Hygrophila spinosa : A comprehensive review

Abstract

Hygrophila spinosa T Ander, belonging to the family Acanthaceae, is a promising medicinal plant with great economic potential. The medicinal value of H. spinosa has been appreciated in the ancient medical literature. The plant contains terpenoids, alkaloids, flavonoids, and is traditionally known as an aphrodisiac, renal tonic, and for its health-promoting properties. The plant is cultivated throughout India. However, systematic information on the different aspects of this species is not available. In this review, an attempt has been made to present this information.

Protective effect of Hygrophila spinosa against cisplatin induced nephrotoxicity in rats

“…[10] Hepatoprotective activity of seeds of Hygrophila auriculata in thioacetamide, paracetamol-induced liver damage in rats, ethylene glycol induced nephrolithiasis in rat. [111213] A literature survey revealed that there are no scientific studies carried out regarding H. spinosa in CP induced nephrotoxicity. Hence the present study is focused to evaluate the nephroprotective and antioxidant potentials of the plant against CP induced nephrotoxicity in rats.…”

Instrumental evaluation of anti-aging effects of cosmetic formulations containing palmitoyl peptides, Silybum marianum seed oil, vitamin E and other functional ingredients on aged human skin

“…However, palmitoyl peptides, the modified formation of these small peptides, have potential anti-aging functions (14). S. marianum seed oil contains silymarin flavonoids including silibinin, silidianin and silichrystin, which may exert antioxidative activity (15), and show potential anti-aging effects as a cosmetic cream formulation by decreasing transepidermal water loss and surface wrinkles (16). Vitamin E has been demonstrated to be an antioxidant in numerous studies (17)(18)(19).…”

Antioxidant and hepatoprotective activity of milk thistle (Silybum marianum L. Gaertn.) seed oil

“…Silymarin, the primary active ingredient in the seeds, has been extensively studied for hepatoprotective effects and several putative hepatoprotective mechanisms, including antioxidation and inhibition of lipid peroxidation [12,13], as well as anti-inflammatory [14] and anti-fibrotic effects [15], have been recorded. Although silymarin is orally absorbed, it has very poor bioavailability due to its lower water solubility [16]. Consequently, research efforts have been aimed at developing novel drug delivery systems that can improve the performance of silymarin activity [17][18][19].…”