An Investigation of Antibacterial Resistance Patterns Among Acinetobacter baumannii and Pseudomonas aeruginosa Isolates Collected from Intensive Care Units of a University-Affiliated Hospital in Ahvaz, Iran

Izadpour, Farrokh; Ranjbari, Nastaran; Aramesh, Mohammad Reza; Moosavian, Mojtaba; ShahAli, Shiva; Larki, Farzaneh; Tabesh, Hamed; Morvaridi, Afrooz

doi:10.5812/jjm.35624

Cited by 7 publications

(4 citation statements)

References 12 publications

(23 reference statements)

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“…Of all A. baumannii cases in our study, 84% were resistant (MDR: 20% and XDR: 64%); it is consistent with the reports on the prevalence of resistant Acinetobacter strains in Imam Khomeini hospital in Ahvaz in 2013 (81.3%) and with a meta-analysis conducted in Iran from 2007 to 2015 to determine the prevalence of imipenem resistant Acinetobacter that was 55% (6,21).…”

Section: Discussionsupporting

confidence: 91%

Risk Factors for Resistance and Mortality in Patients with Extensively Resistant Acinetobacter Bacteremia in Taleghani Hospital in Tehran, Iran

Abolghasemi

Madadi

Mardani

2018

Arch Pediatr Infect Dis

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Objectives: This study describes the antibiotic resistance pattern in patients with Acinetobacter bacteremia and investigates the factors leading to extensively drug resistance (XDR) and mortality. Methods: This descriptive analytical study was conducted in patients with Acinetobacter bacteremia between February 2014 and February 2015. The microorganisms were identified with conventional bacteriological methods and then, following the clinical and laboratory standards institute (CLSI) recommendations, susceptibility testing was performed on all isolates. Moreover, we used electronic records to extract the patients' data and analyzed them using Chi-square test or Fisher's exact test and T-Test. Results: Among the influencing factors, the severity of clinical symptoms at the time of admission, longer duration of hospitalization especially in the ICU, and use of invasive devices such as ventilator had a significant relationship with the occurrence of resistance and mortality in the patients. In addition, the central venous catheterization and history of drug resistance such as XDR were associated with mortality. Conclusions: Given the increasing prevalence of XDR Acinetobacter strains causing resistant nosocomial infection, especially in immunocompromised patients, it is necessary to reduce the risk factors leading to drug resistance and mortality. Furthermore, early administration of empiric antibiotic therapy can have a good effect on the outcomes.

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Section: Discussionsupporting

confidence: 91%

Risk Factors for Resistance and Mortality in Patients with Extensively Resistant Acinetobacter Bacteremia in Taleghani Hospital in Tehran, Iran

Abolghasemi

Madadi

Mardani

2018

Arch Pediatr Infect Dis

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“…This results show that the some of the strains that carry the blaIMP gene may not be detectable by MHT phenotypic test or other genes and mechanisms involved in the resistant to carbapenems. Emergence of multi-drug resistant P. aeruginosa, especially to carbapenems and aminoglycosides, and the high prevalence of virulence traits in our study could be regarded as an alarming situation (32,33). Antibiotic resistant pathogenic bacteria can come from the variety of foods (34).…”

Section: Discussionmentioning

confidence: 73%

Occurrence of a Multidrug Resistant Pseudomonas aeruginosa Strains in Hospitalized Patients in Southwest of Iran: Characterization of Resistance Trends and Virulence Determinants

Jahromi

Mardaneh

Sharifi

et al. 2018

Jundishapur J Microbiol

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Background: Pseudomonas aeruginosa is a Gram negative ubiquitous opportunistic organism and one of the more problematic drug-resistant pathogens encountered today. Objectives: The aims of the current multicenter research were to assess antibiotic resistance profiles, carbapenemase production, and detection of antibiotic resistance IMP gene as well as virulence factors genes including exoA, algD, lasB, and plcH among the clinical isolates of P. aeruginosa. Methods: A total of 80 nonduplicate isolates of P. aeruginosa were recovered from inpatients. Bacterial identification was done by standard diagnostic tests. Species was confirmed by detection of the exoA gene using the PCR technique. Antimicrobial susceptibility test was performed according to the Clinical and Laboratory Standards Institute (CLSI) guidelines. Carbapenemase production among the isolates was determined by the modified Hodge test. Virulence genes were detected by PCR. Results: A total of 42 (52.5%) isolates recovered from wound specimens. Colistin was the most effective antibiotic against isolates (97.5% isolates were susceptible) and levofloxacin was the least effective drug (67.5% isolates were resistant). The most common antibiotic resistance pattern was CIPR-CPMR-GEMR (47 isolates). In total, 47 (58.75%) isolates were identified as multidrug resistance (MDR), while 30% of isolates were carbapenemase producer (MHT+). Among studied isolates, plcH+ and lasB+ genotypes (100% isolates) were the most common virulence gene patterns. Of 80 P. aeruginosa isolates, 39 (48.75%) showed algD+, plcH+, lasB+, and IMP+ genotype. The blaIMP resistance gene was detected in all MHT positive and MDR isolates. Conclusions: In our study, the emergence of potentially highly pathogenic and carbapenem-resistant strains in joining with a MDR phenotype is alarming, as a feasible outcome would be a severe clinical result concomitant with critical restrictions in antibiotic therapy.

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“…Both these two factors were most probably increased infection with CR-KP in our intensive care units. In our study, multidrug-resistant A. baumanii isolates were the most common cause of infections among our patients in ICUs as it has been recoded worldwide [13][14][15][16]. The increase in antibiotic resistance rates among A. baumanii isolates was significant (Table 2-3).…”

Section: Discussionmentioning

confidence: 91%

Antibiotic resistance rates among bacterial isolates from infected patients of intensive care unit over the period (2011-2016) in Bursa, Turkey

Gecgel

Demircan

2017

int. arab. j antimicrob. agents

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Background: The aims of this study were to evaluate the microbiological datas for effective infection control and specific antimicrobial stewardship and to report the epidemiology of ICU-acquired infections and the local antimicrobial resistance of pathogen microorganisms. Methods: Datas were collected between January 2011-October 2016 retrospectively from the cardiology and cardiovascular surgery patients. The identification and antimicrobial susceptibility analyses in clinical isolates of pathogen microorganisms were determined by the automatic device system. Results: Klebsiella pneumoniae was detected increasingly resistant to imipenem (IMP) significantly (p=0.048). Acinetobacter baumanii was found increasingly resistant to amikacin (AN), gentamicin (GN), trimethoprim-sulfamethoxazole (SXT) and tetracycline (TE) significantly (p=0.045, p=0.030, p=0.006, p=0.027). There was a significantly decrease in the resistant rates of IMP, piperacillin-tazobactam (TPZ), meropenem (MEM) and ciprofloxacin (CIP) for Pseudomonas spp. (p=0.048). In all of the gram-negative microorganisms, significantly increasing resistance rates to cefepime (CEP) was detected (p=0.015). In all of the gram-positive microorganisms, significantly decreasing resistance rates to teicoplanin (TEC) was also detected (p=0.034). Conclusion: As a result, the inadequacy of infection control measures such as hand hygiene and patient isolation to prevent transmission between patients has increased the carbapenem-resistant Klebsiella pnemoniae (CR-KP) ratio, which is frequently found in recent years in our hospital. However, preferring preemptive treatment as a result of cooperation with microbiology laboratory instead of empirical treatment with antibiotics such as carbapenem and vancomycin caused the decrease in the resistance rates of resistant microorganism.

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An Investigation of Antibacterial Resistance Patterns Among Acinetobacter baumannii and Pseudomonas aeruginosa Isolates Collected from Intensive Care Units of a University-Affiliated Hospital in Ahvaz, Iran

Cited by 7 publications

References 12 publications

Risk Factors for Resistance and Mortality in Patients with Extensively Resistant Acinetobacter Bacteremia in Taleghani Hospital in Tehran, Iran

Risk Factors for Resistance and Mortality in Patients with Extensively Resistant Acinetobacter Bacteremia in Taleghani Hospital in Tehran, Iran

Occurrence of a Multidrug Resistant Pseudomonas aeruginosa Strains in Hospitalized Patients in Southwest of Iran: Characterization of Resistance Trends and Virulence Determinants

Antibiotic resistance rates among bacterial isolates from infected patients of intensive care unit over the period (2011-2016) in Bursa, Turkey

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