An Innovative Strategy for Oral Biofilm Control in Early Childhood Based on a Resveratrol-Cyclodextrin Nanotechnology Approach

Berta, Giovanni Nicolao; Romano, Federica; Vallone, Roberta; Abbadessa, Giuliana; Scipio, Federica Di; Defabianis, Patrizia

doi:10.3390/ma14143801

Cited by 10 publications

(9 citation statements)

References 44 publications

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“…Additionally, a promising 2021 investigation by Berta et al, involved the design of an oral Nano-RES spray via encapsulation of crude RES in 2-hydroxypropylβ-cyclodextrins (i.e., RES-HPβCD) and tested its action on plaque formation in children. This study demonstrated that after using the spray once per day, the RES-HPβCD plaque was significantly reduced; the spray was also found to be doubled in efficacy when compared to tooth brushing alone [82].…”

Section: Improvement Of Res As a Therapeutic Via Nanotechnologymentioning

confidence: 72%

Trans-Resveratrol: From Phytonutrient Supplement, to Novel Nanotherapeutic Agent

Harney¹

2023

Periodontology - New Insights

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Trans-resveratrol (3,5,4′-trihydroxy-trans-stilbene) (RES) is a plant polyphenol that has been well documented for its anti-oxidant, antimicrobial, anti-inflammatory, and anti-aging properties. Moreover, compelling evidence presented in the abundance of pre-clinical studies using ligature-induced periodontitis models has positioned RES as a theoretically viable candidate for the reduction of the chronic inflammation, oxidative stress, and tissue destruction seen in periodontitis (PD). However, the instability of RES under physiological conditions, as well as its rapid hepatic clearance, has presented as a challenge to its ubiquitous application as an oral therapeutic in clinical practice. Fortunately, with the application of nanotechnology, the pharmacological profile of RES repositions the phytochemical from an herb-based supplement, useful as an adjunct therapy, to a stable and potent nanomedicine, demonstrating efficacy for the prevention and treatment of PD and its associated systemic diseases. This chapter explores the details of the potential for nano-RES as a viable therapeutic for PD.

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Section: Improvement Of Res As a Therapeutic Via Nanotechnologymentioning

confidence: 72%

Trans-Resveratrol: From Phytonutrient Supplement, to Novel Nanotherapeutic Agent

Harney¹

2023

Periodontology - New Insights

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“…Proper daily oral hygiene, fluoride applications, use of sealants, and regular dental checkups are essential to control caries development [29,30]. Early identification of caries is essential to prevent complications.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and association of dental anomalies and tooth decay in Italian childhood cancer survivors

2023

Journal of Clinical Pediatric Dentistry

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The aim of this cross-sectional study was to assess the prevalence and severity of dental anomalies according to age at cancer treatment and type of antineoplastic protocol using the Modified Dental Defect Index (MDDI) and to explore the association between MDDI scores and caries experience in Italian childhood cancer survivors (CCS). A total of 88 CCSs (age range 6–20 years) treated with chemotherapy and/or radiotherapy for malignant diseases and in remission from at least 2 years were consecutively recruited from March 2019 to July 2022. All participants were examined for dental caries and enamel defects in the permanent dentition according to the decayed-missing-filled teeth (DMFT) index and the Aine rating scale. Dental abnormalities were diagnosed using panoramic radiographs and graded for severity according to the MDDI. The MDDI values were categorized as normal (MDDI, 0), moderately abnormal (1 ≤ MDDI < 16), and severely abnormal (MDDI ≥16). None of the enrolled children had normal MDDI score. MDDI and DMFT values were higher in CCSs submitted to cancer treatment before 5 years of age, while no statistically significant association was found with anticancer protocols. A significant positive correlation emerged between DMFT and MDDI values (p < 0.001). CCSs with moderately abnormal disturbances had statistically significant lower DMFT scores (p < 0.001) than those with severe dental abnormalities. These findings suggest that children in remission from malignant diseases with MDDI values ≥16 have poorer dental health and should be strictly monitored by dental specialists.

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“…An oxacillin and rifampicin–cyclodextrin derivative has also shown significant improvement in the biofilm disruption ability of antibiotics alone. Berta et al (2021) showed that the children aged between two and five years who received oral treatment demonstrated a significant reduction in plaque formation . Further, Mishra et al (2021) showed that a β-cyclodextrin-loaded gellan/PVA complex inhibited biofilms of C. albicans and C. glabrata (approximately 70% inhibition) .…”

Section: Nanotechnological Approaches For Biofilm Controlmentioning

confidence: 99%

Advances in Nanotechnology for Biofilm Inhibition

et al. 2023

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Biofilm-associated infections have emerged as a significant public health challenge due to their persistent nature and increased resistance to conventional treatment methods. The indiscriminate usage of antibiotics has made us susceptible to a range of multidrug-resistant pathogens. These pathogens show reduced susceptibility to antibiotics and increased intracellular survival. However, current methods for treating biofilms, such as smart materials and targeted drug delivery systems, have not been found effective in preventing biofilm formation. To address this challenge, nanotechnology has provided innovative solutions for preventing and treating biofilm formation by clinically relevant pathogens. Recent advances in nanotechnological strategies, including metallic nanoparticles, functionalized metallic nanoparticles, dendrimers, polymeric nanoparticles, cyclodextrin-based delivery, solid lipid nanoparticles, polymer drug conjugates, and liposomes, may provide valuable technological solutions against infectious diseases. Therefore, it is imperative to conduct a comprehensive review to summarize the recent advancements and limitations of advanced nanotechnologies. The present Review encompasses a summary of infectious agents, the mechanisms that lead to biofilm formation, and the impact of pathogens on human health. In a nutshell, this Review offers a comprehensive survey of the advanced nanotechnological solutions for managing infections. A detailed presentation has been made as to how these strategies may improve biofilm control and prevent infections. The key objective of this Review is to summarize the mechanisms, applications, and prospects of advanced nanotechnologies to provide a better understanding of their impact on biofilm formation by clinically relevant pathogens.

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An Innovative Strategy for Oral Biofilm Control in Early Childhood Based on a Resveratrol-Cyclodextrin Nanotechnology Approach

Cited by 10 publications

References 44 publications

Trans-Resveratrol: From Phytonutrient Supplement, to Novel Nanotherapeutic Agent

Trans-Resveratrol: From Phytonutrient Supplement, to Novel Nanotherapeutic Agent

Prevalence and association of dental anomalies and tooth decay in Italian childhood cancer survivors

Advances in Nanotechnology for Biofilm Inhibition

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