An integrative approach of linking traditional Chinese medicine pattern classification and biomedicine diagnosis

Lü, Aiping; Jiang, Miao; Zhang, Chi; Chan, Kelvin

doi:10.1016/j.jep.2011.08.045

Cited by 133 publications

(87 citation statements)

References 47 publications

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“…Thus, all ICH patients can be treated with PBCRBS therapy. However, the syndrome summarizes the nature, location, and syndrome of diseases, which is traditionally identified from a comprehensive analysis of clinical information from four main diagnostic TCM methods: observation, listening, questioning, and pulse analyses [58] . Whether modern blood stasis is different from traditional blood stasis and whether their correlation with prescriptions corresponds to the syndrome requires further clarification; this may contribute to not only the essence of the blood stasis syndrome but also evidence-based syndrome identification in ICH.…”

Section: Implications For Further Researchmentioning

confidence: 99%

Promoting blood circulation for removing blood stasis therapy for acute intracerebral hemorrhage: a systematic review and meta-analysis

Wei

Wan

et al. 2015

Acta Pharmacol Sin

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Aim: To conduct a systematic review and meta-analysis to assess the current evidence available regarding the promoting blood circulation and removing blood stasis (PBCRBS) therapy for Chinese patients with acute intracerebral hemorrhage (ICH). Methods: Six databases were searched from their inception to November 2013. The studies assessed in ≥4 domains with 'yes' were selected for detailed assessment and meta-analysis. The herbal compositions for PBCRBS therapy for acute ICH patients were also assessed.Results: From the 6 databases, 292 studies claimed randomized-controlled clinical trials (RCTs). Nine studies with 798 individuals were assessed in ≥4 domains with 'yes' by using the Cochrane RoB tool. Meta-analysis showed that PBCRBS monotherapy and adjuvant therapy for acute ICH could improve the neurological function deficit, reduce the volume of hematoma and perihematomal edema, and lower the mortality rate and dependency. Moreover, there were fewer adverse effects when compared with Western conventional medication controls. Xueshuantong Injection and Fufang Danshen Injection, Buyang Huanwu Decoction and Liangxue Tongyu formula, and three herbs (danshen root, sanqi and leech) were the most commonly used Chinese herbal patent injections, herbal prescriptions and single herbs, respectively. Conclusion: Despite the apparently positive findings, it is premature to conclude that there is sufficient efficacy and safety of PBCRBS for ICH because of the high clinical heterogeneity of the included studies and small number of trials in the meta-analysis. Further large sample-sizes and rigorously designed RCTs are needed.

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Section: Implications For Further Researchmentioning

confidence: 99%

Promoting blood circulation for removing blood stasis therapy for acute intracerebral hemorrhage: a systematic review and meta-analysis

Wei

Wan

et al. 2015

Acta Pharmacol Sin

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“…We would certainly be speaking about molecular (proteins) differences between temperaments after a complete fractionation and mass spectrometry analysis, that is important for the identification of biomarkers of these temperaments and is necessary to explain the mechanism of these differences [11,24]. Further investigation by means of other high-throughput bio-techniques, such as genomics and metabolomics, and comparison of other temperaments (fig.…”

Section: Resultsmentioning

confidence: 99%

Proteomics and Traditional Medicine: New Aspect in Explanation of Temperaments

et al. 2014

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“…However, recently there have been attempts to search for common grounds and build scientifically viable leads for the integration (Kang, 2008;van der Greef et al, 2010;Lu et al, 2011). It is expected that combining several ongoing scientific and clinical developments in the study of CHM would offer a common ground for integration.…”

Section: Discussionmentioning

confidence: 99%

Omics and its potential impact on R&D and regulation of complex herbal products

Pelkonen

Pasanen

Lindon

et al. 2012

Journal of Ethnopharmacology

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In traditional Chinese medicine (TCM), multicomponent and principally plant-derived drugs are used for disease prevention, symptom amelioration and treatment in a personalized manner. Because of their complex composition and consequent multiple targets and treatment objectives, the application of omics techniques and other integrative approaches seems inherently appropriate and even necessary for the demonstration of their potential preclinical and clinical safety and efficacy. This perspectives article provides proposals for the application of omics methods to the investigation of complex herbal products (CHP),(1) including Chinese herbal medicines (CHM), both in vitro and in vivo, for preclinical and clinical toxicity, pharmacokinetics, pharmacodynamics and efficacy tests. Ultimately, such approaches could aid regulatory scrutiny and potential acceptance, although currently there is no regulatory requirement of omics-based data in any submitted dossier to any regulatory agency, including for conventional drugs and CHP. However, it has been acknowledged that such studies are being increasingly performed, and almost surely will eventually be included into regulatory submission dossiers, possibly initially as supplementary materials. Specifically for CHM and CHP, omics can play a role both in determining product composition and its variability and in monitoring biological effects in carefully selected platforms. Predicting the future is difficult, but it seems possible that regulatory acceptance of omics techniques and a systems biology approach for the study of TCM, CHM and CHP will not be long delayed. It is expected that current studies and plans employing omics techniques and other integrative approaches will prove to be positive and informative.

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An integrative approach of linking traditional Chinese medicine pattern classification and biomedicine diagnosis

Cited by 133 publications

References 47 publications

Promoting blood circulation for removing blood stasis therapy for acute intracerebral hemorrhage: a systematic review and meta-analysis

Promoting blood circulation for removing blood stasis therapy for acute intracerebral hemorrhage: a systematic review and meta-analysis

Proteomics and Traditional Medicine: New Aspect in Explanation of Temperaments

Omics and its potential impact on R&D and regulation of complex herbal products

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