“…For the integrated analysis, we included 15 datasets comprising 429 iPSMNs, of which 323 were from ALS patients and 106 were from non-ALS controls. ALS iPSMNs carried pathogenic mutations in 10 different genes, including C9orf72 22,23,[25][26][27][28] (n = 60), SOD1 18,19,[21][22][23] (n = 20), FUS 20,23,25,29,30 (n = 14), and TARDBP 23,26,31,32 (n = 10); whilst 208 (64.2%) were from patients without an identifiable ALS mutation, which we refer to here as sporadic ALS (Table 1).…”