An injectable mechanically robust hydrogel of Kappa-carrageenan-dopamine functionalized graphene oxide for promoting cell growth

Mokhtari, Hamidreza; Kharaziha, Mahshid; Karimzadeh, F.; Tavakoli, Shima

doi:10.1016/j.carbpol.2019.03.030

Cited by 90 publications

(49 citation statements)

References 83 publications

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“…The authors used KaMA with different methacrylation degrees (low, medium, and high) and compared distinct mechanical properties of those hydrogels. n another study, Mokhtari et al [ 67 ] reported the addition of dopamine functionalized graphene oxide to the dual-crosslinkable KaMA hydrogel network. This modification eventually resulted in increased shear-thinning behavior, which, in turn, improved the injection and spraying abilities of the hydrogel.…”

Section: Applications Of Hydrogels For Wound Healingmentioning

confidence: 99%

Advanced Hydrogels as Wound Dressings

2020

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Skin is the largest organ of the human body, protecting it against the external environment. Despite high self-regeneration potential, severe skin defects will not heal spontaneously and need to be covered by skin substitutes. Tremendous progress has been made in the field of skin tissue engineering, in recent years, to develop new skin substitutes. Among them, hydrogels are one of the candidates with most potential to mimic the native skin microenvironment, due to their porous and hydrated molecular structure. They can be applied as a permanent or temporary dressing for different wounds to support the regeneration and healing of the injured epidermis, dermis, or both. Based on the material used for their fabrication, hydrogels can be subdivided into two main groups—natural and synthetic. Moreover, hydrogels can be reinforced by incorporating nanoparticles to obtain “in situ” hybrid hydrogels, showing superior properties and tailored functionality. In addition, different sensors can be embedded in hydrogel wound dressings to provide real-time information about the wound environment. This review focuses on the most recent developments in the field of hydrogel-based skin substitutes for skin replacement. In particular, we discuss the synthesis, fabrication, and biomedical application of novel “smart” hydrogels.

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Section: Applications Of Hydrogels For Wound Healingmentioning

confidence: 99%

Advanced Hydrogels as Wound Dressings

2020

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“…Due to the low viscosity during blinking and the high viscosity during interblinking, shear thinning behavior was in favor of uniform spreadability after application to the eye surface (Patere et al., 2018). Furthermore, this nature could be promising for ophthalmic administration to shield the encapsulated corneal cells from shear forces (Mokhtari et al., 2019).…”

Section: Resultsmentioning

confidence: 99%

Cubic and hexagonal liquid crystal gels for ocular delivery with enhanced effect of pilocarpine nitrate on anti-glaucoma treatment

Wang

Zhang

et al. 2019

Drug Delivery

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The objective of this work was to investigate phytantriol-based liquid crystal (LC) gels including cubic (Q 2) and hexagonal (H 2) phase for ocular delivery of pilocarpine nitrate (PN) to treat glaucoma. The gels were produced by a vortex method and confirmed by crossed polarized light microscopy, smallangle X-ray scattering, and rheological measurements. Moreover, the release behaviors and permeation results of PN from the gels were estimated using in vitro studies. Finally, the anti-glaucoma effect of LC gels was evaluated by in vivo animal experiments. The inner structure of the gels was Pn3mtype Q 2 and H 2 phase, and both of them showed pseudoplastic fluid properties based on characterization techniques. In vitro release profiles suggested that PN could be sustainably released from LC gels within 48 h. Compared with eye drops, Q 2 and H 2 gel produces a 5.25-fold and 6.23-fold increase in the P app value (p < .05), respectively, leading to a significant enhancement of corneal penetration. Furthermore, a good biocompatibility and longer residence time on precorneal for LC gels confirmed by in vivo animal experiment. Pharmacokinetic studies showed that LC gels could maintain PN concentration in aqueous humor for at least 12 h after administration and remarkably improve the bioavailability of drug. Additionally, in vivo pharmacodynamics studies indicated that LC gels had a more significant intraocular pressure-lowering and miotic effect compared to eye drops. These research findings hinted that LC gels would be a promising pharmaceutical strategy for ocular application to enhance the efficacy of anti-glaucoma.

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“…The incorporation of GOPD nanoparticles in the KaMA hydrogels allowed them to be efficiently injected by enhancing the proprieties of KaMA. The biocompatibility of this nanohybrid hydrogel was noticeably promoted by increasing the GOPD content; the authors thus concluded that the formulation could be a desirable choice for soft tissue engineering and 3-D bioprinting applications [ 200 ].…”

Section: Carrageenan In Biomedical Applicationsmentioning

confidence: 99%

Carrageenan: Drug Delivery Systems and Other Biomedical Applications

2020

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Marine resources are today a renewable source of various compounds, such as polysaccharides, that are used in the pharmaceutical, medical, cosmetic, and food fields. In recent years, considerable attention has been focused on carrageenan-based biomaterials due to their multifunctional qualities, including biodegradability, biocompatibility, and non-toxicity, in addition to bioactive attributes, such as their antiviral, antibacterial, antihyperlipidemic, anticoagulant, antioxidant, antitumor, and immunomodulating properties. They have been applied in pharmaceutical formulations as both their bioactive and physicochemical properties make them suitable biomaterials for drug delivery, and recently for the development of tissue engineering. This article provides a review of recent research on the various types of carrageenan-based biomedical and pharmaceutical applications.

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An injectable mechanically robust hydrogel of Kappa-carrageenan-dopamine functionalized graphene oxide for promoting cell growth

Cited by 90 publications

References 83 publications

Advanced Hydrogels as Wound Dressings

Advanced Hydrogels as Wound Dressings

Cubic and hexagonal liquid crystal gels for ocular delivery with enhanced effect of pilocarpine nitrate on anti-glaucoma treatment

Carrageenan: Drug Delivery Systems and Other Biomedical Applications

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