An increased incidence of haemangiomas in infants born following chorionic villus sampling (CVS)

Burton, Barbara K.; Schulz, Charlene J.; Angle, Brad; Burd, Larry

doi:10.1002/pd.1970150302

Cited by 160 publications

(99 citation statements)

References 11 publications

(6 reference statements)

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“…1,3,6 Despite the significant association that has been shown between invasive procedures during pregnancy such as chorionic villus sampling and the appearance of hemangiomas, 22 this was not confirmed in the present study, since none of the mothers in this sample had been submitted to this procedure.…”

Section: Discussioncontrasting

confidence: 53%

Abordagem terapêutica dos hemangiomas cutâneos na infância

A¹,

Soares²,

Júnior³

et al. 2010

An. Bras. Dermatol.

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BACKGROUND: Hemangiomas are benign, self-involuting tumors of endothelial cells that are common in childhood. OBJECTIVES: To evaluate the treatment of 122 patients with skin hemangiomas treated at a teaching hospital in Brasilia, Brazil between March 2000 and December 2006. MATERIAL AND METHODS: Data were collected from the patients' medical records and questionnaires were applied to the children's parents. Variables analyzed were: gender, pre-and perinatal factors, clinical characteristics of the lesions, type of treatment and outcome. RESULTS: A male-to-female ratio of 1.5:1 was found. In 42 patients, hemangiomas were superficial, while in 13 cases they were deep and in 67 patients lesions were mixed. In 7 patients, the lesions were associated with syndromes. In 79 patients, hemangiomas were in the cephalic region. Of the 122 patients, 98 were submitted to one single treatment, while 24 required multiple forms of treatment. In the first group, expectant management was the conduct in 38 patients, compression in 3 cases, systemic corticotherapy in 18 patients, intralesional corticotherapy in 13, topical steroids in 4 cases, conventional surgery in 12 patients, cryosurgery in 7, pulsed light in one case and imiquimod in 2 patients. In the second group of 24 patients submitted to multiple treatment modalities, 15 required two types of treatment and 9 needed three or more. CONCLUSIONS: The data obtained in this study were in agreement with results in the literature with respect to gender and the site of the lesions. The incidence of hemangiomas present at birth was higher than rates published in the literature. The therapeutical results obtained were comparable with data from other published studies. Identification of hemangiomas that require treatment, as well as the right moment for intervention and the best therapeutic option for each case, are factors that need to be taken into consideration. Keywords: corticosteroids; combined therapy; cryosurgery; outcome of therapeutic interventions; general surgery; hemangioma; therapeutics Resumo: FUNDAMENTOS: Hemangioma é um tumor benigno de células endoteliais comum na infância e de involução espontânea. OBJETIVO: Avaliar os tratamentos utilizados em 122 pacientes com hemangiomas cutâ-neos, tratados no Hospital Universitário de Brasília, de março de 2000 a dezembro de 2006. MÉTODOS: Utilizou-se coleta de dados em prontuários e aplicação de questionários aos pais. Foram analisados gênero, fatores pré-natais e perinatais, características clínicas, tipo de tratamento e resultados. RESULTADOS: A razão de sexo (F: M) foi de 1,5:1. 42, em pacientes que apresentavam hemangiomas superficiais, 13 profundos e 67 mistos; em 7 pacientes, havia associação com síndromes. Em 79 pacientes, localizavam-se no polo cefálico. Já em 98/122 dos pacientes, foram submetidos a tratamento único e 24/122 a múltiplos. No primeiro grupo, foi utilizada conduta expectante em 38 pacientes, compressão em 3, corticoide sistêmico em 18, corticoide intralesional em 13, corticoide tópico em 4, cir...

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Section: Discussioncontrasting

confidence: 53%

Abordagem terapêutica dos hemangiomas cutâneos na infância

A¹,

Soares²,

Júnior³

et al. 2010

An. Bras. Dermatol.

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“…Nevertheless, the placental origin theory is attractive, because it would explain the exclusively perinatal or congenital presentation of hemangiomas. The otherwise puzzling observation that chorionic villus sampling increases the risk of hemangiomas (20,21) further supports this model, since the local placental injury caused in this procedure might increase shedding of endothelial cells from chorionic villi into the fetal circulation.…”

Section: Developmental Origins Of Hemangiomasmentioning

confidence: 67%

Pathogenesis of hemangioma

Marchuk

2001

J. Clin. Invest.

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“…No other tissue jointly expresses these markers. A placental origin would explain the 3-fold higher incidence of hemangiomas in infants born after transcervical chorionic villus sampling (21) and the association between hemangioma and prematurity (22) because prematurity may result from placental complications (13).…”

mentioning

confidence: 99%

Evidence by molecular profiling for a placental origin of infantile hemangioma

Barnes

Huang

Kaipainen

et al. 2005

Proc. Natl. Acad. Sci. U.S.A.

176

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The origin of the pathogenic endothelial cells in common infantile hemangioma is unknown. We show here that the transcriptomes of human placenta and infantile hemangioma are sufficiently similar to suggest a placental origin for this tumor, expanding on recent immunophenotypical studies that have suggested this possibility [North, P. E., et al. (2001) Arch. Dermatol. 137, 559 -570]. The transcriptomes of placenta, hemangioma, and eight normal and diseased tissues were compared by hierarchical and nonhierarchical clustering analysis of >7,800 genes. We found that the level of transcriptome similarity between placenta and hemangioma exceeded that of any other tissue compared and paralleled that observed between a given tissue and its derived tumor, such as normal and cancerous lung. The degree of similarity was even greater when a subset of endothelial cell-specific genes was analyzed. Genes preferentially expressed in both placenta and hemangiomas were identified, including 17-␤ hydroxysteroid dehydrogenase type 2 and tissue factor pathway inhibitor 2. These data demonstrate the value of global molecular profiling of tissues as a tool for hypothesis-driven research. Furthermore, it suggests that the unique self-limited growth of infantile hemangioma may, in fact, mirror the lifetime of placental endothelium.angiogenesis ͉ endothelium ͉ microarray ͉ gene array

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An increased incidence of haemangiomas in infants born following chorionic villus sampling (CVS)

Cited by 160 publications

References 11 publications

Abordagem terapêutica dos hemangiomas cutâneos na infância

Abordagem terapêutica dos hemangiomas cutâneos na infância

Pathogenesis of hemangioma

Evidence by molecular profiling for a placental origin of infantile hemangioma

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