99mTc-Octreotide Uptake in the Uterus and a Subserosal Myoma Mimicking Tumoral Masses

Abstract

The diagnostic usefulness of somatostatin receptor scintigraphy in the localization of tumors has been evaluated in several studies. Here, we present the case of a patient with a subserosal myoma diagnosed by 99m Tc-labeled octreotide acetate scintigraphy. Oval and ring-shaped areas of hyperactivity in the pelvis were confirmed on MR imaging to be the uterus and a subserosal myoma. The presented case indicates that somatostatin receptors may be present in the uterus and in leiomyomas, especially in young women, and demonstrates that somatostatin may be a promising therapy for treatment of myoma. The case also demonstrates that subserosal myoma or dislocation of the uterus can result in a false-positive diagnosis, highlighting the importance of correlative imaging for accurate interpretation of the study.

Production and Clinical Applications of Radiopharmaceuticals and Medical Radioisotopes in Iran

“…After surgical removal, the patient's symptoms resolved and significant clinical improvement was achieved. Pirayesh et al 25 reported a case of a neuroendocrine tumor in a 30-year-old woman in which 99m Tc-octreotide acetate scintigraphy revealed uptake in the uterus and a subserosal myoma mimicking tumoral masses. Tc-TRODAT-1 Production.…”

False-Positive 68Ga-DOTATATE Uptake in a Uterine Subserosal Fibroid Mimicking Mesenteric Neuroendocrine Tumor

“…According to Kagna et al, 11 the 68 Ga-DOTA-NOC uptake was not associated with any NET in 72% of cases, and the uterus was the third most common location of tracer accumulation. Furthermore, the benign uptake of DOTATATE tracer by uterine fibroid has been described in few studies, attributing to the aberrant expression of somatostatin receptors or hypermetabolism of the fibroid tissue 4,12,13 …”

“…Furthermore, the benign uptake of DOTATATE tracer by uterine fibroid has been described in few studies, attributing to the aberrant expression of somatostatin receptors or hypermetabolism of the fibroid tissue. 4,12,13…”

Incidentally Detected High SSTR Expression in Uterine Leiomyoma on DOTANOC PET/CT

“…SSTR expression in uterine leiomyoma, although documented in few case reports, is a rare event. [1][2][3][4][5] It has been observed in animal studies that inflammation of the myometrium increases SSTR-2 and SSTR-5 expression. 6 This case demonstrates very high SSTR expression; unlike previous cases reported in literature, this may occur in the presence of any ongoing degeneration.…”

“…Section examined ( E and F ) from the intramural fibroid showed a smooth muscle tumor arranged in intersecting fascicular pattern ( E , hematoxylin-eosin, ×100; F , hematoxylin-eosin, ×200). SSTR expression in uterine leiomyoma, although documented in few case reports, is a rare event 1–5 . It has been observed in animal studies that inflammation of the myometrium increases SSTR-2 and SSTR-5 expression 6 .…”