An Inorganic Thymidine Helix:  Design of Homochiral Helical Arrays

Mitochondrial Mode of Action of a Thymidine‐Based Cisplatin Analogue Breaks Resistance in Cancer Cells

“…[18,19] The synthesis pathway applied is much more efficient than the introduction of two amino groups into uridine in the 2',3'-position or into dribose or 2-deoxy-d-ribose, [20,21] because the thymine residue acts as a protecting group of the 3'-position during the synthesis (see Scheme S1 in the Supporting Information). For the preparation of the platinum (3 and 5) and palladium complexes (4 and 6) an aqueous solution of potassium tetrachloroplatinate or potassium tetrachloropalladinate, respectively, was added dropwise into a boiling solution of the amine (1 or 2) in water (Scheme 1).…”

“…Synthesis and structural characterization of the complexes : The two 3′,5′‐diamino‐3′,5′‐dideoxy‐thymidines ( 1 and 2 ) were previously obtained as intermediates for the synthesis of metal complexes based on their condensation products with salicyliden aldehydes 18. 19 The synthesis pathway applied is much more efficient than the introduction of two amino groups into uridine in the 2′,3′‐position or into D ‐ribose or 2‐deoxy‐ D ‐ribose,20, 21 because the thymine residue acts as a protecting group of the 3′‐position during the synthesis (see Scheme S1 in the Supporting Information). For the preparation of the platinum ( 3 and 5 ) and palladium complexes ( 4 and 6 ) an aqueous solution of potassium tetrachloroplatinate or potassium tetrachloropalladinate, respectively, was added dropwise into a boiling solution of the amine ( 1 or 2 ) in water (Scheme ).…”

Nickel(II) complexes with Schiff-base ligands derived from epimeric pyranose backbones as 2,3-chelators: modeling the coordination chemistry of chitosan

“…doi:10.1016/j.carres.2008.01.039 were performed on the functionalization of the sugar backbone with amides, amines, imines, and carboxylic groups to accomplish a stronger metal-ion complexation. [14][15][16][17][18][19][20] The Schiff-base formation is especially explored concerning their common availability via condensation of amino sugars with aldehyde moieties. [21][22][23][24][25][26][27][28][29] Herein the syntheses and crystal structures of the mononuclear nickel(II) complexes with Schiff-base ligands derived from the epimeric sugars glucosamine ðH 2 sal NO 2 GlcÞ and mannosamine (H 2 sal H Man) are reported.…”

A novel 4·82 CdII network constructed from helical motif: Incorporating alternate left- and right-hand helical water chains

“…The most prominent examples of natural helices, probably, are the double-helical B-DNA and the a-helical structure found in proteins. Inspired by the enormous biological relevance of helical structures [1] and their potential applications in the fields of ion sensors, optical devices, and asymmetric catalysis [2], the design of artificial coordination polymeric materials exhibiting helical structures has been attracting increased attention in coordination chemistry and material chemistry [3].…”