An integrative method to increase the reliability of conventional double emulsion method

Mashhadian, Ali; Afjoul, Homa; Shamloo, Amir

doi:10.1016/j.aca.2022.339523

Cited by 8 publications

(6 citation statements)

References 73 publications

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“…Double emulsification typically involves initially dispersing one liquid into another immiscible liquid to create a primary emulsion, which can be of the water-in-oil (W/O) or oil-in-water (O/W) type. This primary emulsion is then further dispersed into a third immiscible liquid to form a more complex emulsion, such as W/O/W or O/W/O, leading to the production of microspheres through solvent removal or droplet solidification [ 31 ] ( Figure 2 a). For instance, Xiong et al utilized the W1/O/W2 double emulsion method to fabricate porous PLGA microspheres containing artemisinin, with ammonium bicarbonate serving as a pore-forming agent [ 28 ].…”

Section: Polymer Microspheres Overviewmentioning

confidence: 99%

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Polymer Microspheres and Their Application in Cancer Diagnosis and Treatment

Zhai,

Wu,

Liao

et al. 2024

IJMS

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Cancer is a significant global public health issue with increasing morbidity and mortality rates. To address this challenge, novel drug carriers such as nano-materials, liposomes, hydrogels, fibers, and microspheres have been extensively researched and utilized in oncology. Among them, polymer microspheres are gaining popularity due to their ease of preparation, excellent performance, biocompatibility, and drug-release capabilities. This paper categorizes commonly used materials for polymer microsphere preparation, summarizes various preparation methods (emulsification, phase separation, spray drying, electrospray, microfluidics, and membrane emulsification), and reviews the applications of polymer microspheres in cancer diagnosis, therapy, and postoperative care. The current status and future development directions of polymer microspheres in cancer treatment are analyzed, highlighting their importance and potential for improving patient outcomes.

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Section: Polymer Microspheres Overviewmentioning

confidence: 99%

“…This results in microspheres with a more uniform particle size and morphology compared to single emulsification. However, the size distribution of the microspheres still tends to be quite broad overall [ 31 ].…”

Section: Polymer Microspheres Overviewmentioning

confidence: 99%

Polymer Microspheres and Their Application in Cancer Diagnosis and Treatment

Zhai,

Wu,

Liao

et al. 2024

IJMS

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Section: Preparation Of Microspheresmentioning

confidence: 99%

Application of Biomedical Microspheres in Wound Healing

Yang

Zhang

Gan

et al. 2023

IJMS

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Tissue injury, one of the most common traumatic injuries in daily life, easily leads to secondary wound infections. To promote wound healing and reduce scarring, various kinds of wound dressings, such as gauze, bandages, sponges, patches, and microspheres, have been developed for wound healing. Among them, microsphere-based tissue dressings have attracted increasing attention due to the advantage of easy to fabricate, excellent physicochemical performance and superior drug release ability. In this review, we first introduced the common methods for microspheres preparation, such as emulsification-solvent method, electrospray method, microfluidic technology as well as phase separation methods. Next, we summarized the common biomaterials for the fabrication of the microspheres including natural polymers and synthetic polymers. Then, we presented the application of the various microspheres from different processing methods in wound healing and other applications. Finally, we analyzed the limitations and discussed the future development direction of microspheres in the future.

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“…8,9 However, conventional droplet preparation techniques often have disadvantages such as low monodispersity, poor controllability, and high energy consumption. 10 Recently, microfluidics has become a promising technology with its advantages of high controllability, stability, and high packaging efficiency. 11 To date, coflowing, flow focusing, T-junction, and crossjunction are the four most commonly used configurations.…”

Section: Introductionmentioning

confidence: 99%

“…Droplets are widely used as micro-reaction chambers , and precursors for functional solid particles, − capsules, , and gels due to their advantages such as minimal consumption, a large specific surface area, and accurate dose control. Hydrogels, most of which are made with non-Newtonian droplets as precursors, can be used for wound dressing and drug release, such as sodium alginate (SA) and chitosan hydrogel. , However, conventional droplet preparation techniques often have disadvantages such as low monodispersity, poor controllability, and high energy consumption . Recently, microfluidics has become a promising technology with its advantages of high controllability, stability, and high packaging efficiency …”

Section: Introductionmentioning

confidence: 99%

Shear-Thinning Fluid Droplets Formation in Axisymmetric Flow-Focusing Microfluidics

Cao,

Lu,

et al. 2024

Ind. Eng. Chem. Res.

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The formation of shear-thinning fluid [sodium alginate (SA) solution] droplets in a continuous Newtonian fluid phase is studied numerically. The influences of shear thinning effects on the interface evolution, flow regimes, droplet size, and formation frequency are examined. A regime diagram is summarized in terms of the Capillary number of the continuous phase (Ca) and the concentration of the shear-thinning fluid (c nN-f , the concentration of the SA solution). The results show that the regime transition from dripping to jetting caused by increasing Ca is delayed when the dispersed phase is a shear-thinning fluid, which is advantageous in the production of highly monodispersed droplets. Additionally, c nN-f shows a distinct influence on dripping and jetting regimes. In dripping regimes, increasing c nN-f results in decreased droplet size with a high formation frequency. This study provides a theoretical reference for the preparation of shearthinning fluid droplets and is also helpful in clarifying the formation mechanism of non-Newtonian droplets.

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An integrative method to increase the reliability of conventional double emulsion method

Cited by 8 publications

References 73 publications

Polymer Microspheres and Their Application in Cancer Diagnosis and Treatment

Polymer Microspheres and Their Application in Cancer Diagnosis and Treatment

Application of Biomedical Microspheres in Wound Healing

Shear-Thinning Fluid Droplets Formation in Axisymmetric Flow-Focusing Microfluidics

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