1998
DOI: 10.1076/ceyr.17.1.53.5259
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An independent evaluation of the age-related eye disease study (AREDS) cataract grading system

Abstract: The AREDS lens opacities grading system appears to be sufficiently reliable to detect changes of at least 10% areal involvement for cortical, 15% areal involvement for posterior subcapsular, and 1.0 units for nuclear opacities. It therefore seems sufficiently sensitive to adequately monitor progression of lens opacities in a longitudinal study of patients with early cataract. Its applicability in a population with advanced or complex mixed opacities must await further testing.

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Cited by 6 publications
(3 citation statements)
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“…Although photographic image analysis densitometry, [14][15][16][17] or digital image analysis [18][19][20] as it becomes more widespread, might provide some more objective measures to enhance our preoperative assessment of cataracts and facilitate studies on progression of lens opacities, 21 the LOCSIII and other cataract grading systems have been shown to have high inter-observer and intra-observer repeatability 13,18,[22][23][24] and to demonstrate some consistency between different classifications. [24][25][26][27] New techniques such as photon spectroscopy for in vivo analysis of lenses remain to be further investigated.…”
Section: Discussionmentioning
confidence: 99%
“…Although photographic image analysis densitometry, [14][15][16][17] or digital image analysis [18][19][20] as it becomes more widespread, might provide some more objective measures to enhance our preoperative assessment of cataracts and facilitate studies on progression of lens opacities, 21 the LOCSIII and other cataract grading systems have been shown to have high inter-observer and intra-observer repeatability 13,18,[22][23][24] and to demonstrate some consistency between different classifications. [24][25][26][27] New techniques such as photon spectroscopy for in vivo analysis of lenses remain to be further investigated.…”
Section: Discussionmentioning
confidence: 99%
“…[18][19][20][21][22] The comprehensive ophthalmologic examination also included slitlamp examinations to evaluate the anterior chamber, including any cellular infiltrate or flare, lens opacification and/or cataracts (ie, nuclear sclerosis, cortical spoking, posterior subcapsular) using the AREDS grading protocol, IOP using Goldmann applanation tonometry or Tono-Pen (Reichert Ophthalmic Instruments, Depew, New York), 23 and dilated funduscopy. 14 The ERGs were recorded at all centers on the Espion E 2 ERG instrument using Dawson-Trick-Litzkow (DTL)-Plus electrodes (both by Diagnosys LLC, Lowell, Massachusetts) and following the International Society for Clinical Electrophysiology of Vision (ISCEV) protocol for full-field (Ganzfeld) ERGs. 24 The ERG instrument used a light-emitting diode flash that had a flash-to-flash intensity variability of approximately 1%.…”
Section: Assessmentsmentioning
confidence: 99%
“…There are various published grading scales that could then potentially be used to sub classify variation and abnormalities of each structure (e.g. lens 20,21 ) however further work including a literature review would be required to determine the most appropriate for primary care optometry.…”
Section: Clinical Signs Found In Anterior Eye Examinationmentioning
confidence: 99%