An integrated targeting drug delivery system based on the hybridization of graphdiyne and MOFs for visualized cancer therapy

Xue, Zhongbo; Zhu, Mengyao; Dong, Yuze; Feng, Tong; Chen, Zhuozhi; Feng, Yaqing; Shan, Zhongqiang; Xu, Jialiang; Meng, Shuxian

doi:10.1039/c9nr02017a

Cited by 85 publications

(34 citation statements)

References 61 publications

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“…The π-π stacks generated between the aromatic structure of Dpphen or Phen ligand and nucleobases, as well as the anionic DNA backbone to form an electrostatic attraction with the positively charged ligands (NMe 3+ ) and metals ions (In 3+ ) ( Li et al, 2016 ). Other ionized MOFs including the carboxyl-rich MOF-n family ( Yaghi et al, 1995 ), IRMOF-n family ( Eddaoudi et al, 2002 ), MIL-n family ( Dan Hardi et al, 2009 ; Naeimi and Faghihian, 2019 ), UiO-n ( Cavka et al, 2008 ; Gupta et al, 2019 ), DUT-n ( Abazari et al, 2018 ; Grunker et al, 2014 ), and imidazole-rich ZIF-n family ( Park et al, 2006 ; Sheno et al, 2019 ; Zhao et al, 2019b ), or functional groups in the ligand, such as pyridine group (-C 5 H 4 N) ( Lago et al, 2016 ), imidazolyl (-C 3 H 3 N 2 ) ( Zhao et al, 2019b ), carboxyl group (-COOH) ( Adhikari et al, 2018 ), daunosamine and amino group (-NH 2 ) ( Nezhad-Mokhtari et al, 2019 ; Xue et al, 2019 ), phenolic hydroxyl group ( Ke et al, 2019 ), might also have great potential to be adopted as a source of electrostatic interaction for nucleic acid detection owing to the protonated ligand and the charge reverses in an acidic environment. Besides, designing charged MOF is an excellent idea ( Zhao et al, 2019c ) in addition to introducing functional groups ( Ali Akbar Razavi and Morsali, 2019 ).…”

Section: Viral Nucleic Acid Detection Based On Mofmentioning

confidence: 99%

Metal-organic frameworks for virus detection

Wang

et al. 2020

Biosensors and Bioelectronics

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Virus severely endangers human life and health, and the detection of viruses is essential for the prevention and treatment of associated diseases. Metal-organic framework (MOF), a novel hybrid porous material which is bridged by the metal clusters and organic linkers, has become a promising biosensor platform for virus detection due to its outstanding properties including high surface area, adjustable pore size, easy modification, etc. However, the MOF-based sensing platforms for virus detection are rarely summarized. This review systematically divided the detection platforms into nucleic acid and immunological (antigen and antibody) detection, and the underlying sensing mechanisms were interpreted. The nucleic acid sensing was discussed based on the properties of MOF (such as metal ion, functional group, geometry structure, size, porosity, stability, etc.), revealing the relationship between the sensing performance and properties of MOF. Moreover, antibodies sensing based on the fluorescence detection and antigens sensing based on molecular imprinting or electrochemical immunoassay were highlighted. Furthermore, the remaining challenges and future development of MOF for virus detection were further discussed and proposed. This review will provide valuable references for the construction of sophisticated sensing platform for the detection of viruses, especially the 2019 coronavirus.

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Section: Viral Nucleic Acid Detection Based On Mofmentioning

confidence: 99%

Metal-organic frameworks for virus detection

Wang

et al. 2020

Biosensors and Bioelectronics

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“…The above experiments provide possibilities for the application of magnetic-field-responsive MOF. A composite material of graphdiyne and MOFs, Fe 3 O 4 @UIO-66-NH 2 /graphdiyne (FUGY), with superior ability for magnetic targeting, was designed and synthesized by Xue's team [76]. This integrated nanosystem releases more drugs at the tumor site.…”

Section: Magnetic-field-responsive Metal Organic Framework-based Tarmentioning

confidence: 99%

Metal Organic Frameworks as Drug Targeting Delivery Vehicles in the Treatment of Cancer

et al. 2020

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In recent years, metal organic frameworks (MOFs) have been widely developed as vehicles for the effective delivery of drugs to tumor tissues. Due to the high loading capacity and excellent biocompatibility of MOFs, they provide an unprecedented opportunity for the treatment of cancer. However, drugs which are commonly used to treat cancer often cause side effects in normal tissue accumulation. Therefore, the strategy of drug targeting delivery based on MOFs has excellent research significance. Here, we introduce several intelligent targeted drug delivery systems based on MOFs and their characteristics as drug-loading systems, and the challenges of MOFs are discussed. This article covers the following types of MOFs: Isoreticular Metal Organic Frameworks (IRMOFs), Materials of Institute Lavoisier (MILs), Zeolitic Imidazolate Frameworks (ZIFs), University of Oslo (UiOs), and MOFs-based core-shell structures. Generally, MOFs can be reasonably controlled at the nanometer size to effectively achieve passive targeting. In addition, different ligands can be modified on MOFs for active or physicochemical targeting. On the one hand, the targeting strategy can improve the concentration of the drugs at the tumor site to improve the efficacy, on the other hand, it can avoid the release of the drugs in normal tissues to improve safety. Despite the challenges of clinical application of MOFs, MOFs have a number of advantages as a kind of smart delivery vehicle, which offer possibilities for clinical applications.

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“…Similar to graphene, in the infinite planar extension, the single-layer 2D planar configuration of GDY will form certain folds in order to maintain the stability of the configuration (Figure 1b) [31]. Due to its unique conjugated electronic structure [32], extraordinary conductivity and adjustable electronic characteristics [33,34], GDY with controllable full-carbon framework of atomic thickness has been applied in the field of electrocatalysis [35][36][37][38][39]. In the structure of GDY, adjacent benzene rings (sp 2 -hybridized carbon) linked to each other through butadiyne linkages (sp-hybridized carbon) [40].…”

Section: Introductionmentioning

confidence: 99%

Atomic-Level Functionalized Graphdiyne for Electrocatalysis Applications

et al. 2020

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Graphdiyne (GDY) is a two-dimensional (2D) electron-rich full-carbon planar material composed of sp2- and sp-hybridized carbon atoms, which features highly conjugated structures, uniformly distributed pores, tunable electronic characteristics and high specific surface areas. The synthesis strategy of GDY by facile coupling reactions under mild conditions provides more convenience for the functional modification of GDY and offers opportunities for realizing the special preparation of GDY according to the desired structure and unique properties. These structural characteristics and excellent physical and chemical properties of GDY have attracted increasing attention in the field of electrocatalysis. Herein, the research progress in the synthesis of atomic-level functionalized GDYs and their electrocatalytic applications are summarized. Special attention was paid to the research progress of metal-atom-anchored and nonmetallic-atom-doped GDYs for applications in the oxygen reduction reaction (ORR), the oxygen evolution reaction (OER) and the hydrogen evolution reaction (HER) catalytic processes. In addition, several potential development prospects and challenges of these 2D highly conjugated electron-rich full-carbon materials in the field of electrocatalysis are presented.

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An integrated targeting drug delivery system based on the hybridization of graphdiyne and MOFs for visualized cancer therapy

Abstract: Graphdiyne and UIO-66-NH2 form a framework structure as a drug carrier and apply to tumor therapy.

Cited by 85 publications

References 61 publications

Metal-organic frameworks for virus detection

Metal-organic frameworks for virus detection

Metal Organic Frameworks as Drug Targeting Delivery Vehicles in the Treatment of Cancer

Atomic-Level Functionalized Graphdiyne for Electrocatalysis Applications

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