An Incidentally Found Inflamed Uterine Myoma Causing Low Abdominal Pain, Using Tc-99m-Tektrotyd Single Photon Emission Computed Tomography-CT Hybrid Imaging

Zandieh, Shahin; Schütz, Matthias; Bernt, Reinhard; Zwerina, Jochen; Haller, Joerg

doi:10.3348/kjr.2013.14.5.841

Cited by 7 publications

(6 citation statements)

References 6 publications

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“…Four false positive uptakes were seen in the region of biopsy, in the thyroid and in the left ureter. A possible reason for false positive findings could be inflammation and the slow excretion of the radiopharmaceutical [ 20 , 21 ]. In our study, 18 F-FDG PET/CT had a higher sensitivity than TCT, probably due to the larger group of patients with G2/G3, and poorly differentiated NETs included in the cohort, which correlates with the results in other studies [ 22 – 25 ].…”

Section: Discussionmentioning

confidence: 99%

Diagnostic and prognostic value of 99mTc-Tektrotyd scintigraphy and 18F-FDG PET/CT in a single-center cohort of neuroendocrine tumors

et al. 2021

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IntroductionThe aim was to assess the diagnostic value of 99mTc-Tektrotyd scintigraphy (TCT) and positron emission tomography/computed tomography using F-18 fluorodeoxyglucose (18F-FDG PET/CT) in the detection and follow-up of neuroendocrine tumors (NETs), and their predictive value for disease progression.Material and methodsIn this retrospective cohort, TCT and 18F-FDG PET/CT were performed in 90 patients (37 men, 53 women, mean age 52.7 ±15.1), with NET. Correlation of Ki67 and tumor grade versus Krenning score and SUVmax was assessed, Kaplan-Meier analysis was used for progression-free survival (PFS), and Cox regression analysis was performed to identify the association between progression-related factors and PFS.ResultsOut of 90, true positive TCT was detected in 56 (62.2%) patients, true negative in 19 (21.1%), false positive in 4 (4.4%), false negative in 11 (12.2%), while 18F-FDG PET/CT was true positive in 69 (76.7%) patients, true negative in 10 (11.1%), false positive in 5 (5.5%), false negative in 6 (6.7%). Mean 18F-FDG PET/CT SUVmax was 6.8 ±6.2. Diagnostic sensitivity of TCT was 83.6%, specificity 82.6%, accuracy 83.3% vs. 18F-FDG PET/CT sensitivity was 92.0%, specificity 66.7%, accuracy 87.8%. A significant correlation between Ki67 and SUVmax was found in positive 18F-FDG PET/CT findings, unlike the correlation between Ki67 and Krenning score. Median PFS was 25 months (95% CI: 18.2–31.8), in 18F-FDG PET/CT positive patients 23 months (95% CI: 16.3–29.7) and 18F-FDG PET/CT negative 26 months (p = 0.279). Progression-free survival predictors were SUVmax and Krenning score.ConclusionsIn our study, TCT and 18F-FDG PET/CT have high diagnostic accuracy in detection of NET. Higher Krenning score on TCT and SUVmax in positive 18F-FDG PET/CT findings are predictors of disease progression. 99mTc-Tektrotyd scintigraphy and 18F-FDG PET/CT can be useful complementary tools in management of patients with NETs and in predicting patients’ outcome.

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Section: Discussionmentioning

confidence: 99%

Diagnostic and prognostic value of 99mTc-Tektrotyd scintigraphy and 18F-FDG PET/CT in a single-center cohort of neuroendocrine tumors

et al. 2021

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“…Uterine leiomyoma is the most common benign pelvic tumor in women (2,3). 111 In-octreotide uptake around an intramural myoma that shows peripheral calcification on CT has been attributed to inflammatory processes (2).…”

Section: Discussionmentioning

confidence: 99%

99mTc-Octreotide Uptake in the Uterus and a Subserosal Myoma Mimicking Tumoral Masses

Pirayesh

Amoui

Assadi

2014

Journal of Nuclear Medicine Technology

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The diagnostic usefulness of somatostatin receptor scintigraphy in the localization of tumors has been evaluated in several studies. Here, we present the case of a patient with a subserosal myoma diagnosed by 99m Tc-labeled octreotide acetate scintigraphy. Oval and ring-shaped areas of hyperactivity in the pelvis were confirmed on MR imaging to be the uterus and a subserosal myoma. The presented case indicates that somatostatin receptors may be present in the uterus and in leiomyomas, especially in young women, and demonstrates that somatostatin may be a promising therapy for treatment of myoma. The case also demonstrates that subserosal myoma or dislocation of the uterus can result in a false-positive diagnosis, highlighting the importance of correlative imaging for accurate interpretation of the study.

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“…Section examined ( E and F ) from the intramural fibroid showed a smooth muscle tumor arranged in intersecting fascicular pattern ( E , hematoxylin-eosin, ×100; F , hematoxylin-eosin, ×200). SSTR expression in uterine leiomyoma, although documented in few case reports, is a rare event 1–5 . It has been observed in animal studies that inflammation of the myometrium increases SSTR-2 and SSTR-5 expression 6 .…”

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confidence: 99%

“…SSTR expression in uterine leiomyoma, although documented in few case reports, is a rare event. [1][2][3][4][5] It has been observed in animal studies that inflammation of the myometrium increases SSTR-2 and SSTR-5 expression. 6 This case demonstrates very high SSTR expression; unlike previous cases reported in literature, this may occur in the presence of any ongoing degeneration.…”

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confidence: 99%

Incidentally Detected High SSTR Expression in Uterine Leiomyoma on DOTANOC PET/CT

Gupta

Kaushik

Ramteke³

et al. 2021

Clin Nucl Med

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A 38-year-old woman with a 2-month history of per vaginal bleeding and episodes of palpitations, headache, and vomiting underwent 68 Ga-DOTANOC PET/CT for evaluation, which revealed a left suprarenal mass and a large uterine mass, both of which were intensely tracer avid. Histopathology of the masses after surgery revealed a left pheochromocytoma and uterine leiomyoma. SSTR-expressing leiomyoma is an uncommon finding and must be kept in mind as a differential diagnosis of DOTANOC-avid uterine mass.

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An Incidentally Found Inflamed Uterine Myoma Causing Low Abdominal Pain, Using Tc-99m-Tektrotyd Single Photon Emission Computed Tomography-CT Hybrid Imaging

Cited by 7 publications

References 6 publications

Diagnostic and prognostic value of 99mTc-Tektrotyd scintigraphy and 18F-FDG PET/CT in a single-center cohort of neuroendocrine tumors

Diagnostic and prognostic value of 99mTc-Tektrotyd scintigraphy and 18F-FDG PET/CT in a single-center cohort of neuroendocrine tumors

99mTc-Octreotide Uptake in the Uterus and a Subserosal Myoma Mimicking Tumoral Masses

Incidentally Detected High SSTR Expression in Uterine Leiomyoma on DOTANOC PET/CT

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