An investigation into the potential action of polyphenols against human Islet Amyloid Polypeptide aggregation in type 2 diabetes

Mahboob, Anns; Senevirathne, Degiri Kalana Lasanga; Paul, Pradipta; Nabi, Faisal; Khan, Rizwan Hasan; Châari, Ali

doi:10.1016/j.ijbiomac.2022.11.038

Cited by 11 publications

(7 citation statements)

References 210 publications

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“…A countless number of studies unveiling the antidiabetic properties, including early preventive, disease course modifying, and complication limiting effects, of individual nutrients and phytochemicals that are ubiquitously present in BP from different botanical and geographical origins have been published so far. This includes, for example, nutrients including vitamins such as groups B [ 241 , 242 , 243 ], C [ 244 , 245 , 246 ], D [ 247 , 248 , 249 ], and E [ 128 , 250 , 251 ], oligo-elements and other minerals [ 252 , 253 , 254 ], and lipids such as unsaturated fatty acids [ 255 , 256 , 257 ] and phytosterols [ 63 , 258 , 259 ], as well as other phytochemicals including polyphenols such as phenolic acids, flavonoids, and stilbenes (very recent and comprehensive reviews of preclinical and clinical evidence can be found in [ 260 , 261 , 262 , 263 , 264 , 265 , 266 ]). Despite the substantial amount of experimental and clinical evidence of all these BP compounds in the complex pathophysiology of diabetes and in its interaction with other comorbidities, the possible synergistic potential and real clinical outcome of these compounds, which are always combined in BP, have generally been omitted in research and must be further studied by in vivo experiments, and subsequently verified and objectively assessed by clinical studies.…”

Section: Resultsmentioning

confidence: 99%

Translational Research on Bee Pollen as a Source of Nutrients: A Scoping Review from Bench to Real World

Kacemi,

Campos

2023

Nutrients

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The emphasis on healthy nutrition is gaining a forefront place in current biomedical sciences. Nutritional deficiencies and imbalances have been widely demonstrated to be involved in the genesis and development of many world-scale public health burdens, such as metabolic and cardiovascular diseases. In recent years, bee pollen is emerging as a scientifically validated candidate, which can help diminish conditions through nutritional interventions. This matrix is being extensively studied, and has proven to be a very rich and well-balanced nutrient pool. In this work, we reviewed the available evidence on the interest in bee pollen as a nutrient source. We mainly focused on bee pollen richness in nutrients and its possible roles in the main pathophysiological processes that are directly linked to nutritional imbalances. This scoping review analyzed scientific works published in the last four years, focusing on the clearest inferences and perspectives to translate cumulated experimental and preclinical evidence into clinically relevant insights. The promising uses of bee pollen for malnutrition, digestive health, metabolic disorders, and other bioactivities which could be helpful to readjust homeostasis (as it is also true in the case of anti-inflammatory or anti-oxidant needs), as well as the benefits on cardiovascular diseases, were identified. The current knowledge gaps were identified, along with the practical challenges that hinder the establishment and fructification of these uses. A complete data collection made with a major range of botanical species allows more robust clinical information.

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Section: Resultsmentioning

confidence: 99%

Translational Research on Bee Pollen as a Source of Nutrients: A Scoping Review from Bench to Real World

Kacemi,

Campos

2023

Nutrients

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“… 398 However, the results from clinical trials indicated that adjunct medicines showed modest efficacy in preventing or treating diabetes. 399 A high throughput cell-based screening assay is now used to screen small-molecular activators for the Nrf2/Keap1/ARE pathway. 400 New antioxidants would be found to alleviate oxidative stress and inflammation in type 2 diabetes.…”

Section: Diabetesmentioning

confidence: 99%

Multifunctional nanoparticle-mediated combining therapy for human diseases

Li,

Peng,

Zoulikha

et al. 2024

Sig Transduct Target Ther

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Combining existing drug therapy is essential in developing new therapeutic agents in disease prevention and treatment. In preclinical investigations, combined effect of certain known drugs has been well established in treating extensive human diseases. Attributed to synergistic effects by targeting various disease pathways and advantages, such as reduced administration dose, decreased toxicity, and alleviated drug resistance, combinatorial treatment is now being pursued by delivering therapeutic agents to combat major clinical illnesses, such as cancer, atherosclerosis, pulmonary hypertension, myocarditis, rheumatoid arthritis, inflammatory bowel disease, metabolic disorders and neurodegenerative diseases. Combinatorial therapy involves combining or co-delivering two or more drugs for treating a specific disease. Nanoparticle (NP)-mediated drug delivery systems, i.e., liposomal NPs, polymeric NPs and nanocrystals, are of great interest in combinatorial therapy for a wide range of disorders due to targeted drug delivery, extended drug release, and higher drug stability to avoid rapid clearance at infected areas. This review summarizes various targets of diseases, preclinical or clinically approved drug combinations and the development of multifunctional NPs for combining therapy and emphasizes combinatorial therapeutic strategies based on drug delivery for treating severe clinical diseases. Ultimately, we discuss the challenging of developing NP-codelivery and translation and provide potential approaches to address the limitations. This review offers a comprehensive overview for recent cutting-edge and challenging in developing NP-mediated combination therapy for human diseases.

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“…Several polyphenols such as rosmarinic acid, ferulic acid, epigallocatechin gallate, and resveratrol, among many others, can interfere with the formation of fibrillar structures and thus avoid β-cell death [33,34]. Insulin receptor (IR) is a tyrosine kinase receptor, which is autophosphorylated upon insulin binding and it is expressed in all tissues.…”

Section: β-Cell Dysfunction and Deathmentioning

confidence: 99%

The Multifaceted Actions of Polyphenols in the Management of Type-2 Diabetes Mellitus

González¹,

Lindner²,

Schneider³

et al. 2023

Preprint

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Type-2 diabetes mellitus is recognized as a serious public health concern with a considerable impact on human life, long-term health expenditures, and substantial health losses. In this context, the use of dietary polyphenols to prevent and manage Type 2 diabetes mellitus is widely documented. These dietary compounds exert their beneficial effects by several actions, including the protection of pancreatic islet β-cell, the antioxidant capacities of these molecules, their effects on insulin secretion and actions, the regulation of intestinal microbiota, and their contribution to ameliorating diabetic complications, particularly those of vascular origin. In the present review, we intend to highlight these multifaceted actions and the molecular mechanisms by which these plant-derived secondary metabolites exert their beneficial effects on type-2 diabetes patients.

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An investigation into the potential action of polyphenols against human Islet Amyloid Polypeptide aggregation in type 2 diabetes

Cited by 11 publications

References 210 publications

Translational Research on Bee Pollen as a Source of Nutrients: A Scoping Review from Bench to Real World

Translational Research on Bee Pollen as a Source of Nutrients: A Scoping Review from Bench to Real World

Multifunctional nanoparticle-mediated combining therapy for human diseases

The Multifaceted Actions of Polyphenols in the Management of Type-2 Diabetes Mellitus

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