An injectable silk sericin hydrogel promotes cardiac functional recovery after ischemic myocardial infarction

Song, Yu; Zhang, Cheng; Zhang, Jinxiang; Sun, Ninghui; Huang, Kun; Li, Huili; Wang, Zheng; Huang, Kai; Wang, Lin

doi:10.1016/j.actbio.2016.05.039

Cited by 128 publications

(90 citation statements)

References 58 publications

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“…The major goal of cardiac tissue engineering is to create a favorable microenvironment in ischemic regions in order to regenerate the damaged heart tissue and preserve the heart function. Stem cells, growth factors, and other bio-activate elements have been applied to treat ischemic hearts [25][26][27]. Numerous functional/therapeutic peptides have been widely applied for cardiac disease research due to their advantages of easy synthesis, low toxicity, and rapid tissue absorption [24,28].…”

Section: Discussionmentioning

confidence: 99%

A collagen hydrogel loaded with HDAC7-derived peptide promotes the regeneration of infarcted myocardium with functional improvement in a rodent model

Zhang

Wei

Zhu

et al. 2020

Journal of Molecular and Cellular Cardiology

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Section: Discussionmentioning

confidence: 99%

A collagen hydrogel loaded with HDAC7-derived peptide promotes the regeneration of infarcted myocardium with functional improvement in a rodent model

Zhang

Wei

Zhu

et al. 2020

Journal of Molecular and Cellular Cardiology

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“…However, local injection of virus was found to potentially increase the risk of ventricular arrhythmia in animal experiments, which may have a negative impact on the clinical transformation of gene therapy. In recent years, injectable hydrogels, a kind of promising synthetic biomaterials with advantages of mild gelation and cardiac-compatible properties [34,35], have been proved to improve cardiac function after local myocardial injection alone [36]. In addition, hydrogels can also encapsulate therapeutic drugs, deliver them to target areas, and subsequently achieve continuous therapeutic effects [37].…”

Section: Discussionmentioning

confidence: 99%

HGF Treatment Promotes Cardiac Function and Cardiac Repair: Meta-analysis of Pig Models With Myocardial Infarction

Chen

Wang

et al. 2020

Preprint

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Background: Previous studies reported that hepatocyte growth factor (HGF) could promote angiogenesis and cardiac function after myocardial infarction (MI) in pigs. However, the results of these studies were controversial. To clarify the therapeutic efficacy of local HGF administration after MI, we performed a systematic review and meta-analysis of data from the pig models, which could provide evidence for the feasibility of clinical HGF application.Methods: PubMed, EMBASE, and China National Knowledge Infrastructure were searched for randomized studies that correspond to our subject. The search terms included (hepatocyte growth factor OR HGF) AND (heart failure OR HF OR myocardial infarction OR MI OR AMI OR coronary heart disease OR CHD). The primary endpoint indicators were identified as the left ventricular ejection fraction (LVEF) and capillaries density. Other parameters reflecting cardiac function and ventricular remodeling were analyzed as secondary indicators, including ventricular volume, infarct size, apoptotic index and others.Results: In total, 9 studies were finally included in the meta-analysis. On comparing the cardiac function indexes, the HGF group was found to be better than the control group in regard to LVEF, stroke volume, left ventricular end-systolic volume (LVESV) and left ventricular end-diastolic volume (LVEDV). However, no statistically significant differences were found in heart rate. Furthermore, HGF treatment promotes angiogenesis in ischemic areas, which is manifested by increased capillary density. In addition, the HGF group was found to be better than the control group when it comes to infarct size, arteriole densities, and other indicators of cardiac remodeling.Conclusions: HGF treatment can effectively promote cardiac function and cardiac repair including angiogenesis, and this strategy is a promising cardio-protective approach that merits further clinical studies.

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“…Furthermore, the sericin-injected hydrogel also performed an excellent biodegradability whose advantage is promoting the recovery of acute myocardial infarction (MI) by promoting inflammation and promoting cardiomyocytes and vascular repair, with limited application due to the high cost and weaker mechanical properties (Song et al, 2016). In order to improve mechanical properties, silk fibroin (SF) is used as a raw material for hydrogel to increase hydrogel toughness and obtain an appropriate degradation rate for better therapeutic effects (Kambe and Yamaoka, 2019).…”

Section: Natural Hydrogelmentioning

confidence: 99%

“…Obviously, natural injectable hydrogels own good cardiovascular repair and biocompatibility, while the defects in uncontrolled function, rapid degradation rate, long gel formation time (Ahearne, 2014;Pena et al, 2018) and high production cost play (Song et al, 2016) a tough role of obstacle in the way to cardiovascular application. Therefore, the development of synthetic hydrogels had become researchers' hot spot.…”

Section: Natural Hydrogelmentioning

confidence: 99%

Injectable Hydrogel-Based Nanocomposites for Cardiovascular Diseases

Liao

Yang

Deng

et al. 2020

Front. Bioeng. Biotechnol.

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Cardiovascular diseases (CVDs), including a series of pathological disorders, severely affect millions of people all over the world. To address this issue, several potential therapies have been developed for treating CVDs, including injectable hydrogels as a minimally invasive method. However, the utilization of injectable hydrogel is a bit restricted recently owing to some limitations, such as transporting the therapeutic agent more accurately to the target site and prolonging their retention locally. This review focuses on the advances in injectable hydrogels for CVD, detailing the types of injectable hydrogels (natural or synthetic), especially that complexed with stem cells, cytokines, nano-chemical particles, exosomes, genetic material including DNA or RNA, etc. Moreover, we summarized the mainly prominent mechanism, based on which injectable hydrogel present excellent treating effect of cardiovascular repair. All in all, it is hopefully that injectable hydrogel-based nanocomposites would be a potential candidate through cardiac repair in CVDs treatment.

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An injectable silk sericin hydrogel promotes cardiac functional recovery after ischemic myocardial infarction

Cited by 128 publications

References 58 publications

A collagen hydrogel loaded with HDAC7-derived peptide promotes the regeneration of infarcted myocardium with functional improvement in a rodent model

A collagen hydrogel loaded with HDAC7-derived peptide promotes the regeneration of infarcted myocardium with functional improvement in a rodent model

HGF Treatment Promotes Cardiac Function and Cardiac Repair: Meta-analysis of Pig Models With Myocardial Infarction

Injectable Hydrogel-Based Nanocomposites for Cardiovascular Diseases

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