An in vivo study on the effect of coating stability on osteointegration performance of collagen/hyaluronic acid multilayer modified titanium implants

Abstract

Aseptic loosening of implant is one of the main causes of Ti-based implant failure. In our previous work, a novel stable collagen/hyaluronic acid (Col/HA) multilayer modified titanium coatings (TCs) was developed by layer-by-layer (LBL) covalent immobilization technique, which showed enhanced biological properties compared with TCs that were physically absorbed with Col/HA multilayer in vitro. In this study, a rabbit model with femur condyle defect was employed to compare the osteointegration performance of them. Results indicated that Col/HA multilayer with favourable stability could better facilitate osteogenesis around implants and bone-implant contact. The Col/HA multilayer covalent-immobilized TC may reduce aseptic loosening of implant.

The Recombinant Protein EphB4-Fc Changes the Ti Particle-Mediated Imbalance of OPG/RANKL via EphrinB2/EphB4 Signaling Pathway and Inhibits the Release of Proinflammatory Factors In Vivo

“…Aseptic loosening caused by osteolysis around the prosthesis remains one of the most common complications of joint replacement (Supplementary Figure S1) 11 Oxidative Medicine and Cellular Longevity researchers have not been able to prevent this complication through the structural design of the implant or through surface modification of the implant [33,34]. However, these methods are less likely to eliminate particle generation on the bearing surface.…”

The Recombinant Protein ephB4-Fc Changes the Ti-Particle Mediated Imbalance of OPG/RANKL Via ephrinB2/ephB4 Signaling Pathway and Inhibits the Release of Pro-Inflammatory Factors <i>in vivo</i>

“…Aseptic loosening caused by osteolysis around the prosthesis remains one of the most common complications of joint replacement (Supplementary Figure S1) [28,[30][31][32]. So far, 11 Oxidative Medicine and Cellular Longevity researchers have not been able to prevent this complication through the structural design of the implant or through surface modification of the implant [33,34]. However, these methods are less likely to eliminate particle generation on the bearing surface.…”

Review of the Applications of Biomedical Compositions Containing Hydroxyapatite and Collagen Modified by Bioactive Components

“…The stability of the implant prevents its aseptic loosening and supports osteogenesis around implants, reducing the risk of implant failure [249]. The effect of coating stability on osteointegration performance of coated metallic implants can be examined by numerous techniques, including micro X-ray computed tomography (micro-CT), scanning electron microscopy, and histological examinations by laser scanning confocal fluorescence microscopy [249,250]. However, in order to achieve reliable results of implant-stability investigation, it is also worth considering the use of friction and wear tests of coatings [251], examination of the shear strength of the bone implant interface in an in vivo model [252], and the strength of coating adhesion as well [253].…”

“…However, it is worth emphasizing that the success of a coated implant is largely dependent on its stability. The stability of the implant prevents its aseptic loosening and supports osteogenesis around implants, reducing the risk of implant failure [ 249 ]. The effect of coating stability on osteointegration performance of coated metallic implants can be examined by numerous techniques, including micro X-ray computed tomography (micro-CT), scanning electron microscopy, and histological examinations by laser scanning confocal fluorescence microscopy [ 249 , 250 ].…”