An independent association of prenatal depression with wheezing and anxiety with rhinitis in infancy

Cheng, Tuck Seng; Chen, Helen; Lee, Theresa; Teoh, Oon Hoe; Lee, Bee Wah; Chee, Cornelia; Godfrey, Keith M.; Gluckman, Peter D.; Kwek, Kenneth; Saw, Seang Mei; Chong, Yap Seng; Meaney, Michael J.; Broekman, Birit F.P.; Chay, Oh Moh; Bever, Hugo Van; Goh, Angela

doi:10.1111/pai.12453

Cited by 34 publications

(46 citation statements)

References 37 publications

(47 reference statements)

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“…A trend for an inverse association between postnatal depression and AD was also observed. These findings are compatible with several studies on childhood atopic disease associations with maternal prenatal or postnatal stressors [13, 16–18, 59, 103], prenatal anxiety but not depression, as suggested above [88, 104–107]. Mutual adjustment for anxiety and depression may have uncovered the negative influence of postnatal depression on the health care utilization for infant care and thus, physician diagnosis of AD [108].…”

Section: Discussionsupporting

confidence: 90%

Maternal sensitivity and social support protect against childhood atopic dermatitis

Létourneau

Kozyrskyj

Cosic

et al. 2017

Allergy Asthma Clin Immunol

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BackgroundMany studies have identified associations between qualities of maternal–child relationships and childhood asthma, but few have examined associations with childhood atopic dermatitis (AD), a common precursor to asthma. Moreover, maternal psychological distress, including prenatal and postnatal depression, anxiety and stress, may increase risk, while social support from partners may reduce risk for childhood AD. We sought to uncover the association between maternal–infant relationship qualities (maternal sensitivity towards infant behavioral signals, controlling behavior, and unresponsiveness) and child AD after accounting for risk (i.e., prenatal and postnatal maternal depression, anxiety and stress) and protective (i.e., social support) factors.MethodsWe conducted a secondary analysis of data collected on a subsample of 242 women and their infants enrolled during pregnancy in the ongoing Alberta Pregnancy Outcomes and Nutrition cohort study. Inclusion criteria required mothers to be >16 years of age, English speaking and <22 weeks gestational age at enrollment. Data on depression, anxiety and stress in the prenatal and postnatal periods and physician diagnosis of childhood AD at 18 months were gathered via maternal report. Maternal sensitivity, unresponsiveness and controlling behaviours were assessed via videotaped observations using the Child-Adult Relationship Experimental (CARE)-Index at 6 months of infant age.ResultsHigher maternal sensitivity, or the inability of the mother to appropriately understand and respond to infant needs based on behavioral signals, predicted reduced odds of AD independent of and in combination with low prenatal and postnatal anxiety and high paternal support. After adjustment, higher maternal controlling behaviours and unresponsiveness also predicted greater odds of AD.ConclusionsLow maternal sensitivity is a risk factor for childhood AD, independently and in combination with perinatal anxiety and low social support. Thus, interventions that improve maternal–infant relationship quality, especially sensitivity, reduce anxiety and improve social support from partners could reduce odds of childhood AD.

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Section: Discussionsupporting

confidence: 90%

Maternal sensitivity and social support protect against childhood atopic dermatitis

Létourneau

Kozyrskyj

Cosic

et al. 2017

Allergy Asthma Clin Immunol

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“…13,15,40 However, other studies from Europe and Singapore showed no effect. [19][20][21] Ascertainment of maternal depression and child AD differed across these studies, as did confounders adjusted for in analysis. It is also possible that differences in societal stigma towards mental health among populations from different cultures may have played a role, altering both self-reporting of psychiatric disease and maternal prenatal immune environment.…”

Section: Discussionmentioning

confidence: 99%

“…[9][10][11] Maternal stress during pregnancy and a history of psychiatric disease have been identified as possible risk factors for AD development in the offspring, [12][13][14][15][16][17][18] although these findings are not universal. [19][20][21][22][23] Notably, method of AD ascertainment and selection of controls differ across these studies, with some studies utilizing standardized symptom-based questionnaires, 12,13,[15][16][17]20 while others used self-reported physician-diagnosed eczema, 12,13,20 or AD, 14 and others relied on physical examination and clinical AD criteria. 15,21 Using different definitions of AD can significantly change risk estimates.…”

Section: Introductionmentioning

confidence: 99%

“…[19][20][21][22][23] Notably, method of AD ascertainment and selection of controls differ across these studies, with some studies utilizing standardized symptom-based questionnaires, 12,13,[15][16][17]20 while others used self-reported physician-diagnosed eczema, 12,13,20 or AD, 14 and others relied on physical examination and clinical AD criteria. 15,21 Using different definitions of AD can significantly change risk estimates. 24 Additionally, the positive associations between maternal stress/ psychiatric disease and factors that can affect the child's AD development risk, such as smoking in the home, 25 urban living 26,27 and lower socio-economic position, 28,29 can be difficult to precisely account for in these studies.…”

Section: Introductionmentioning

confidence: 99%

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Exploring the association between parental psychiatric disease and childhood atopic dermatitis: a matched case–control study

Hamann

Egeberg

Silverberg

et al. 2018

Acad Dermatol Venereol

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Background Maternal prenatal psychiatric disease has been identified as a possible risk factor for atopic dermatitis development in her children. We quantified the associations between maternal and paternal psychiatric disease and the development of atopic dermatitis in their offspring using nationwide registries.Methods All children in Denmark born between 1 January 1996 and 31 December 2011 who developed atopic dermatitis prior to their fifth birthday were identified and individually matched 1:10 with controls from the general population and with children receiving care in a similar ambulatory/hospital setting. Conditional logistic regression was used to calculate odds ratios (OR) with 95% confidence intervals.Results A total of 8602 children with atopic dermatitis were matched with controls. Rates of parental psychiatric care were similar in the atopic dermatitis and control groups. When compared to the general population, weak associations were found between childhood atopic dermatitis and maternal history of depression [OR 1.18 (95% confidence interval:

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“…This instrument is well tested for its psychometric properties in international [7577] and local setting [78]. The Cronbach's alpha value of the instrument is 0.8 in local setting [78].…”

Section: )mentioning

confidence: 99%

Evaluation of Technology-Based Peer Support Intervention Program for Preventing Postnatal Depression: Protocol for a Randomized Controlled Trial (Preprint)

Shorey¹,

Chee²,

Chong³

et al. 2017

Preprint

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An independent association of prenatal depression with wheezing and anxiety with rhinitis in infancy

Abstract: This study suggests that there may be an independent effect of prenatal depression on wheezing and anxiety on rhinitis in infancy.

Cited by 34 publications

References 37 publications

Maternal sensitivity and social support protect against childhood atopic dermatitis

Maternal sensitivity and social support protect against childhood atopic dermatitis

Exploring the association between parental psychiatric disease and childhood atopic dermatitis: a matched case–control study

Evaluation of Technology-Based Peer Support Intervention Program for Preventing Postnatal Depression: Protocol for a Randomized Controlled Trial (Preprint)

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