An Introduction to Basic Pharmacokinetics

Loucks, Jennifer; Yost, Sarah E.; Kaplan, Bruce

doi:10.1097/tp.0000000000000754

Cited by 5 publications

(8 citation statements)

References 21 publications

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“…The specific polyphenolic content of their plasma at different time points was determined by LC-ESI-MS/MS under the experimental conditions described above. For each phenolic compound that has been detected the following pharmacokinetic parameters have been calculated: i) maximum concentration (Cmax), ii) time required to achieve maximum concentration (Tmax), iii) area under the curve (AUC), iv) half-life (t1/2), and v) elimination rate constant (Ke), according to 56 and using PK Functions for Microsoft Excel by Joel I. Usansky (http://www.boomer.org).…”

Section: Methodsmentioning

confidence: 99%

Significant metabolic improvement by a water extract of olives: animal and human evidence

Peroulis

Androutsopoulos

Notas

et al. 2017

Preprint

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Section: Methodsmentioning

confidence: 99%

Significant metabolic improvement by a water extract of olives: animal and human evidence

Peroulis

Androutsopoulos

Notas

et al. 2017

Preprint

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“…Pharmacokinetics and pharmacodynamics are complex disciplines that utilize advanced mathematical principles that practitioners sometimes find challenging to comprehend. However, these two branches of pharmacology are pivotal in understanding ways to enhance efficacy and decrease harm for any exogenous substance prescribed (46), thus critical to clinical drug delivery. Pharmacokinetic analysis and simulation is the established approach to guide pharmaceutical dosing and frequency since it outlines a substance's concentration time course within the body (46).…”

Section: Basic Pharmacokinetic Concepts and Modelsmentioning

confidence: 99%

“…However, these two branches of pharmacology are pivotal in understanding ways to enhance efficacy and decrease harm for any exogenous substance prescribed (46), thus critical to clinical drug delivery. Pharmacokinetic analysis and simulation is the established approach to guide pharmaceutical dosing and frequency since it outlines a substance's concentration time course within the body (46). Pharmacodynamics, on the other hand, illustrate the dose-related effect of a substance in the body over time (46).…”

Section: Basic Pharmacokinetic Concepts and Modelsmentioning

confidence: 99%

“…Pharmacokinetic analysis and simulation is the established approach to guide pharmaceutical dosing and frequency since it outlines a substance's concentration time course within the body (46). Pharmacodynamics, on the other hand, illustrate the dose-related effect of a substance in the body over time (46).…”

Section: Basic Pharmacokinetic Concepts and Modelsmentioning

confidence: 99%

“…Absorption, distribution, metabolism, and excretion form the classic principles which make up the "ADME" acronym that describes PK (47). Absorption is the process where a substance travels from the site of administration to the site of measurement (46), while bioavailability refers to the degree and rate that an active substance is absorbed and present at the site of action (48). During and after the absorption phase, distribution occurs when the substance travels to and from the site of measurement (46).…”

Section: Basic Pharmacokinetic Concepts and Modelsmentioning

confidence: 99%

See 2 more Smart Citations

Understanding Volume Kinetics: The Role of Pharmacokinetic Modeling and Analysis in Fluid Therapy

et al. 2020

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Fluid therapy is a rapidly evolving yet imprecise clinical practice based upon broad assumptions, species-to-species extrapolations, obsolete experimental evidence, and individual preferences. Although widely recognized as a mainstay therapy in human and veterinary medicine, fluid therapy is not always benign and can cause significant harm through fluid overload, which increases patient morbidity and mortality. As with other pharmaceutical substances, fluids exert physiological effects when introduced into the body and therefore should be considered as “drugs.” In human medicine, an innovative adaptation of pharmacokinetic analysis for intravenous fluids known as volume kinetics using serial hemoglobin dilution and urine output has been developed, refined, and investigated extensively for over two decades. Intravenous fluids can now be studied like pharmaceutical drugs, leading to improved understanding of their distribution, elimination, volume effect, efficacy, and half-life (duration of effect) under various physiologic conditions, making evidence-based approaches to fluid therapy possible. This review article introduces the basic concepts of volume kinetics, its current use in human and animal research, as well as its potential and limitations as a research tool for fluid therapy research in veterinary medicine. With limited evidence to support our current fluid administration practices in veterinary medicine, a greater understanding of volume kinetics and body water physiology in veterinary species would ideally provide some evidence-based support for safer and more effective intravenous fluid prescriptions in veterinary patients.

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Significant metabolic improvement by a water extract of olives: animal and human evidence

et al. 2018

View full text Add to dashboard Cite

show abstract

An Introduction to Basic Pharmacokinetics

Cited by 5 publications

References 21 publications

Significant metabolic improvement by a water extract of olives: animal and human evidence

Significant metabolic improvement by a water extract of olives: animal and human evidence

Understanding Volume Kinetics: The Role of Pharmacokinetic Modeling and Analysis in Fluid Therapy

Significant metabolic improvement by a water extract of olives: animal and human evidence

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