An Increase in Body Temperature During Radiofrequency Ablation of Liver Tumors

Sawada, Maiko; Watanabe, Seiji; Tsuda, Hideaki; Kano, Tatsuhiko

doi:10.1097/00000539-200206000-00007

Cited by 8 publications

(6 citation statements)

References 18 publications

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“…Consistent with previous studies, we observed a significant increase in body temperature during and after percutaneous 'hepatic RFA' (17). However, a clear correlation between applied energy and increase in body temperature could not be established in this small patient population.…”

Section: Discussionsupporting

confidence: 92%

“…However, a clear correlation between applied energy and increase in body temperature could not be established in this small patient population. The hypothesis of local hepatic hyperthermia, leading to systemic heating via intra-hepatic blood flow, comparable to a 'heat exchanger' (17), is supported by the transient normalization of body temperature measured immediately after the procedure. However, differences in tumor location and vascularization make it impossible to predict the systemic warming effect from the total amount of applied energy.…”

Section: Discussionmentioning

confidence: 95%

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Case Study of Hepatic Radiofrequency Ablation Causing a Systemic Inflammatory Response Under Total Intravenous Anesthesia

et al. 2010

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ObjectiveTo investigate the effects of hepatic radiofrequency ablation (RFA) in patients with malignant liver disease with respect to inflammation activation and stress response.Materials and MethodsIn an observational trial, we investigated the physiologic parameters of 17 patients (20 interventions) who underwent percutaneous RFA under general anesthesia after applying total intravenous anesthesia. TNFα, IL-6, IL-8, IL-10, adrenaline and noradrenaline, liver enzymes, lactate and creatine kinase were determined pre-interventionally after induction of anesthesia (T1), 90 minutes after initiation of RFA (T2), immediately after the conclusion of the procedure (T3), and 24 hours after the procedure (T4).ResultsA significant increase in body temperature (p < 0.001), and mean arterial pressure (p = 0.001) were measured intraoperatively (T2) and the day after the procedure (T4). Increased levels of IL-6 were measured at T3 and T4 (p = 0.001). IL-10 increased immediately after the procedure (T3; p = 0.007). IL-6 levels correlated well with the total energy applied (r = 0.837). Significant increases in the levels of adrenaline and noradrenaline were present at T3 and T4 (p < 0.001). The RFA-induced destruction of hepatic tissue was associated with increased levels of AST, ALT, GLDH and LDH.ConclusionPercutaneous RFA of hepatic malignancies causes an inflammatory and endocrine activation, similar to the systemic inflammatory response syndrome. These effects have to be taken in account when dealing with patients susceptible to sepsis or multi-organ failure.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 95%

Case Study of Hepatic Radiofrequency Ablation Causing a Systemic Inflammatory Response Under Total Intravenous Anesthesia

et al. 2010

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“…Elevations in patient body temperature have been observed as a result of RFA. In one small series, 10 of 11 patients who underwent RFA of hepatic lesions were noted to have elevations of body temperature ranging from 0.5 C to 2.3 o C during the procedure, with three patients showing rise in temperature above 38 o C. 25 In another study of 15 patients also undergoing RFA of liver tumors, the mean rectal temperature increased from 36.3 o C þ 0.5 o C to 37.0 o C þ 1.0 o C. 26 Although no deleterious effects have been reported as a result of such increases, close observation and preparation of cooling measures has been suggested to prevent hyperthermia and its untoward metabolic consequences.…”

Section: Thermal Effectsmentioning

confidence: 99%

Complications of Radiofrequency Ablation of Neoplasms

Nemcek

2006

Semin intervent Radiol

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Radiofrequency ablation (RFA) is one of several techniques currently available to the interventional radiologist for direct local destruction of neoplastic tissue. At the present time RFA is among the most widely used and investigated of local therapies and has shown promise in oncological therapy for a variety of tissue types and anatomic locations, the latter including liver, kidney, bone, lung, and adrenal gland. This review will discuss risks of RFA, including methods to anticipate, avoid, ameliorate, or treat complications that may occur as a result of RFA.KEYWORDS: Radiofrequency ablation, complications, interventional radiology, review, neoplasm, malignancyObjectives: Upon completion of this article, the reader should be able to (1) describe at least three complications related to electrode insertion and removal during radiofrequency ablation, (2) describe at least three complications related to the thermal effects of radiofrequency ablation, and (3) discuss organ-specific complications related to radiofrequency ablation, including liver, lung, kidney, and adrenal glands. Accreditation: Tufts University School of Medicine (TUSM) is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. Credit: TUSM designates this educational activity for a maximum of 1 Category 1 credit toward the AMA Physicians Recognition Award. Each physician should claim only those credits that he/she actually spent in the activity.

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“…This may be due to the decrease of immunosuppression cytokines after the tumor coagulation necrosis, releasing the suppression of NK cell proliferation. The increase in body temperature [12] during RFA of liver tumors may be the other explanation of increased NK cells [13] .…”

Section: Discussionmentioning

confidence: 99%

Effects of radiofrequency ablation on lymphocyte subsets and type 1/type 2 T cell subpopulations in patients with hepatocellular carcinoma

Wang¹,

Xu²,

Liu³

et al. 2009

Chin. J. Cancer Res.

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Objective: To evaluate whether radiofrequency ablation (RFA) might have an influence on immune status in hepatocellular carcinoma (HCC) patients.Methods: We measured the T lymphocytes, B lymphocyte and NK cells, and determined the population of Th1, Th2, Tc1 and Tc2 of peripheral blood samples taken from 26 HCC patients before and after RFA.Results: The proportion of Type1 cells (Th1 and Tc1) and NK cells were significantly increased after RFA, especially in patients of the following subgroups: male, age>55 years, pathological grade I-II tumor, clinical stage I-II or Child-Pugh A and B.Conclusion: Type1 cells and NK cells in HCC patients were increased in a short period after RFA.

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An Increase in Body Temperature During Radiofrequency Ablation of Liver Tumors

Abstract: The increase in body temperature (BT) is predictable during radiofrequency ablation (RFA) of liver tumors under general anesthesia. Close observation of total output energy delivered and BT are required, and preparation of cooling measures is important, in RFA of liver tumors.

Cited by 8 publications

References 18 publications

Case Study of Hepatic Radiofrequency Ablation Causing a Systemic Inflammatory Response Under Total Intravenous Anesthesia

Case Study of Hepatic Radiofrequency Ablation Causing a Systemic Inflammatory Response Under Total Intravenous Anesthesia

Complications of Radiofrequency Ablation of Neoplasms

Effects of radiofrequency ablation on lymphocyte subsets and type 1/type 2 T cell subpopulations in patients with hepatocellular carcinoma

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