An inpatient lifestyle-change programme improves heart rate recovery in overweight and obese children and adolescents (LOGIC Trial)

Wilks, Désirée C.; Rank, Melanie; Christle, Jeffrey W.; Langhof, Helmut; Siegrist, Monika; Halle, Martin

doi:10.1177/2047487312465691

Cited by 10 publications

(11 citation statements)

References 28 publications

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“…Similar to our work, important decreases in heart rate, total cholesterol, LDL-cholesterol and triglycerides were achieved after short term interventions in obese children [11,12,40,41]. 13 However, we found no change in blood pressure, CNTF, leptin, and IL-6 serum levels in the HR group.…”

Section: Discussionsupporting

confidence: 88%

Decreased cardiotrophin-1 levels are associated with a lower risk of developing the metabolic syndrome in overweight/obese children after a weight loss program

et al. 2013

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Fax: 0034 948 425619Word count of text (3,301), abstract (250), number of references (50), number of tables (2) and number of figures (2). CONFLICT OF INTEREST:The authors have nothing to disclose. 2 ABSTRACTObjective: Cardiotrophin-1 (CT-1) shares some similarities with other cytokines, and participates in the control of energy metabolism. Higher circulating levels are observed in obese humans, but little information is gathered in weight loss (WL) programs.Therefore, we aimed to investigate the association of serum CT-1 levels with metabolic variables and the risk of developing metabolic syndrome (MetS) after a WL program in overweight/obese children. Subjects and Methods:Forty-four overweight/obese children (mean age 11.5 yr; 50% males) undergoing a 10-week WL program were enrolled. Subjects were dichotomized at the median of Body Mass Index-Standard Deviation Score (BMI-SDS) change, as high and low responders after intervention.Results: CT-1 levels were significantly reduced (-48 fmol/mL, p=0.043) in the high responder group after the WL program. They had significantly lower body weight (-3.7 kg, p<0.001), body fat mass (-8%, p<0.001), BMI-SDS (-0.78, p<0.001) and waist circumference (-5.4 cm, p<0.001), and a significant improvement in lipid and glucose profiles (p<0.05). Interestingly, decreased CT-1 levels significantly predicted changes in total cholesterol (41%) and LDL-cholesterol (28%). Moreover, in our participants the lower the CT-1 levels, the higher the reduction in MetS risk components, after the 10-week intervention, (p-ANCOVA=0.040, p-trend=0.024). Conclusion:We showed, for the first time, a reduction in serum CT-1 levels after a WL program and this decrease in CT-1 was strongly associated with a reduction in cholesterol levels and in MetS risk factors in overweight/obese children. Our findings may suggest that CT-1 could be an indirect marker for the diagnosis of MetS in this population.

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Section: Discussionsupporting

confidence: 88%

Decreased cardiotrophin-1 levels are associated with a lower risk of developing the metabolic syndrome in overweight/obese children after a weight loss program

et al. 2013

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“…Since the effect of obesity on ANS control of HRR can occur at an early age, lifestyle changes are important for the well-being of the children. In relation to this, inducing weight loss and introducing lifestyle programmes for overweight and obese children has been shown to improve their HRR [ 54 , 55 ] with the greatest improvement occurring in HRR 1 min [ 54 ]. This finding reiterates the importance of introducing a healthy lifestyle to the participants from a young age as it carries many positive effects of exercise and weight control on body composition measures as well as ANS of the heart.…”

Section: Discussionmentioning

confidence: 99%

The Correlates of Body Composition with Heart Rate Recovery after Step Test: An Exploratory Study of Malaysian Adolescents

et al. 2013

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BackgroundIn adults, heart rate recovery is a predictor of mortality, while in adolescents it is associated with cardio-metabolic risk factors. The aim of this study was to examine the relationship between body composition measures and heart rate recovery (HRR) after step test in Malaysian secondary school students.MethodsIn the Malaysian Health and Adolescents Longitudinal Research Team (MyHEART) study, 1071 healthy secondary school students, aged 13 years old, participated in the step test. Parameters for body composition measures were body mass index z-score, body fat percentage, waist circumference, and waist height ratio. The step test was conducted by using a modified Harvard step test. Heart rate recovery of 1 minute (HRR1min) and heart rate recovery of 2 minutes (HRR2min) were calculated by the difference between the peak pulse rate during exercise and the resting pulse rate at 1 and 2 minutes, respectively. Analysis was done separately based on gender. Pearson correlation analysis was used to determine the association between the HRR parameters with body composition measures, while multiple regression analysis was used to determine which body composition measures was the strongest predictor for HRR.ResultsFor both gender groups, all body composition measures were inversely correlated with HRR1min. In girls, all body composition measures were inversely correlated with HRR2min, while in boys all body composition measures, except BMI z-score, were associated with HRR2min. In multiple regression, only waist circumference was inversely associated with HRR2min (p=0.024) in boys, while in girls it was body fat percentage for HRR2min (p=0.008).ConclusionThere was an inverse association between body composition measurements and HRR among apparently healthy adolescents. Therefore, it is important to identify cardio-metabolic risk factors in adolescent as an early prevention of consequent adulthood morbidity. This reiterates the importance of healthy living which should start from young.

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“…28 Because subjects without clinically significant heart disease can exhibit exercise-induced hypotension, caused by delayed in the postexercise increase in systemic vascular resistance following prolonged high-intensity exercise, we chose an active recovery protocol similar to that in other studies. [29][30][31] Thus, in the recovery period, the first minute (50% of the maximum peak workload) and the second minute (25% of the maximum peak workload) were active with velocity at 60 rpm, whereas the third and fourth minutes were passive, with the patients still sitting on the bicycle.…”

Section: Cardiopulmonary Exercise Testmentioning

confidence: 99%

Obstructive Sleep Apnea Impairs Postexercise Sympathovagal Balance in Patients with Metabolic Syndrome

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Toschi‐Dias

Maki-Nunes

et al. 2015

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An inpatient lifestyle-change programme improves heart rate recovery in overweight and obese children and adolescents (LOGIC Trial)

Abstract: HRR considerably improved after an inpatient weight loss programme in overweight and obese children. This was not associated with improvements in body weight and cardio-metabolic risk; hence HRR would be a valuable addition to cardiovascular risk assessment in this group.

Cited by 10 publications

References 28 publications

Decreased cardiotrophin-1 levels are associated with a lower risk of developing the metabolic syndrome in overweight/obese children after a weight loss program

Decreased cardiotrophin-1 levels are associated with a lower risk of developing the metabolic syndrome in overweight/obese children after a weight loss program

The Correlates of Body Composition with Heart Rate Recovery after Step Test: An Exploratory Study of Malaysian Adolescents

Obstructive Sleep Apnea Impairs Postexercise Sympathovagal Balance in Patients with Metabolic Syndrome

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