Transferred B cells from autoimmune NZB/N mice fail to activate T suppressor cells

Elkins, Karen L.; Stashak, Philip W.; Baker, Phillip J.

doi:10.1016/0008-8749(87)90097-9

Cited by 6 publications

(2 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Other studies show that in order for immune B cells to activate Ts, they must express Id and be able to synthesize protein either for the continued expression of cell-associated antibody after cell transfer or for the elaboration of another protein molecule required for the activation of Ts; this molecule does not appear to be Ia antigen (19). The absence (or ephemeral presence) of such a molecule might account for the inability of immune B cells from autoimmune NZB/N mice to activate Ts (18). It could also explain why existing clones of B cells bearing the Id of antibody specific for SSS-Ill do not activate Ts and Ta in a spontaneous manner in unimmunized mice.…”

Section: Signals For Activation Of Ts and Tamentioning

confidence: 99%

Regulation of magnitude of antibody response to bacterial polysaccharide antigens by thymus-derived lymphocytes

Baker

1990

Infect Immun

View full text Add to dashboard Cite

Section: Signals For Activation Of Ts and Tamentioning

confidence: 99%

Regulation of magnitude of antibody response to bacterial polysaccharide antigens by thymus-derived lymphocytes

Baker

1990

Infect Immun

View full text Add to dashboard Cite

“…elucidated. We previously showed that B cells taken from animals immunized with SSS-III can induce Ts cells in vivo and that this can occur in the absence of residual antigen (12)(13)(14)23); here, the kinetics for induction of Ts-cell activity is similar to that noted for induction of Ts cells after priming with antigen (14,21). Because the suppression induced is antigen specific, these findings have been interpreted as indicating that Ts cells are activated by recognition of idiotypic determinants of cell-associated antibody on the surface of antigen-stimulated B cells.…”

Section: Nct No Cells Transferredmentioning

confidence: 99%

Antigen-specific suppressor T cells respond to recombinant interleukin-2 and other lymphokines

et al. 1991

View full text Add to dashboard Cite

Previous studies have shown that transfer of whole spleen cell populations obtained from primed donors or transfer of purified T cells enriched for suppressor activity (Ts) to recipient mice decreased the antibody response to pneumococcal polysaccharide type Ill (SSS-III) when the animals were simultaneously immunized with SSS-III. In the present studies, such suppression of the antibody response was transferred with 10to 100-fold fewer primed spleen cells when the cells were treated in vitro with recombinant interleukin-2 (rIL-2) before transfer; spleen cells from naive mice or mice primed with an unrelated antigen (dextran) and then treated with rIL-2 did not cause suppression of the antibody response to SSS-III, thereby eliminating the possibility of nonspecific carryover effects induced by rIL-2. In vivo administration of rIL-2 at the time of immunization with an optimally immunogenic dose of SSS-III resulted in significant (P < 0.05) suppression of the antibody response relative to that of control animals, suggesting that IL-2 augments the clonal expansion of Ts cells in vivo. Further, the ability of passively administered anti-IL-2 receptor antibody to inhibit generation of Ts cells in vivo is consistent with such a view. Spleen cells from primed animals treated with rIL-4, rIL-5, or gamma interferon-but not those from primed animals treated with rIL-6-likewise were able to transfer suppression of the antibody response with fewer cells than those required when primed cells not treated with lymphokines were used. Thus, these studies indicate that Ts cell activity is greatly influenced by lymphokines produced by helper T cells. The studies also suggest that these lymphokines are required during activation and/or clonal expansion of Ts cells.

show abstract

Bacterial Polysaccharides, Endotoxins, and Immunomodulation

Baker

Taylor

Ekwunife

1992

Microbial Infections

View full text Add to dashboard Cite

Transferred B cells from autoimmune NZB/N mice fail to activate T suppressor cells

Cited by 6 publications

References 44 publications

Regulation of magnitude of antibody response to bacterial polysaccharide antigens by thymus-derived lymphocytes

Regulation of magnitude of antibody response to bacterial polysaccharide antigens by thymus-derived lymphocytes

Antigen-specific suppressor T cells respond to recombinant interleukin-2 and other lymphokines

Bacterial Polysaccharides, Endotoxins, and Immunomodulation

Contact Info

Product

Resources

About