A systems-biology approach connects aging mechanisms with Alzheimer’s disease pathogenesis
Matthew J Leventhal,
Camila A Zanella,
Byunguk Kang
et al.
Abstract:Age is the strongest risk factor for developing Alzheimer's disease, the most common neurodegenerative disorder. However, the mechanisms connecting advancing age to neurodegeneration in Alzheimer's disease are incompletely understood. We conducted an unbiased, genome-scale, forward genetic screen for age-associated neurodegeneration in Drosophila to identify the underlying biological processes required for maintenance of aging neurons. To connect genetic screen hits to Alzheimer's disease pathways, we measured… Show more
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