An injectable conductive Gelatin-PANI hydrogel system serves as a promising carrier to deliver BMSCs for Parkinson's disease treatment

Xue, Jinhua; Liu, Yutong; Darabi, Mohammad Ali; Tu, Genghong; Huang, Lu; Li, Ying; Xiao, Bin; Wu, Yue; Xing, Malcolm; Zhang, Lin; Zhang, Lu

doi:10.1016/j.msec.2019.03.024

Cited by 39 publications

(23 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[ 160 ] Conductive polymers, such as polyaniline, poly(3,4‐ethylenedioxythiophene) (PEDOT) and polystyrene sulfonate (PSS) are often combined with hydrogels suitable for cell culture to create 3D substrates for neuronal cell culture. [ 161 ] For instance, oligoaniline‐doped chitosan was successfully used to induce the differentiation of olfactory ecto‐mesenchymal stem cells toward dopaminergic neurons, [ 162 ] which are key actors in PD. Likewise, the embedding in biocompatible hydrogels of nanoconductive elements, such as graphene, [ 163 ] black phosphorus, [ 164 ] carbon nanotubes, [ 165 ] and nanoclay, [ 166 ] has been reported.…”

Section: Future Directions In Advanced Neural In Vitro Modelingmentioning

confidence: 99%

Bioprinting Neural Systems to Model Central Nervous System Diseases

Qiu

Bessler

Figler

et al. 2020

Adv Funct Materials

View full text Add to dashboard Cite

To date, pharmaceutical progresses in central nervous system (CNS) diseases are clearly hampered by the lack of suitable disease models. Indeed, animal models do not faithfully represent human neurodegenerative processes and human in vitro 2D cell culture systems cannot recapitulate the in vivo complexity of neural systems. The search for valuable models of neurodegenerative diseases has recently been revived by the addition of 3D culture that allows to recreate the in vivo microenvironment including the interactions among different neural cell types and the surrounding extracellular matrix (ECM) components. In this review, the new challenges in the field of CNS diseases in vitro 3D modeling are discussed, focusing on the implementation of bioprinting approaches enabling positional control on the generation of the 3D microenvironments. The focus is specifically on the choice of the optimal materials to simulate the ECM brain compartment and the biofabrication technologies needed to shape the cellular components within a microenvironment that significantly represents brain biochemical and biophysical parameters.

show abstract

Section: Future Directions In Advanced Neural In Vitro Modelingmentioning

confidence: 99%

Bioprinting Neural Systems to Model Central Nervous System Diseases

Qiu

Bessler

Figler

et al. 2020

Adv Funct Materials

View full text Add to dashboard Cite

show abstract

“…The crucial factors here are the high water content, appropriate rheological properties such as viscosity and swelling ability, good biocompatibility, and close imitation of the physiological environment between cells in electrically active tissues [111]. The most widely used additives with conductive properties are poly(3,4-ethylenedioxythiophene) (PEDOT) [112][113][114]; polyaniline (PANI) [115][116][117]; polypyrrole (Ppy) [118][119][120]; carbon materials such as incorporated graphene [87,121] or carbon nanotubes [122]; and metal nanoparticles, including gold, silver, platinum, iron oxide, and zinc oxide [122,123]. Conductive HGs may be obtained by (i) physical crosslinking, (ii) the physical mixing of conductive material and HG, (iii) covalent crosslinking, and (iv) supramolecular crosslinking, which uses the mechanisms described for self-healing [124].…”

Section: Conductive Hgsmentioning

confidence: 99%

Hydrogel Properties and Their Impact on Regenerative Medicine and Tissue Engineering

Chyzy

Płońska‐Brzezińska

2020

Molecules

View full text Add to dashboard Cite

Hydrogels (HGs), as three-dimensional structures, are widely used in modern medicine, including regenerative medicine. The use of HGs in wound treatment and tissue engineering is a rapidly developing sector of medicine. The unique properties of HGs allow researchers to easily modify them to maximize their potential. Herein, we describe the physicochemical properties of HGs, which determine their subsequent applications in regenerative medicine and tissue engineering. Examples of chemical modifications of HGs and their applications are described based on the latest scientific reports.

show abstract

“…[25,26] In addition, the insufficient dopamine can also weaken muscles and even cause Parkinson's syndrome. [27,28] Hence, it is necessary to quickly and accurately detect dopamine. At present, many methods of detecting DA have been reported including fluorescence method, [29] colorimetric method, [30] electrochemical method, [31] etc.…”

Section: Introductionmentioning

confidence: 99%

“…If the secreted dopamine is insufficient, people will have poor and indifferent mood and even cause mental illness in severe cases . In addition, the insufficient dopamine can also weaken muscles and even cause Parkinson's syndrome . Hence, it is necessary to quickly and accurately detect dopamine.…”

Section: Introductionmentioning

confidence: 99%

Preparation of a Hollow Nanocomposite with Gold‐Embedded Zeolitic Imidazolate Framework‐67 for the Electrochemical Determination of Dopamine

Dong

Zheng

2020

ChemElectroChem

View full text Add to dashboard Cite

This work employed a polystyrene sphere as a template to synthesize a hollow nanocomposite with gold-embedded zeolitic imidazolate framework-67 (H-Au@ZIF-67). The morphological and structural characteristics of the prepared composite were investigated by using scanning electron microscopy, transmission electron microscopy, X-ray diffraction and energydisperse spectroscopy, indicating that H-Au@ZIF-67 with a sunflower-shaped cross section was successfully prepared. The synthesized H-Au@ZIF-67 was used to construct a dopamine electrochemical sensor, which showed good linearity scope of 0.25-438.75 μM with a high sensitivity of 332.1 μA mM À 1 cm À 2 and low detection limit of 0.04 μM. These results showed that the H-Au@ZIF-67 can be a good electrode modification material for dopamine sensing.

show abstract

An injectable conductive Gelatin-PANI hydrogel system serves as a promising carrier to deliver BMSCs for Parkinson's disease treatment

Cited by 39 publications

References 41 publications

Bioprinting Neural Systems to Model Central Nervous System Diseases

Bioprinting Neural Systems to Model Central Nervous System Diseases

Hydrogel Properties and Their Impact on Regenerative Medicine and Tissue Engineering

Preparation of a Hollow Nanocomposite with Gold‐Embedded Zeolitic Imidazolate Framework‐67 for the Electrochemical Determination of Dopamine

Contact Info

Product

Resources

About