An injectable, self-healing hydrogel system from oxidized pectin/chitosan/γ-Fe2O3

Li, Deqiang; Wang, Shuya; Meng, Yu-jie; Li, Junfang; Li, Jun

doi:10.1016/j.ijbiomac.2020.09.072

Cited by 51 publications

(14 citation statements)

References 39 publications

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“…In the past decade, polymer-based hydrogels serve as a competent candidate in regulating cell behaviors like migration, angiogenesis, and differentiation. 9,10 Though polymer-based hydrogels, including cellulose, 11 chitosan, pectin, 12 and sodium alginate, 13 have been widely applied in fields like drug delivery, tissue engineering, and wearable device, 14–16 the high water content of hydrogel is often accompanied byinstability and weakmechanical properties that largely confinetheir acceptance. 17 Thus, a mountain of efforts like composite materials and cross-linking treatmenthave beenutilized to realize more stable and ductile substitutes for various applications of hydrogels.…”

Section: Introductionmentioning

confidence: 99%

Preparation of gelatin-based hydrogels with tunable mechanical properties and modulation on cell–matrix interactions

Jiang

Wang

et al. 2021

J Biomater Appl

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Natural polymer material-based hydrogels normally show inferior mechanical stability and strength to bear large deformation and cyclic loading, therefore their applications in food, biomedical and tissue engineering fields are greatly limited. In this study, gelatin-based hydrogels with remarkable stability, as well as tunable mechanical properties, were prepared via a facile method known as the Hofmeister effect. The higher concentration of potassium sulfatesolution resulted in more dehydration and molecular chain folding, thus the treated hydrogels showed significantly improved tensile and compressive modulus, and decreased equilibrium swelling ratio, as revealed by scanning electron microscopy (SEM), Fourier transform infraredspectroscopy (FTIR), and mechanical tests, etc. Additionally, the reinforced hydrogels were recoverable and biocompatible to modulate the proliferation behavior of human umbilical vein endothelial cells. In conclusion, this paper provides a facile reference for tuning mechanical properties of gelatin-based hydrogels and cell-hydrogel interactions, which show potential capacity in tissue engineering and biomedical fields.

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Section: Introductionmentioning

confidence: 99%

Preparation of gelatin-based hydrogels with tunable mechanical properties and modulation on cell–matrix interactions

Jiang

Wang

et al. 2021

J Biomater Appl

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“…Magnetic hysteresis loops of the hydrogel have S-shape over the applied magnetics and the saturation magnetization value of the hydrogel was about 4.86 emu/g. The hydrogel was found to have sustained release of 5-FU for more than 12 h in the in vitro drug release studies [149].…”

Section: Hybrid Polymeric Self-healing Hydrogels As Drug Delivery Platforms For Anti-cancer Therapymentioning

confidence: 95%

Self-Healing Hydrogels: Preparation, Mechanism and Advancement in Biomedical Applications

Shyam

Palaniappan

et al. 2021

Polymers

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Polymeric hydrogels are widely explored materials for biomedical applications. However, they have inherent limitations like poor resistance to stimuli and low mechanical strength. This drawback of hydrogels gave rise to ‘‘smart self-healing hydrogels’’ which autonomously repair themselves when ruptured or traumatized. It is superior in terms of durability and stability due to its capacity to reform its shape, injectability, and stretchability thereby regaining back the original mechanical property. This review focuses on various self-healing mechanisms (covalent and non-covalent interactions) of these hydrogels, methods used to evaluate their self-healing properties, and their applications in wound healing, drug delivery, cell encapsulation, and tissue engineering systems. Furthermore, composite materials are used to enhance the hydrogel’s mechanical properties. Hence, findings of research with various composite materials are briefly discussed in order to emphasize the healing capacity of such hydrogels. Additionally, various methods to evaluate the self-healing properties of hydrogels and their recent advancements towards 3D bioprinting are also reviewed. The review is concluded by proposing several pertinent challenges encountered at present as well as some prominent future perspectives.

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“…[ 106 ] Similar to the abovementioned three types of polysaccharides, periodate is chosen to oxidize pectin and open the vicinal hydroxyls of the glucuronic acid rings, inducing the generation of two aldehyde functions in sugar ring. These modified pectins have been reported to form the Schiff base linkages and generate the injectable hydrogels with chitosan [ 107 ] or chitosan derivatives. [ 108 ] On the other hand, since the structure of pectin is highly complex, further research is needed to discover more pectin derivatives for hydrogel preparation.…”

Section: Self‐healing Injectable Polysaccharide Hydrogelmentioning

confidence: 99%

Advances in Injectable and Self‐healing Polysaccharide Hydrogel Based on the Schiff Base Reaction

Chen

2021

Macromol. Rapid Commun.

107

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Injectable hydrogel possesses great application potential in disease treatment and tissue engineering, but damage to gel often occurs due to the squeezing pressure from injection devices and the mechanical forces from limb movement, and leads to the rapid degradation of gel matrix and the leakage of the load material. The self-healing injectable hydrogels can overcome these drawbacks via automatically repairing gel structural defects and restoring gel function. The polysaccharide hydrogels constructed through the Schiff base reaction own advantages including simple fabrication, injectability, and self-healing under physiological conditions, and therefore have drawn extensive attention and investigation recently. In this short review, the preparation and self-healing properties of the polysaccharide hydrogels that is established on the Schiff base reaction are focused on and their biological applications in drug delivery and cell therapy are discussed.

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An injectable, self-healing hydrogel system from oxidized pectin/chitosan/γ-Fe2O3

Cited by 51 publications

References 39 publications

Preparation of gelatin-based hydrogels with tunable mechanical properties and modulation on cell–matrix interactions

Preparation of gelatin-based hydrogels with tunable mechanical properties and modulation on cell–matrix interactions

Self-Healing Hydrogels: Preparation, Mechanism and Advancement in Biomedical Applications

Advances in Injectable and Self‐healing Polysaccharide Hydrogel Based on the Schiff Base Reaction

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