An integrated microfluidic platform for magnetic microbeads separation and confinement

Ramadan, Qasem; Samper, Victor; Poenar, Daniel Puiu; Chen, Yu

doi:10.1016/j.bios.2005.08.006

Cited by 76 publications

(43 citation statements)

References 9 publications

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“…Photolithographic techniques enable fabrication of almost any desired MET geometry; as a result the geometry of an MET can be tuned for a specific application. Ramadan et al [18,[21][22][23][24][25][26][27] and Lee et al [20,28] have demonstrated customized MP traps which emphasize the effects of different MET geometries. Simulations of magnetic fields produced by different MET geometries have magnetic field profiles attributed to the shape of the MET and magnetic coupling between conductors or loops.…”

Section: Geometrymentioning

confidence: 94%

Applications of microelectromagnetic traps

Basore

Baker

2012

Anal Bioanal Chem

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Microelectromagnetic traps (METs) have been used for almost two decades to manipulate magnetic fields. Different trap geometries have been shown to produce distinct magnetic fields and field gradients. Initially, microelectromagnetic traps were used mainly to separate and concentrate magnetic material at small scales. Recently such traps have been implemented for unique applications, for example filterless bioseparations, inductive heat generation, and biological detection. In this review, we describe recent reports in which MET geometry, current density, or external fields have been used. Descriptions of recent applications in which METs have been used to develop sensors, manipulate DNA, or block ion current are also provided.

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Section: Geometrymentioning

confidence: 94%

Applications of microelectromagnetic traps

Basore

Baker

2012

Anal Bioanal Chem

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“…If the external magnetic field is large enough to magnetically saturate the superparamagnetic magnetic bead, then maximizing the force is equivalent to maximizing the magnetic field gradient. If we neglect the magnetic property of the suspension medium, the force acting on a magnetic bead is given as follows [14][15][16].…”

Section: Theoretical Background For Magneticmentioning

confidence: 99%

Programmable Magnetic Actuation of Biomolecule Carriers using NiFe Stepping Stones

Lim¹,

Jeong²,

Kim³

et al. 2011

Journal of Magnetics

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We have designed, fabricated and demonstrated a novel micro-system for programmable magnetic actuation using magnetic elliptical pathways on Si substrates. Lithographically patterned soft NiFe ellipses are arranged sequentially perpendicular to each other as stepping stones for the transport of magnetic beads. We have measured the magnetization curve of the ellipsoid (9 µm × 4 µm × 0.1 µm) elements with respect to the long and short axes of the ellipse. We found that the magnetization in the long axis direction is larger than that in the short axis direction for an applied field of ≤ 1,000 Oe, causing a force on carriers that causes them to move from one element to another. We have successfully demonstrated a micro-system for the magnetic actuation of biomolecule carriers of superparamagnetic beads (Dynabead ® 2.8 µm) by rotating the external magnetic field. This novel concept of magnetic actuation is useful for future integrated lab-on-a-chip systems for biomolecule manipulation, separation and analysis.

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“…An emerging class of applications that make use of magnetic nano-objects is the identification of biological species in Micro Total Analysis Systems ( TAS) [1] or separation devices [2], [3]. A typical application of magnetic separation in a lab-on-a-chip system consists of a microfluidic channel provided with one or more magnetic elements at the bottom wall [4]- [6]. Magnetic micro-or nano-objects coated with specific biomolecules are then flowed through the micro-channel and confined in the regions of high field-gradient generated by the magnetic elements.…”

mentioning

confidence: 99%

“…Magnetic micro-or nano-objects coated with specific biomolecules are then flowed through the micro-channel and confined in the regions of high field-gradient generated by the magnetic elements. The efficiency of this process is dependent not only on the degree of selectivity with which the chemical or biological targets can be attached to the magnetic carriers but also by the efficiency of the magnetic manipulation and capture [5], [6]. While the selectivity and the specificity to the targets is related to the surface functionalization and can be solved by the right choice of the chemical or linker attached to the carrier surface, the efficiency of the magnetic manipulation relies upon the design of both confinement device and magnetic carriers.…”

mentioning

confidence: 99%