An indirect approach for reference intervals establishment of immunoglobulin A, G and M: the combination of laboratory database and statistics

Chai, Jiatong; Sun, Zeyu; Zhang, Shunli; Zhou, Qi; Xu, Jiancheng

doi:10.1080/00365513.2022.2092897

Cited by 4 publications

(2 citation statements)

References 30 publications

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“…A greater proportion of high IgM was detected in eutrophic patients in the decompensated stage (59%) than in those in the compensated stage (50%) ( Figure 4 B). The main function of circulating immunoglobulins IgA, IgM, and IgG is to protect the individual against invasion by foreign pathogens [ 25 ]. IgG plays an important role in neutralization, opsonization, and sensitization to kill NK cells and activate the complement system.…”

Section: Discussionmentioning

confidence: 99%

Hypogammaglobulinemia Class G Is Present in Compensated and Decompensated Patients with Propionate Defects, Independent of Their Nutritional Status

López-Mejía,

Vela-Amieva,

Guillén-López

et al. 2024

Nutrients

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Propionate defects (PDs) mainly include methylmalonic (MMA) and propionic acidemia (PA) defects. Lifelong PD patients progress from the compensated to the decompensated stages, the latter of which are characterized by life-threatening acidemia and hyperammonemia crises. PD patients can suffer immunocompromise, especially during the decompensation stage. There is a significant gap in the research regarding the humoral immune response in PD patients. Here, we analyzed serum immunoglobulin concentrations and hemograms across compensated and decompensated stages in PD patients. Nutritional status and crisis triggers of decompensation were also explored. Twenty patients were studied, and 25 decompensation events (DE) and 8 compensation events (CE) were recorded. Compared with those in the CE group, the IgG levels in the DE group (513.4 ± 244.5 mg/dL) were significantly lower than those in the CE group (860.8 ± 456.5 mg/dL) (p < 0.0087). The mean hemoglobin concentration was significantly lower in the DE group (11.8 g/dL) than in the CE group (13.4 g/dL) (p < 0.05). The most frequent (48%) possible decompensation trigger factor was infection. Most of the events were registered in eutrophic patients (87.9%), despite which 65.2% and 50% of patients who experienced decompensated and compensated events, respectively, presented with hypogammaglobulinemia G. These findings provide evidence of the immunodeficiency of PD patients, independent of their nutritional status. We suggest that PD patients be managed as immunocompromised independently of their nutritional status or metabolic state (compensated or decompensated).

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Section: Discussionmentioning

confidence: 99%

Hypogammaglobulinemia Class G Is Present in Compensated and Decompensated Patients with Propionate Defects, Independent of Their Nutritional Status

López-Mejía,

Vela-Amieva,

Guillén-López

et al. 2024

Nutrients

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“…According to the evaluation, the best practices for non-formal education teaching and learning activities during a pandemic can be described as follow. First, distance learning such as online teaching through LMS can be the best option for teaching during a pandemic due to the contactless activity that protected both the students and teachers (Chai et al, 2022;Chan et al, 2022;Heo et al, 2021;Turnbull et al, 2021;Zainuddin et al, 2020) while maintaining a quality education. This practice is showing a good result based on the teacher's experience as the teaching and learning process can be well-maintained even under the lockdown period (Shentova et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

Best practices in the implementation of pandemic era learning in non-formal education institution

Adityo

Sudiran

Rachmayani³

et al. 2023

RADEN

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During the COVID-19 pandemic, institutions were forced to shift their teaching from face-to-face classes to online classes. In non-formal education, this means that there are different styles and approaches to teaching that are being employed without proper training or guidance as they are not following the general curriculum provided by the government. The research intended to assist non-formal education by validating their teaching and learning process during the COVID-19 period. The study follows the ADDIE (Analyze, Design, Develop, Implement, and Evaluate) model to analyze and give an evaluation of the teaching practice. The research is a form of community service assistance in determining the best practices for teaching language during a pandemic in Mayantara School Malang. The result is proposed as a reference for other non-formal education. The research resulted in best practices in managerial and teaching applications. The result is divided into three principal best practices, teaching approaches, cooperation, and material development. The non-formal education should understand these aspects well and further implement their teaching and learning activities to prepare for situations that may occur.

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The combination of circulating IgM and geriatric nutritional risk index predicts the prognostic of hepatocellular carcinoma patients who underwent immune checkpoint inhibitors

Liu

Zhao

Wang

et al. 2023

International Immunopharmacology

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An indirect approach for reference intervals establishment of immunoglobulin A, G and M: the combination of laboratory database and statistics

Cited by 4 publications

References 30 publications

Hypogammaglobulinemia Class G Is Present in Compensated and Decompensated Patients with Propionate Defects, Independent of Their Nutritional Status

Hypogammaglobulinemia Class G Is Present in Compensated and Decompensated Patients with Propionate Defects, Independent of Their Nutritional Status

Best practices in the implementation of pandemic era learning in non-formal education institution

The combination of circulating IgM and geriatric nutritional risk index predicts the prognostic of hepatocellular carcinoma patients who underwent immune checkpoint inhibitors

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