An Integrated Circuit for Simultaneous Extracellular Electrophysiology Recording and Optogenetic Neural Manipulation

Chen, Chang Hao; McCullagh, Elizabeth A.; Pun, Sio Hang; Mak, Peng Un; Vai, Mang I; Mak, Pui In; Klug, Achim; Lei, Tim C.

doi:10.1109/tbme.2016.2609412

Cited by 35 publications

(23 citation statements)

References 72 publications

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“…A reconfigurable silicon neural processor for real-time simulation and prediction of opto-neural behavior and an integrated circuit for simultaneous extracellular electrophysiology recording and optogenetic neural manipulation have also been recently reported. 37,38 The theoretical analysis presented here would also be, in general, useful to develop such hardware for optogenetic applications.…”

Section: (C) and 5(d) A Comparison Of Photocurrents Ofmentioning

confidence: 99%

Theoretical analysis of low-power fast optogenetic control of firing of Chronos-expressing neurons

2018

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A detailed theoretical analysis of low-power, fast optogenetic control of firing of Chronos-expressing neurons has been presented. A three-state model for the Chronos photocycle has been formulated and incorporated in a fast-spiking interneuron circuit model. The effect of excitation wavelength, pulse irradiance, pulse width, and pulse frequency has been studied in detail and compared with ChR2. Theoretical simulations are in excellent agreement with recently reported experimental results and bring out additional interesting features. At very low irradiances ([Formula: see text]), the plateau current in Chronos exhibits a maximum. At [Formula: see text], the plateau current is 2 orders of magnitude smaller and saturates at longer pulse widths ([Formula: see text]) compared to ChR2 ([Formula: see text]). [Formula: see text] in Chronos saturates at much shorter pulse widths (1775 pA at 1.5 ms and [Formula: see text]) than in ChR2. Spiking fidelity is also higher at lower irradiances and longer pulse widths compared to ChR2. Chronos exhibits an average maximal driven rate of over [Formula: see text] in response to [Formula: see text] stimuli, each of 1-ms pulse-width, in the intensity range 0 to [Formula: see text]. The analysis is important to not only understand the photodynamics of Chronos and Chronos-expressing neurons but also to design opsins with optimized properties and perform precision experiments with required spatiotemporal resolution.

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Section: (C) and 5(d) A Comparison Of Photocurrents Ofmentioning

confidence: 99%

Theoretical analysis of low-power fast optogenetic control of firing of Chronos-expressing neurons

2018

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“…Stimulation and sensing can be implemented exclusively with optical elements (Inagaki et al, 2017 ). A combination of techniques, such as electrophysiology and optogenetics (Chen et al, 2017 ) or micro-fluidics (Rubehn et al, 2013 ; McCall et al, 2017 ), can offer additional perspectives in feedback controlled systems.…”

Section: Implanted Optical Brain Stimulatormentioning

confidence: 99%

And Then There Was Light: Perspectives of Optogenetics for Deep Brain Stimulation and Neuromodulation

et al. 2017

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Deep Brain Stimulation (DBS) has evolved into a well-accepted add-on treatment for patients with severe Parkinsons disease as well as for other chronic neurological conditions. The focal action of electrical stimulation can yield better responses and it exposes the patient to fewer side effects compared to pharmaceuticals distributed throughout the body toward the brain. On the other hand, the current practice of DBS is hampered by the relatively coarse level of neuromodulation achieved. Optogenetics, in contrast, offers the perspective of much more selective actions on the various physiological structures, provided that the stimulated cells are rendered sensitive to the action of light. Optogenetics has experienced tremendous progress since its first in vivo applications about 10 years ago. Recent advancements of viral vector technology for gene transfer substantially reduce vector-associated cytotoxicity and immune responses. This brings about the possibility to transfer this technology into the clinic as a possible alternative to DBS and neuromodulation. New paths could be opened toward a rich panel of clinical applications. Some technical issues still limit the long term use in humans but realistic perspectives quickly emerge. Despite a rapid accumulation of observations about patho-physiological mechanisms, it is still mostly serendipity and empiric adjustments that dictate clinical practice while more efficient logically designed interventions remain rather exceptional. Interestingly, it is also very much the neuro technology developed around optogenetics that offers the most promising tools to fill in the existing knowledge gaps about brain function in health and disease. The present review examines Parkinson's disease and refractory epilepsy as use cases for possible optogenetic stimulation therapies.

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“…Our interest in this work is therefore to develop an electronic control system, which can both drive high radiance µLEDs and perform electronic recording. To date, there is only one other example of this in the literature [23]. In that work, the stimulator circuitry is designed primarily for laser control, and the electronic recording is designed for single unit (action potential) recordings.…”

Section: Introductionmentioning

confidence: 99%

On-Probe Neural Interface ASIC for Combined Electrical Recording and Optogenetic Stimulation

Ramezani

Liu

Dehkhoda

et al. 2018

IEEE Trans. Biomed. Circuits Syst.

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Neuromodulation technologies are progressing from pacemaking and sensory operations to full closed-loop control. In particular, optogenetics-the genetic modification of light sensitivity into neural tissue allows for simultaneous optical stimulation and electronic recording. This paper presents a neural interface application-specified integrated circuit (ASIC) for intelligent optoelectronic probes. The architecture is designed to enable simultaneous optical neural stimulation and electronic recording. It provides four low noise (2.08 μV) recording channels optimized for recording local field potentials (LFPs) (0.1-300 Hz bandwidth, 5 mV range, sampled 10-bit@4 kHz), which are more stable for chronic applications. For stimulation, it provides six independently addressable optical driver circuits, which can provide both intensity (8-bit resolution across a 1.1 mA range) and pulse-width modulation for high-radiance light emitting diodes (LEDs). The system includes a fully digital interface using a serial peripheral interface (SPI) protocol to allow for use with embedded controllers. The SPI interface is embedded within a finite state machine (FSM), which implements a command interpreter that can send out LFP data whilst receiving instructions to control LED emission. The circuit has been implemented in a commercially available 0.35 μm CMOS technology occupying a 1.95 mm 1.10 mm footprint for mounting onto the head of a silicon probe. Measured results are given for a variety of bench-top, in vitro and in vivo experiments, quantifying system performance and also demonstrating concurrent recording and stimulation within relevant experimental models.

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An Integrated Circuit for Simultaneous Extracellular Electrophysiology Recording and Optogenetic Neural Manipulation

Cited by 35 publications

References 72 publications

Theoretical analysis of low-power fast optogenetic control of firing of Chronos-expressing neurons

Theoretical analysis of low-power fast optogenetic control of firing of Chronos-expressing neurons

And Then There Was Light: Perspectives of Optogenetics for Deep Brain Stimulation and Neuromodulation

On-Probe Neural Interface ASIC for Combined Electrical Recording and Optogenetic Stimulation

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