Retinal Effects of 6 Months of Daily Use of Tadalafil or Sildenafil

Sildenafil citrate on retrobulbar and retinal circulation of rabbits

“…Potential effects on the retina, heart and blood pressure were the targets of investigations (PACHE et al, 2002 Ciência Rural, v.44, n.8, ago, 2014. POLAK et al, 2003;AMERI et al, 2008;FORESTA et al, 2008;CORDELL et al, 2009).…”

Electroretinograms and Normative Data

“…Cordell et al, (2009) provides a framework by which one can run a successful multicenter clinical trial that utilizes ERG as a primary endpoint. Their success was dependent on standardization of not just the recording equipment but the training and personnel, both technicians and ERG readers, involved in the trial.…”

“…On-site visit during patient testing confirms performance consistency at the individual site. In the Cordell et al, (2009) study, all 15 sites received centralized training on the east and west coasts (Washington DC and Scottsdale Arizona). In addition, all 15 sites received individualized on-site refresher training all within a 4-week period following centralized training.…”

“…Multicenter recording protocols such as the one employed in Cordell et al, (2009) benefited from having a centralised electronic database of all the recordings. This allowed multiple readers to assess the complete set of data and make independent evaluations of the ERGs.…”

“…Conflicting interpretations were then reassessed as a group using the predetermined criteria established prior to the commencement of recruitment. The acceptance of this clinical trial by the FDA provides tacit approval of the methodology employed in Cordell et al, (2009).…”