An increasing trend of neonatal invasive multidrug-resistant group B streptococcus infections in southern China, 2011&amp;ndash;2017

Gao, Kankan; Guan, Xiaoshan; Zeng, Ling‐Li; Qian, Jiabi; Zhu, Sufei; Deng, Qiulian; Zhong, Huamin; Pang, Shu-Ying Marissa; Gao, Fei; Jielin, Wang; Long, Yan; Chang, Chien‐Yi; Liu, Haiying

doi:10.2147/idr.s178717

Cited by 19 publications

(13 citation statements)

References 32 publications

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“…In the present study, the colonization rate of GBS was 7.27%. Our findings agreed with the results in two reports from Chengdu and Beijing [10,11]. Similar findings were also reported from those in Japan, Malaysian and Korea whose colonization rates of GBS are 8.2%, 7.5% and 8.0% respectively [12][13][14].…”

Section: Discussionsupporting

confidence: 93%

Identification and characteristics of antimicrobial-resistant Group B Streptococcus isolated from maternal birth canals at a university-affiliated hospital, China

Zhang¹,

Liu²,

Liu³

et al. 2021

Clinical and Experimental Obstetrics & Gynecology

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This study aimed to ascertain the colonization rate of Group B Streptococcus (GBS) in the birth canals of latepregnant women, and to demonstrate the characteristics of the origins of antibiotic-resistance. Materials and Methods: A prospective survey of pregnant women from 2017 to 2019 at a university-a filiated hospital in China was conducted. A total of 275 pregnant women with a pregnancy between 35 and 37 weeks were included in the study. Vaginal secretions and rectal swabs were tested by GBS separation to identify cultures, and an agar doubling dilution method was performed to assess drug sensitivity. Results: In 275 pregnant women, 20 cases were GBS screen-positive for the vaginal swabs with a GBS colonization rate of 7.27%. In addition, 16 isolates from the rectal swabs were also GBS screen-positive. Of 20 isolates from the vaginal swabs, 90.0% were resistant to tetracycline, 70.0% were resistant to erythromycin, 40.0% were resistant to clindamycin, 40.0% were resistant to levo loxacin and 30.0% resistant to chloromycetin. All isolates were susceptible to penicillin G, vancomycin, and linezolid. Conclusions: The higher prevalence of GBS colonization among pregnant women indicated the critical need for screening GBS colonization in late-pregnant women in the region. The study revealed the resistant patterns of GBS colonization and inferred a possible mechanism of the GBS resistance to antimicrobial agents used as animal growth promotion substances.

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Section: Discussionsupporting

confidence: 93%

Identification and characteristics of antimicrobial-resistant Group B Streptococcus isolated from maternal birth canals at a university-affiliated hospital, China

Zhang¹,

Liu²,

Liu³

et al. 2021

Clinical and Experimental Obstetrics & Gynecology

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“…Antibiotic susceptibilities reported in different studies from the same region might corroborate each other. A recent study from Guangzhou showed an increasing trend of multidrug-resistant bacteria in neonatal invasive infections 34. Another study conducted in Guangzhou also reported the high and continuously increasing resistance rates among Gram-positive bacteria 35.…”

Section: Discussionmentioning

confidence: 99%

<p>Nine-year analysis of isolated pathogens and antibiotic susceptibilities of microbial keratitis from a large referral eye center in southern China</p>

Lin¹,

Duan²,

Yang³

et al. 2019

IDR

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Purpose: To analyze the genus profile of isolated pathogens and antibiotic susceptibility trends of microbial keratitis over nine years at a large referral eye center in southern China. Methods: Data of corneal specimens from January 2010 to August 2018 of patients clinically diagnosed with infectious keratitis were obtained from the center’s microbiology database. Results with positive cultures along with antibiotic susceptibility were reviewed and analyzed. Results: We collected and reviewed 7,229 specimens, including 3,092 with positive cultures. Among them, 1,630 (52.72%) were bacterial, 1781 (57.60%) were fungal, and 319 (10.32%) were coinfected. A significant decreasing trend was observed in the isolates of Gram-positive cocci (r =−0.711, P =0.032), among which the proportion of coagulase-negative staphylococcus (CNS) was also reduced (r =−0.883, P =0.002). In contrast, an increasing trend in the proportion of Gram-negative bacilli was observed (r=0.661, P =0.053). The susceptibility rates of Gram-positive cocci to cephalosporins were near 90%, which was relatively high compared to fluoroquinolones. Fluoroquinolones represented the antibiotics to which Gram-negative bacilli were the most susceptible. Their susceptibility to moxifloxacin was 78.79%. The overall performance of aminoglycosides and vancomycin was both around 70%. The susceptibility of Gram-positive cocci to several antibiotics including levofloxacin (r=−0.717, P =0.03), tobramycin (r= −0.933, P <0.001), cefazolin (r= −0.964, P <0.001), ceftazidime (r=−0.929, P =0.003), chloramphenicol (r=−0.929, P =0.003), and cefuroxime (r=−0.829, P =0.042) decreased over time. The susceptibility of Gram-negative bacilli to ofloxacin increased over time (r=0.854, P =0.004), whereas that to cefazolin (r=−0.833, P =0.005) and chloramphenicol (r=−0.886, P =0.019) decreased over time. Conclusion: From 2010 to 2018 in Zhongshan Ophthalmic Center, most isolates from infectious keratitis were Gram-positive cocci (mainly CNS), which decreased over time, with an increase in Gram-positive bacilli. More than half of the antibiotics showed reducing trend of susceptibilities, and the antibiotic resistance situation in southern China was not encouraging.

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“…However, the high incidence rate of extended-spectrum β-lactamase producers and the high resistance to ampicillin and the third-generation cephalosporins continue to suggest that serious concern is warranted. Regardless of the high resistance reported consistently to erythromycin or clindamycin, penicillin or ampicillin is effective against GBS in China 5,21,26. In general, empirical therapy should be guided by the antimicrobial resistance patterns of bacterial isolates commonly detected.…”

Section: Discussionmentioning

confidence: 99%

<p>Incidence, Bacterial Profiles, And Antimicrobial Resistance Of Culture-Proven Neonatal Sepsis In South China</p>

Gao¹,

Fu²,

Guan³

et al. 2019

IDR

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BackgroundNeonatal sepsis (NS) is one of the leading causes of infant morbidity and mortality, but little is known about pathogen incidence and distribution in China.MethodsIn this retrospective study (January 2012 to December 2016), culture-proven cases aged less than 28 days with diagnosed NS in the Guangzhou Women and Children’s Medical Center, South China, were analyzed for pathogen incidence and antimicrobial resistance.ResultsA total of 620 isolates were identified from 597 NS cases. Gram-negative bacteria (n=371, 59.8%) dominated over Gram-positive bacteria (n=218, 35.2%) and fungi (n=30, 4.8%). Klebsiella pneumoniae (21.9%), Escherichia coli (21.9%), group B Streptococcus (GBS, 13.2%), and Staphylococcus aureus (6.8%) were the four most predominant pathogens. In early-onset sepsis (EOS), GBS (30.0%) and E. coli (20.0%) were dominant, whereas in late-onset sepsis (LOS), K. pneumoniae (25.6%) and E. coli (22.4%) were dominant. E. coli (25.2%) and GBS (17.7%) were the most frequently isolated from term patients, whereas K. pneumoniae was the most frequently isolated from preterm patients (34.9%). Of the infected infants, 9.5% died from sepsis, most commonly by E. coli infection (16.2%). Among 91,215 live births (LBs) delivered in the study hospital (2012–2016), 252 infants developed sepsis infection (2.76 per 1000 LBs, 95% CI 2.4–3.1), including EOS (0.78 per 1000 LBs) and LOS (2.13 per 1000 LBs). All GBS isolates were susceptible to β-lactam antibiotics, and S. aureus, including methicillin-resistant isolates, were susceptible to vancomycin. An extended-spectrum β-lactamase producer was identified in 37.3% of E. coli and 50.4% of K. pneumoniae.ConclusionK. pneumoniae was the most frequent pathogen in culture-proven NS in South China, primarily associated with LOS in preterm, whereas GBS was the dominant pathogen in EOS. E. coli was common in both episodes with the highest mortality.

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An increasing trend of neonatal invasive multidrug-resistant group B streptococcus infections in southern China, 2011–2017

Cited by 19 publications

References 32 publications

Identification and characteristics of antimicrobial-resistant Group B Streptococcus isolated from maternal birth canals at a university-affiliated hospital, China

Identification and characteristics of antimicrobial-resistant Group B Streptococcus isolated from maternal birth canals at a university-affiliated hospital, China

<p>Nine-year analysis of isolated pathogens and antibiotic susceptibilities of microbial keratitis from a large referral eye center in southern China</p>

<p>Incidence, Bacterial Profiles, And Antimicrobial Resistance Of Culture-Proven Neonatal Sepsis In South China</p>

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