An investigation of diclofenac sodium release from cetylpyridinium chloride-modified natural zeolite as a pharmaceutical excipient

Surface modified natural zeolite as a carrier for sustained diclofenac release: A preliminary feasibility study

“…This increase can be explained if we consider that in DWPB there M a n u s c r i p t 15 is greater competition between the drug and the phosphate buffer, while in DWNB, the lower ion concentration in the medium favours DS adsorption. However, if we compare the results of the maximum DS loaded on the SMNZ surface with that of the AEC experimentally evaluated, it is clear that in the case of DWNB, the value of the maximum loading capacity (0.23 meq/g) is greater than the AEC, indicating that DS is not only exchanged by anionic sites of the SMNZ, but also enters the patchy bilayer, as previously suggested by Krajišnik et al [17].…”

“…A c c e p t e d M a n u s c r i p t 19 our previous observation that the higher SMNZ loading capacity compared to AEC indicates that some drug molecules may cross the patchy bilayer and be internalized within the SMNZ [17].…”

“…For this purpose, modification of the zeolite surface, according to external cation exchange capacity of the zeolite-rich rock, was performed, using cetylpyridinium chloride (CP-Cl) as cationic surfactants , while diclofenac sodium (DS) was used as the model drug since it has been already used in previous similar studies and since it possesses numerous pharmaceutical applications for both oral and topical route of administration [15][16][17]. In actual fact, DS is a non-steroidal antiinflammatory drug (NSAID) used to reduce inflammation and/or as an analgesic, reducing pain in certain conditions.…”

Rheological and Viscoelastic Properties of Novel Sunflower Oil‐Span 40‐Biopolymer–Based Bigels and Their Role as a Functional Material in the Delivery of Antimicrobial Agents

“…The pseudo-Fickian release was considered as a complex release mechanism, which was dependent on various other factors such as swelling and erosion of polymers, porosity, and drug diffusion. 57,58 The antimicrobial efficiency of the drug-loaded bigels (AGM, GGM, and XGM) and MR gels against E. coli was expressed in terms of zone of inhibitions (Table V). AG, GG, and XG bigels were taken as negative controls.…”

Drug Release Mechanism of Slightly Soluble Drug from Nanocomposite Matrix Formulated with Zeolite/ Hydrotalcite as Drug Carrier

“…chitosan, gelatin and alginate) and prolonged the drug releases [10]. Diclofenac sodium has been loaded into natural ZLT and the drug released for 8 h [11].…”