An integrated QCM-based narcotics sensing microsystem

Frisk, Thomas; Sandström, Niklas; Eng, L.E.; Wijngaart, Wouter van der; Månsson, Per; Stemme, G.

doi:10.1039/b800487k

Cited by 18 publications

(11 citation statements)

References 20 publications

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“…c Front and backside pictures of two devices. The QCM crystal is visible through the polymer backside cover (Source: Frisk et al 2008) quantification of the detection, such as reaction accompanied by gas production. SPR detection method is growing rapidly, mostly because it is a free labelng and real-time response detection method, and the background noise is virtually eliminated.…”

Section: Discussionmentioning

confidence: 99%

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Microfluidic whole-blood immunoassays

Jiang

Weng

2010

Microfluid Nanofluid

100

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Immunoassay is one of the most widely used biomedical diagnostic methods due to its sensitivity and specificity. Microfluidic lab-on-a-chip technology has the advantages of portability, integration, and automation. The combination of these two technologies leads to a pathway for point-of-care diagnostics using the unprocessed samples such as the whole blood. This article reviews the recent advancement and the major development in the microfluidic-based whole-blood immunoassays. After a survey of the recent studies on microfluidic whole-blood immunoassays, an in-depth review about the detection methods that can be miniaturized and integrated in the immunoassay chips is provided. Point-of-care diagnostics applications require developing a fully integrated, disposable, low-cost, and handheld microfluidic device for the whole-blood immunoassay. In this regard, some comments and suggestions for future research are given.

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Section: Discussionmentioning

confidence: 99%

“…The detection limit for protein A is 1 mg/mL. Recently, Frisk et al (2008) reported a novel microsystem which absorbed airborne narcotics molecules and performed a liquid assay using an integrated quartz crystal microbalance (QCM). In this study, the microsystem consisted of four parts.…”

Section: Quartz Crystal Microbalancementioning

confidence: 99%

Microfluidic whole-blood immunoassays

Jiang

Weng

2010

Microfluid Nanofluid

100

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“…Airborn narcotics detected using an integrated quartz crystal microbalance and a liquid assay have been reported by Frisk et al (92). Portability is an important feature for a microfluidic system.…”

Section: Technologymentioning

confidence: 96%

Latest Developments in Micro Total Analysis Systems

et al. 2010

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The field of micro total analysis systems (µTAS) (1) or lab on a chip (LOC) has extended its usefulness into many new fields and disciplines spanning basic research to commercial applications. The importance of µTAS is reflected in both the growing number and improved quality of published articles. µTAS has expanded into an incredibly diverse number of analytical chemistry applications and has received a great amount of input from a wide spectrum of scientific and engineering disciplines. In this sense, µTAS is highly interdisciplinary and has served as a focal point to bring together multidisciplinary research fields.This work builds on former reviews (2-6) and attempts to chart the most recent developments in µTAS. By cross referencing online keyword searches, several thousand articles were found spread among a wide variety of journals but were most frequently found in the high impact journals such as Science, Nature, PNAS, Analytical Chemistry, Lab on a Chip, and others. The annual international µTAS conference also provided articles on some of the very latest and most promising developments. This review article aims to report the latest achievements in the field of µTAS by highlighting some of the very best research papers published over the 2 year period between March 2008 and February 2010. Our main goal is to give a broad overview of the latest state-ofthe-art research and to introduce newcomers to the field. We were overwhelmed by the large number of research papers published on cellular analysis, manipulation, and droplet fluidics; therefore, we divided the review into two parts. This first part concentrates on reports related to manufacturing, technology, and instrumentation for molecular analysis, and part two covers applications related to cellular analysis and manipulation, which is referred to as cellson-a-chip (460). The papers we selected on droplet fluidics are distributed throughout both parts of the article according to their applications. We attempted to select papers based on the merit of their contents, which was a difficult task, and we have missed some good articles; for these oversights, we offer our apology in advance.Since this review focuses on novel developments of microfluidic systems for applied analytical chemical applications, publications about sensor arrays (so-called "biochips"), chemical synthesis on microchips (except some papers on particle synthesis using droplets), theory, and simulations, as well as trend articles, have been omitted. Furthermore, we reduced the technology section, as the majority of work is carried out by employing simple planar microchips fabricated in glass or polymers such as silicone elastomers. TECHNOLOGYMicrofabrication. Conventional Microfabrication. Many new innovative approaches have been reported in the field of microfabrication. Semicircular cross section channels network microfabricated on a silicon chip by XeF 2 etching by Camp et al. (7). These channels allow stress free transportation of cells. Generally, vapor deposited thin film metal ele...

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“…In particular, a robust air-liquid interface is required to allow capture of the aerosol droplets and dispersion of the captured sample in a liquid medium, in which direct initiation of specific ligand-receptor biochemical reactions can occur. We have previously presented microsystem-based components for air-liquid interfacing in combination with downstream analysis, for quartz crystal microbalance (QCM) sensing of airborne narcotics [44,45]. Two examples of such surface tension-based air-liquid interfacing include: pillar forests and perforated diaphragms.…”

Section: Introductionmentioning

confidence: 99%

Aerosol sampling using an electrostatic precipitator integrated with a microfluidic interface

Pardon

Ladhani

Sandström

et al. 2015

Sensors and Actuators B: Chemical

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PostprintThis is the accepted version of a paper published in Sensors and actuators. B, Chemical. This paper has been peer-reviewed but does not include the final publisher proof-corrections or journal pagination.Citation for the original published paper (version of record):Pardon, G., Ladhani, L., Sandström, N., Ettori, M., Lobov, G. et al. [Year unknown!] Aerosol sampling using an electrostatic precipitator integrated with a microfluidic interface. Sensors and actuators. B, Chemical AbstractIn this work, the development of a point-of-care (PoC) system to capture aerosol from litres of air directly onto a microfluidic lab-on-chip for subsequent analysis is addressed. The system involves an electrostatic precipitator that uses corona charging and electrophoretic transport to capture aerosol droplets onto a microfluidic air-to-liquid interface for downstream analysis. A theoretical study of the governing geometric and operational parameters for optimal electrostatic precipitation is presented. The fabrication of an electrostatic precipitator prototype and its experimental validation using a laboratory-generated aerosolized dye is described. Collection efficiencies were comparable to those of a state-of-the-art Biosampler impinger, with the significant advantage of providing samples that are at least 10 times more concentrated. Finally, we discuss the potential of such a system for breath-based diagnostics.

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An integrated QCM-based narcotics sensing microsystem

Cited by 18 publications

References 20 publications

Microfluidic whole-blood immunoassays

Microfluidic whole-blood immunoassays

Latest Developments in Micro Total Analysis Systems

Aerosol sampling using an electrostatic precipitator integrated with a microfluidic interface

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