An injectable and biodegradable nano-photothermal DNA hydrogel enhances penetration and efficacy of tumor therapy

Pi, Wei; Hao, Mingda; Li, Yansheng; An, Heng; Li, Qicheng; Zhang, Peixun; Zhou, Liping

doi:10.1039/d1bm00568e

Cited by 35 publications

(33 citation statements)

References 68 publications

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“…All of these have positive effects on killing cancer cells [ 9 ]. Gold nanoparticles [ 64 ], indocyanine green [ 65 ], reduced graphene oxide [ 66 ], iron-oxide [ 67 , 68 ], MoS 2 [ 35 ], CuS [ 69 ], and black phosphorus quantum dots [ 36 ] have been reported as photo-responsive agents.…”

Section: Stimuli-responsive Injectable Hydrogelsmentioning

confidence: 99%

“…BPQD was to facilitate both NIR triggered photothermal and photodynamic therapy while the DOX was loaded onto polyethyleneimine particles. It was found that this system was capable of improving the drug penetration to the tumors, survival rate of breast cancer-bearing mice, and drug resistance [ 36 ].…”

Section: Stimuli-responsive Injectable Hydrogelsmentioning

confidence: 99%

“…Black phosphorus quantum dots and polyethyleneimine have been applied to prepare the injectable hydrogels with xDNA. Polyethyleneimine is known to be non-biocompatible, but the modified hydrogel system exhibited low hemolysis rate, suggesting an improved biocompatibility [ 36 ]. These two examples indicate it is still feasible to utilize some non-biocompatible materials for drug delivery fabrication after necessary modification and careful cytocompatibility measurements.…”

Section: Biocompatibilitymentioning

confidence: 99%

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Drug Delivery Based on Stimuli-Responsive Injectable Hydrogels for Breast Cancer Therapy: A Review

Xin

Naficy

2022

Gels

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Breast cancer is the most common and biggest health threat for women. There is an urgent need to develop novel breast cancer therapies to overcome the shortcomings of conventional surgery and chemotherapy, which include poor drug efficiency, damage to normal tissues, and increased side effects. Drug delivery systems based on injectable hydrogels have recently gained remarkable attention, as they offer encouraging solutions for localized, targeted, and controlled drug release to the tumor site. Such systems have great potential for improving drug efficiency and reducing the side effects caused by long-term exposure to chemotherapy. The present review aims to provide a critical analysis of the latest developments in the application of drug delivery systems using stimuli-responsive injectable hydrogels for breast cancer treatment. The focus is on discussing how such hydrogel systems enhance treatment efficacy and incorporate multiple breast cancer therapies into one system, in response to multiple stimuli, including temperature, pH, photo-, magnetic field, and glutathione. The present work also features a brief outline of the recent progress in the use of tough hydrogels. As the breast undergoes significant physical stress and movement during sporting and daily activities, it is important for drug delivery hydrogels to have sufficient mechanical toughness to maintain structural integrity for a desired period of time.

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Section: Stimuli-responsive Injectable Hydrogelsmentioning

confidence: 99%

Section: Stimuli-responsive Injectable Hydrogelsmentioning

confidence: 99%

Section: Biocompatibilitymentioning

confidence: 99%

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Drug Delivery Based on Stimuli-Responsive Injectable Hydrogels for Breast Cancer Therapy: A Review

Xin

Naficy

2022

Gels

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“…Nevertheless, most PDT photosensitizers absorb light in the visible range, resulting in limited penetration depth ( Fan et al, 2021 ). In contrast, PTT, which utilizes the photosensitizer excited by near-infrared red light, has improved the penetration depth ( Zhou et al, 2021 ). More importantly, PTT has been reportedly validated to produce a good short-term effect ( Wen et al, 2021 ; Mengya et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Biocompatible Mesoporous Silica–Polydopamine Nanocomplexes as MR/Fluorescence Imaging Agent for Light-Activated Photothermal–Photodynamic Cancer Therapy In Vivo

Lü

Chen

Huang

et al. 2021

Front. Bioeng. Biotechnol.

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Conventional cancer phototherapy with single modality suffers from low therapeutic efficacy and undesired posttreatment damage for adjacent normal tissues. Therefore, the lower NIR laser irradiation power is vital to the reduction or preclusion of risk of scalds and burns in normal tissues. Herein, we rationally proposed a novel multifunctional nanocomplex, which enabled good magnetic resonance (MR) imaging contrast effect and promising photothermal conversion efficacy. The prepared core/shell nanocomplexes [MSN-Ce6@PDA (Mn)] were composed of chlorin e6-embedded mesoporous silica/nanoparticle composites as the cores, and then polydopamine and manganese ions were conjugated on the cores to form protective shells. The MSN-Ce6@PDA (Mn) nanocomplexes revealed superior properties in colloidal stability, photothermal conversion, reaction oxygen species generation, magnetic resonance imaging, etc. Under the guidance of MR and fluorescence imaging, these MSN-Ce6@PDA (Mn) nanocomplexes were found to be primarily accumulated in the MDA-MB-231 tumor area. Furthermore, the combined photodynamic and photothermal therapy exhibited strong inhibition to the growth of MDA-MB-231 tumor in vitro and in vivo. Besides, the MSN-Ce6@PDA (Mn) nanocomplexes also exhibited excellent biocompatibility and low damage to the healthy animals. Hence, the results demonstrated that the prepared MSN-Ce6@PDA (Mn) nanocomplex would be a promising potential for multimodal imaging-guided phototherapy.

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“…Nevertheless, most PDT photosensitizers absorb light in the visible range, resulting in limited penetration depth (Fan et al, 2021). In contrast, PTT, which utilizes the photosensitizer excited by near-infrared red light, has improved the penetration depth (Zhou et al, 2021). More importantly, PTT has been reportedly validated to produce a good shortterm effect (Wen et al, 2021;Mengya et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

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An injectable and biodegradable nano-photothermal DNA hydrogel enhances penetration and efficacy of tumor therapy

Abstract: The biological barrier of solid tumors hinders deep penetration of nanomedicine, constraining anticancer treatment. Moreover, the inherent multidrug resistance (MDR) of cancer tissues may further limit the efficacy of anti-tumor...

Cited by 35 publications

References 68 publications

Drug Delivery Based on Stimuli-Responsive Injectable Hydrogels for Breast Cancer Therapy: A Review

Drug Delivery Based on Stimuli-Responsive Injectable Hydrogels for Breast Cancer Therapy: A Review

Biocompatible Mesoporous Silica–Polydopamine Nanocomplexes as MR/Fluorescence Imaging Agent for Light-Activated Photothermal–Photodynamic Cancer Therapy In Vivo

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