nature-inspired bionic structures and the demand for highly efficient, low-cost microfabrication techniques, an understanding of and the ability to replicate the mechanism of structural coloration have become increasingly significant. These sophisticated structures have many unique functions and are used in many applications. Many sensors have been proposed based on their novel structures and unique optical properties. Several of these bio-inspired sensors have been used for infrared radiation/thermal, pH, and vapor techniques, among others, and have been discussed in detail, with an intense focus on several biomedical applications. However, many applications have yet to be discovered. In this review, we will describe these nanostructured materials based on their sources in nature and various structures, such as layered, hierarchical, and helical structures. In addition, we discuss the functions endowed by these structures, such as superhydrophobicity, adhesion, and high strength, enabling them to be employed in a number of applications in biomedical fields, including cell cultivation, biosensors, and tissue engineering.

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An investigation of the antimicrobial and anti-inflammatory activities of crocodile oil

Cited by 36 publications

References 30 publications

Histological assessment of the efficiency of rabbit serum in healing skin wounds

Histological assessment of the efficiency of rabbit serum in healing skin wounds

Histomorphology, ultrastructure and fatty acid composition of the adipose tissue in pansteatitis, the potentials in understanding the underlying mechanism and diagnosis of pansteatitis in the Nile crocodile

Recent biomedical applications of bio-sourced materials

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