An intrapulmonary teratoma associated with bronchiectasia containing various kinds of primordium: a case report and review of the literature

Abstract

An intrapulmonary teratoma (IPT), multiloculated and bronchiectatic, with two polyps inside a 23-year-old man is reported. The IPT, a very rare benign cystic lesion, was communicating with segmental bronchus and was removed by a segmental resection from the upper lobe of the left lung. The teratoma contained various kinds of primordial derivatives, such as mesoderm, ectoderm, and endoderm. Though 65 cases of IPT have been reported in the literature (1839-1996), in the present case there were over 15 germ derivatives, the largest number reported to date. The tumor contained thymic tissue, apart from mediastinum, which may be significant in relation to the pathogenesis of IPT. Clinical manifestations, age, and gender distributions and the kind of germ cell derivatives are discussed.

Thymic Teratoma or Thymic Remnant Attached to Mediastinal Teratoma? The Cellular Origin of Mediastinal Teratomas Revisited

“…It has been demonstrated that teratomas may arise within the thymus even if they are located ectopically in lung tissue, and it was proposed that thymic tissue was not a component of the tumor but was the true cellular origin of the teratoma (4). Additionally, the presence of thymic tissue within the wall of the intrapulmonary teratoma was found to be suggestive for a possible cellular origin from the third pharyngeal pouch (3,5).…”

An unusual case of pulmonary hamartoma with predominant bronchial mucous glands in the peripheral lung

“…Other biphasic tumors such as intrapulmonary teratoma (IPT) or pleomorphic adenoma (PA) of the lung could be ruled out. IPT is an extremely rare germ cell tumor, consisting of tissues derived from more than one embryonic germ layer at varying levels . IPT is cystic and multiloculated, but may rarely be predominantly solid .…”

“…IPT is an extremely rare germ cell tumor, consisting of tissues derived from more than one embryonic germ layer at varying levels. 18 IPT is cystic and multiloculated, but may rarely be predominantly solid. 18,19 Unlike typical IPT, our case was a solid nodule and did not have any components of non-pulmonary origin.…”

“…18 IPT is cystic and multiloculated, but may rarely be predominantly solid. 18,19 Unlike typical IPT, our case was a solid nodule and did not have any components of non-pulmonary origin. PA of the lung is also an extremely rare tumor, which arises in association with a bronchus or unrelated to it in the peripheral lung.…”

Large mixed germ cell tumor in a young patient presenting as an intrapulmonary mass

“…In our case, the tumor was well circumscribed without frank infiltration of adjacent tissue. Intrapulmonary teratomas are very rare and, like mediastinal ones, are thought to derive from ectopic thymic tissue (third pharyngeal pouch) [3,7,12,27]. Most of them occur in the first two to four decades of life and predominantly in the upper lobe and on the left side [11,23,29,31,32,37].…”