Acanthaceae plant Asteracantha longifolia (L.) Nees is used to make the ayurvedic medication ‘Kokilaaksha' and the Unani drug Talimakhana. The seeds are aphrodisiac, bitter, tonic, and sedative, and are used to treat blood problems. Antitumor, hypoglycemic, aphrodisiac, antibacterial, free radical scavenging and lipid peroxidation, hepatoprotective, and haematopoietic activity are all known properties of the plant. Lupeol, stigmasterol, butelin, fatty acids, and alkaloids are all found in it. The focus of this review paper is on Talimakhana's phytochemical, pharmacological, and other relevant characteristics.