An integrated and conductive hydrogel-paper patch for simultaneous sensing of Chemical–Electrophysiological signals

Li, Tianyu; Liang, Bo; Ye, Zhichao; Zhang, Lei; Xu, Shiyi; Tu, Tingting; Zhang, Yiming; Cai, Yu; Zhang, Bin; Lü, Fang; Mao, Xiaole; Zhang, Shanshan; Wu, Guan; Yang, Qinghui; Zhou, Congcong; Cai, Xiujun; Ye, Xuesong

doi:10.1016/j.bios.2021.113855

Cited by 66 publications

(63 citation statements)

References 51 publications

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“…Recently, a few studies have also used the combination of a hydrogel and paper channel for sweat sensing. 63,64 However, these patches have not been used to measure sweat lactate from skin; the hydrogel has been used to sample sweat separately and then place it on a sensor for detecting biomarkers at rest; 63 this functions only under active exercise with low sensing durations and functions with conventional electronics. 64 The lactate in the withdrawn sweat sample is then sensed on the circular section of the paper microfluidic channel, where it creates an electrochemical cell across the working, counter, and RE on the PI sheet (ELS, Figure 1D).…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…The hydrogel withdraws a sweat sample due to its higher osmotic strength with respect to the sweat inside the skin. Recently, a few studies have also used the combination of a hydrogel and paper channel for sweat sensing. , However, these patches have not been used to measure sweat lactate from skin; the hydrogel has been used to sample sweat separately and then place it on a sensor for detecting biomarkers at rest; this functions only under active exercise with low sensing durations and functions with conventional electronics …”

Section: Resultsmentioning

confidence: 99%

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Wireless Wearable Electrochemical Sensing Platform with Zero-Power Osmotic Sweat Extraction for Continuous Lactate Monitoring

et al. 2022

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Wearable and wireless monitoring of biomarkers such as lactate in sweat can provide a deeper understanding of a subject's metabolic stressors, cardiovascular health, and physiological response to exercise. However, the state-of-the-art wearable and wireless electrochemical systems rely on active sweat released either via high-exertion exercise, electrical stimulation (such as iontophoresis requiring electrical power), or chemical stimulation (such as by delivering pilocarpine or carbachol inside skin), to extract sweat under lowperspiring conditions such as at rest. Here, we present a continuous sweat lactate monitoring platform combining a hydrogel for osmotic sweat extraction, with a paper microfluidic channel for facilitating sweat transport and management, a screen-printed electrochemical lactate sensor, and a custom-built wireless wearable potentiostat system. Osmosis enables zeroelectrical power sweat extraction at rest, while continuous evaporation at the end of a paper channel allows long-term sensing from fresh sweat. The positioning of the lactate sensors provides near-instantaneous sensing at low sweat volume, and the custom-designed potentiostat supports continuous monitoring with ultra-low power consumption. For a proof of concept, the prototype system was evaluated for continuous measurement of sweat lactate across a range of physiological activities with changing lactate concentrations and sweat rates: for 2 h at the resting state, 1 h during mediumintensity exercise, and 30 min during high-intensity exercise. Overall, this wearable system holds the potential of providing comprehensive and long-term continuous analysis of sweat lactate trends in the human body during rest and under exercising conditions.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Wireless Wearable Electrochemical Sensing Platform with Zero-Power Osmotic Sweat Extraction for Continuous Lactate Monitoring

et al. 2022

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“…Beside the strain sensors, 3D printed conductive hydrogels have also been widely applied in detecting temperature, 9 humidity, 130 gas, 131 chemical substances 132 and optics. 133 However, more research studies are expected to further improve the performance of the sensors, and simplify the manufacturing process as well.…”

Section: Sensorsmentioning

confidence: 99%

Recent advances in the 3D printing of electrically conductive hydrogels for flexible electronics

et al. 2022

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“…[1][2][3][4][5][6] The enduring stability of long-term ambulatory electrophysiological sensing opens a sensory window to capture multidimensional physiological parameters related to human health. [7][8][9][10] It offers great potential in the fields of smart e-healthcare monitoring, [11][12][13][14] clinical diagnosis of cardiovascular diseases, [15][16][17][18] treatment of neurological diseases, [19][20][21] and intelligent human-machine interaction. [22][23][24][25][26] As the signal interaction bridge of ambulatory electrophysiological sensing, on-skin electrodes are conformally pasted on curved human-skin to perceive and analyze electrophysiological signals in a noninvasive manner.…”

Section: Introductionmentioning

confidence: 99%

Highly Conformal Polymers for Ambulatory Electrophysiological Sensing

Zhang

Liu

et al. 2022

Macromol. Rapid Commun.

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Stable ambulatory electrophysiological sensing is widely used for smart e-healthcare monitoring, clinical diagnosis of cardiovascular diseases, treatment of neurological diseases, and intelligent human-machine interaction. As the favorable signal interaction platform of electrophysiological sensing, the conformal property of on-skin electrodes is an extremely crucial factor that can affect the stability of long-term ambulatory electrophysiological sensing. From the perspective of materials, to realize conformal contact between electrodes and skin for stable sensing, highly conformal polymers are in great demand and attracting ever-growing attention. This review focuses on the recent progress of highly conformal polymers for ambulatory electrophysiological sensing, including their synthetic methods, conformal property, and potential applications. Specifically, three main types of highly conformal polymers for stable long-term electrophysiological signals monitoring are proposed, including nature silk fibroin based conformal polymers, marine mussels bioinspired conformal polymers, and other conformal polymers such as zwitterionic polymers and polyacrylamides. Furthermore, the future challenges and opportunities in preparing highly conformal polymers for on-skin electrodes are also highlighted.

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An integrated and conductive hydrogel-paper patch for simultaneous sensing of Chemical–Electrophysiological signals

Cited by 66 publications

References 51 publications

Wireless Wearable Electrochemical Sensing Platform with Zero-Power Osmotic Sweat Extraction for Continuous Lactate Monitoring

Wireless Wearable Electrochemical Sensing Platform with Zero-Power Osmotic Sweat Extraction for Continuous Lactate Monitoring

Recent advances in the 3D printing of electrically conductive hydrogels for flexible electronics

Highly Conformal Polymers for Ambulatory Electrophysiological Sensing

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