An Inherited Blood Group A Variant in the Finnish Population

Mohn, James F.; Cunningham, Roger K.; Pirkola, Anna; Furuhjelm, U.; Nevanlinna, H. R.

doi:10.1111/j.1423-0410.1973.tb04365.x

Cited by 11 publications

(5 citation statements)

References 18 publications

(6 reference statements)

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“…In a recent article, Mohn et al [8] reported an incidence of approximately 1:6,000 for an atypical A variant described as 'A-finn'. No study giving the incidence of weak B variants is available in the literature.…”

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confidence: 99%

Incidence of ‘Bombay’ (Oh) Phenotype and Weaker Variants of A and B Antigen in Bombay (India)

Bhatia¹,

Sathe²

1974

Vox Sanguinis

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Incidence of Oh and weaker A and B variants was studied in 167,404 Indians in Bombay. Eight out of 17 cases of A variants were due to weak A(2), the majority being among AB individuals. Incidence of all weak A is 1:3,300 among persons possessing the A antigen. The actual incidence of A variants deducting weak A(2) is approximately 1:6,000 persons having the A antigen. Weak B is observed in 1:9,300 persons possessing the B antigen. A(x)-B(x) variants were twice as common as A(m)B(m) types. The O(h) phenotype is observed in 1:7,600 random persons. The regional and caste distribution of O(h) individuals showed that 14 out of 22 of the Oh individuals in the present survey and 33 out of 58 among all Oh cases investigated belonged to south-west districts of Maharashtra.

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Section: Contentsmentioning

confidence: 99%

Incidence of ‘Bombay’ (Oh) Phenotype and Weaker Variants of A and B Antigen in Bombay (India)

Bhatia¹,

Sathe²

1974

Vox Sanguinis

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“…The Finnish variant, tentatively called Afmn, has several character istics which make it possible to distinguish the phenotype from other known variants of A. The serological properties of the red cells, serum, and saliva have been described elsewhere [2,11].…”

Section: Introductionmentioning

confidence: 99%

An Inherited Blood Group A Variant in the Finnish Population

Nevanlinna¹,

Pirkola²

1973

Vox Sanguinis

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A rare variant of blood group A, A(finn), is used as a marker when studying the Finnish population structure. Slow immigration is probably the main cause of the primary enrichment of this gene that has not yet been described outside Finland.Practically all the 98 propositi originated from the areas in the south-west and south-east that were first settled in prehistoric times. This indicates that both were inhabited by the same settlers, probably immigrating over the Gulf of Finland rather than using two different routes. The frequency of A(finn) in the first settled areas was estimated at approximately 1:1,000, showing large local differences at community level, with estimated peaks as high as more than 1%. The frequency distribution was analysed in a computer simulation programme; the similarities with the observed distribution of A(finn) were compatible with the effect of sampling and drift, causing substantial loss and large frequency deviations in the isolated subpopulations.

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“…After being read macroscopically, the tubes with their contents were re-centrifuged, the cells gently dislodged, and all of the negative reactions viewed microscopically [10]. At least ten fields were examined at low power magnification (x 100), agglutinates counted and the average num ber per field calculated, as shown in table I.…”

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confidence: 99%