An Independent Regulation of Distinct Idiotopes of the T15 Idiotype by Autologous T Cells<sup>a</sup>

Černý, Jan; Cronkhite, R

doi:10.1111/j.1749-6632.1983.tb18052.x

Cited by 8 publications

(1 citation statement)

References 14 publications

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“…Cerny and R. Cronkhite (12) showed that some idiotopes seem to be helped, some are suppressed, and some are left autonomous. This underlines the danger of extrapolating too much from one system to another.…”

Section: Discussionmentioning

confidence: 99%

Idiotypic analysis of potential and available repertoires in the arsonate system.

Slaoui¹,

Léo²,

Marvel³

et al. 1984

The Journal of Experimental Medicine

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We have shown that, by suitable idiotypic manipulation, BALB/c mice can express the major cross-reactive idiotype (CRI) of A/J mice in response to azophenylarsonate (Ars). In order to know if the CRIA idiotype is present in the potential repertoire of BALB/c before any intentional selection, we used polyclonal activation in vitro and limiting dilution analysis. The readout was done with two monoclonal anti-CRIA antibodies that recognize distinct idiotopes on a CRIA+ A/J germline-encoded monoclonal antibody. We studied the frequency of CRIA+ lipopolysaccharide (LPS)-reactive cells in the spleens of nonimmune and immune A/J mice and in the spleens of naive and manipulated (i.e., producing CRIA+ antibodies) BALB/c mice. A/J and BALB/c naive individuals presented very high frequencies of Ars-specific B cells while the frequency of CRIA+ B cells was only a minor subset (0.5%) of the total Ars-specific subset in the two strains. When A/J mice were immunized with Ars-keyhole limpet hemocyanin, a clear preferential expansion of the CRIA+ minor subset of A/J mice was observed (100x). No such enhancement was observed in BALB/c mice similarly treated. Manipulated BALB/c mice presented a higher frequency of CRIA+ anti-Ars B cells than naive or antigen-immunized BALB/c individuals.

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Section: Discussionmentioning

confidence: 99%

Idiotypic analysis of potential and available repertoires in the arsonate system.

Slaoui¹,

Léo²,

Marvel³

et al. 1984

The Journal of Experimental Medicine

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Autologous Idiotope-Specific T Cells in Regulation of Antibody Response

Černý

1984

The Biology of Idiotypes

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Transferred B cells from autoimmune NZB/N mice fail to activate T suppressor cells

Elkins

Stashak

Baker

1987

Cellular Immunology

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An Independent Regulation of Distinct Idiotopes of the T15 Idiotype by Autologous T Cells^a

Cited by 8 publications

References 14 publications

Idiotypic analysis of potential and available repertoires in the arsonate system.

Idiotypic analysis of potential and available repertoires in the arsonate system.

Autologous Idiotope-Specific T Cells in Regulation of Antibody Response

Transferred B cells from autoimmune NZB/N mice fail to activate T suppressor cells

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An Independent Regulation of Distinct Idiotopes of the T15 Idiotype by Autologous T Cellsa

Cited by 8 publications

References 14 publications

Idiotypic analysis of potential and available repertoires in the arsonate system.

Idiotypic analysis of potential and available repertoires in the arsonate system.

Autologous Idiotope-Specific T Cells in Regulation of Antibody Response

Transferred B cells from autoimmune NZB/N mice fail to activate T suppressor cells

Contact Info

Product

Resources

About

An Independent Regulation of Distinct Idiotopes of the T15 Idiotype by Autologous T Cells^a